Modularity in support of design for re-use

We explore the structuring principle of modularity with the objective of analysing its current ability to meet the requirements of a 're-use' centred approach to design. We aim to highlight the correlation's between modular design and 're-use', and argue that it has the potential to aid the little-supported process of 'design-for-re-use'. In fulfilment of this objective we not only identify the requirements of 'design-for-re-use', but also propose how modular design principles can be extended to support 'design-for-re-use'

Re-using knowledge : why, what and where

Previously the 're-use' focus has centred on specific and/or standard parts, more recently however, [standard components] are being developed...to enable both the re-use of the part and the experience associated with that part'. This notion is further extended by Finger who states that 'designers may re-use a prior design in it's entirety,...may re-use an existing shape for a different function, or may re-use a feature from another design'. Reinforcing this notion we currently consider re-use to reflect the utilisation of any knowledge gained from a design activity and not just past designs of artefacts. Our research concerns the improvement of formal 're-use' support and as such we have identified a need to gain a better understanding of how design knowledge can be utilised to support 're-use'. Thus, we discuss the requirements of successful 're-use' and attempt to ascertain within this skeleton: what knowledge can be re-used; how to maximise its' applicability; and where and when it can be utilised in new design

Overdiagnosis in breast cancer screening: the importance of length of observation period and lead time

PMCID: PMC3706885This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Virtual integration platform for computational fluid dynamics

Computational Fluid Dynamics (CFD) tools used in shipbuilding industry involve multiple disciplines, such as resistance, manoeuvring, and cavitation. Traditionally, the analysis was performed separately and sequentially in each discipline, which often resulted in conflict and inconsistency of hydrodynamic prediction. In an effort to solve such problems for future CFD computations, a Virtual Integration Platform (VIP) has been developed in the University of Strathclyde within two EU FP6 projects - VIRTUE and SAFEDOR1. The VIP provides a holistic collaborative environment for designers with features such as Project/Process Management, Distributed Tools Integration, Global Optimisation, Version Management, and Knowledge Management. These features enhance collaboration among customers, ship design companies, shipyards, and consultancies not least because they bring together the best expertise and resources around the world. The platform has been tested in seven European ship design companies including consultancies. Its main functionalities along with advances are presented in this paper with two industrial applications

Complexities in the estimation of overdiagnosis in breast cancer screening

There is interest in estimating and attributing temporal changes in incidence of breast cancer in relation to the initiation of screening programmes, in particular to estimation of overdiagnosis of breast cancer as a result of screening. In this paper, we show how screening introduces complexities of analysis and interpretation of incidence data. For example, lead time brings forward time- and age-related increases in incidence. In addition, risk factors such as hormone replacement therapy use have been changing contemporaneously with the introduction of screening. Although we do not indicate exactly how such complexities should be corrected for, we use some simple informal adjustments to show how they may account for a substantial proportion of increased incidence, which might otherwise erroneously have been attributed to overdiagnosis. We illustrate this using an example of analysis of breast cancer incidence data from Sweden

Advection and Taylor-Aris dispersion in rivulet flow

Motivated by the need for a better understanding of the transport of solutes in microfluidic flows with free surfaces, the advection and dispersion of a passive solute in steady unidirectional flow of a thin uniform rivulet on an inclined planar substrate driven by gravity and/or a uniform longitudinal surface shear stress are analysed. Firstly, we describe the short-time advection of both an initially semi-infinite and an initially finite slug of solute of uniform concentration. Secondly, we describe the long-time Taylor-Aris dispersion of an initially finite slug of solute. In particular, we obtain the general expression for the effective diffusivity for Taylor-Aris dispersion in such a rivulet, and discuss in detail its different interpretations in the special case of a rivulet on a vertical substrate

Rivulet flow of generalized Newtonian fluids

Steady unidirectional gravity-driven flow of a uniform thin rivulet (i.e. a rivulet with small transverse aspect ratio) of a generalised Newtonian fluid down a vertical planar substrate is considered. The parametric solution for any generalised Newtonian fluid whose viscosity can be expressed as a function of the shear rate, and the explicit solution for any generalised Newtonian fluid whose viscosity can be expressed as a function of the extra stress are obtained. These general solutions are used to describe rivulet flow of Carreau and Ellis fluids, highlighting the similarities and differences between the behaviour of these two fluids. In addition, the general behaviour of rivulets of nearly Newtonian fluids and of rivulets with small or large prescribed flux, as well as the behaviour of rivulets of strongly shear-thinning Carreau and Ellis fluids, are also described. It is found that whereas the monotonic dependence of the viscosity of a Carreau fluid on its three non-dimensional parameters and of an Ellis fluid on two of its three non-dimensional parameters leads to the expected dependence of the behaviour of the rivulet on these parameters (namely that increasing the viscosity of the fluid leads to a larger rivulet), the non-monotonic dependence of the viscosity of an Ellis fluid on the non dimensional parameter that measures the degree of shear thinning leads to a more complicated dependence of the behaviour of the rivulet on this parameter. In particular, it is also found that when the maximum extra stress in the rivulet is sufficiently large a rivulet of an Ellis fluid in the strongly shear-thinning limit in which this parameter becomes large comprises two regions with different viscosities. In the general case of non-zero viscosity in the limit of large extra stress the two regions have different constant viscosities, whereas in the special case of zero viscosity in the limit of large extra stress one region has constant viscosity and the other has a non-constant power-law viscosity, leading to a plug-like velocity profile with large magnitude in the narrow central region of the rivulet

Modelling the overdiagnosis of breast cancer due to mammography screening in women aged 40 to 49 in the United Kingdom

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, andreproduction in any medium, provided the original work is properly cited