The design and use of a sparse direct solver for skew symmetric matrices

AbstractWe consider the LDLT factorization of sparse skew symmetric matrices. We see that the pivoting strategies are similar, but simpler, to those used in the factorization of sparse symmetric indefinite matrices, and we briefly describe the algorithms used in a forthcoming direct code based on multifrontal techniques for the factorization of real skew symmetric matrices. We show how this factorization can be very efficient for preconditioning matrices that have a large skew component

Incomplete Orthogonal Factorization Methods Using Givens Rotations II: Implementation and Results

We present, implement and test a series of incomplete orthogonal factorization methods based on Givens rotations for large sparse unsymmetric matrices. These methods include: column-Incomplete Givens Orthogonalization (cIGO-method), which drops entries by position only; column-Threshold Incomplete Givens Orthogonalization (cTIGO-method) which drops entries dynamically by both their magnitudes and positions and where the reduction via Givens rotations is done in a column-wise fashion; and, row-Threshold Incomplete Givens Orthogonalization (r-TIGO-method) which again drops entries dynamically, but only magnitude is now taken into account and reduction is performed in a row-wise fashion. We give comprehensive accounts of how one would code these algorithms using a high level language to ensure efficiency of computation and memory use. The methods are then applied to a variety of square systems and their performance as preconditioners is tested against standard incomplete LU factorization techniques. For rectangular matrices corresponding to least-squares problems, the resulting incomplete factorizations are applied as preconditioners for conjugate gradients for the system of normal equations. A comprehensive discussion about the uses, advantages and shortcomings of these preconditioners is given

Parallel computation of entries of A-1

In this paper, we are concerned about computing in parallel several entries of the inverse of a large sparse matrix. We assume that the matrix has already been factorized by a direct method and that the factors are distributed. Entries are efficiently computed by exploiting sparsity of the right-hand sides and the solution vectors in the triangular solution phase. We demonstrate that in this setting, parallelism and computational efficiency are two contrasting objectives. We develop an efficient approach and show its efficacy by runs using the MUMPS code that implements a parallel multifrontal method

Partitioning Strategies for the Block Cimmino algorithm (Precond 2011)

Session 9International audienc

Parallel computation of entries in A-1

International audienceIn this paper, we consider the computation in parallel of several entries of the inverseof a large sparse matrix. We assume that the matrix has already been factorized by a direct methodand that the factors are distributed. Entries are efficiently computed by exploiting sparsity of theright-hand sides and the solution vectors in the triangular solution phase. We demonstrate that inthis setting, parallelism and computational efficiency are two contrasting objectives. We develop anefficient approach and show its efficiency on a general purpose parallel multifrontal solver

The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity

Peer reviewedPublisher PD

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research