New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties

This study describes the preparation, characterization, and influence of the enantiopure vs. racemic coformer on the physico-chemical properties of a pharmaceutical cocrystal. For that purpose, two new 1:1 cocrystals, namely lidocaine:dl-menthol and lidocaine:d-menthol, were prepared. The menthol racemate-based cocrystal was evaluated by means of X-ray diffraction, infrared spectroscopy, Raman, thermal analysis, and solubility experiments. The results were exhaustively compared with the first menthol-based pharmaceutical cocrystal, i.e., lidocaine:l-menthol, discovered in our group 12 years ago. Furthermore, the stable lidocaine/dl-menthol phase diagram has been screened, thoroughly evaluated, and compared to the enantiopure phase diagram. Thus, it has been proven that the racemic vs. enantiopure coformer leads to increased solubility and improved dissolution of lidocaine due to the low stable form induced by menthol molecular disorder in the lidocaine:dl-menthol cocrystal. To date, the 1:1 lidocaine:dl-menthol cocrystal is the third menthol-based pharmaceutical cocrystal, after the 1:1 lidocaine:l-menthol and the 1:2 lopinavir:l-menthol cocrystals reported in 2010 and 2022, respectively. Overall, this study shows promising potential for designing new materials with both improved characteristics and functional properties in the fields of pharmaceutical sciences and crystal engineering

Quality of carbamazepine in resource-limited settings: Ancillary results from the QUAEDAF (Quality of AntiEpileptic Drugs in sub-Saharan Africa) study

Epilepsy is a common disorder affecting 70 million people worldwide, with 90% in resource-limited countries. in these countries,few standard antiepileptic drugs (AEDs) are used and concerned with quality issues. Often, the attention is focused on assay of active ingredient (AI). However, other pharmaceutical parameters are important, such as the dissolution profile that could be influenced by environmental factors. The main objective was to assess the stability of AEDs under stressed conditions

Quality of carbamazepine in resource-limited settings: Ancillary results from the QUAEDAF (Quality of AntiEpileptic Drugs in sub-Saharan Africa) study

Epilepsy is a common disorder affecting 70 million people worldwide, with 90% in resource-limited countries. in these countries,few standard antiepileptic drugs (AEDs) are used and concerned with quality issues. Often, the attention is focused on assay of active ingredient (AI). However, other pharmaceutical parameters are important, such as the dissolution profile that could be influenced by environmental factors. The main objective was to assess the stability of AEDs under stressed conditions