18 research outputs found
Kinematical Limits on Higgs Boson Production via Gluon Fusion in Association with Jets
In this paper, we analyze the high-energy limits for Higgs boson plus two jet
production. We consider two high-energy limits, corresponding to two different
kinematic regions: a) the Higgs boson is centrally located in rapidity between
the two jets, and very far from either jet; b) the Higgs boson is close to one
jet in rapidity, and both of these are very far from the other jet. In both
cases the amplitudes factorize into impact factors or coefficient functions
connected by gluons exchanged in the t channel. Accordingly, we compute the
coefficient function for the production of a Higgs boson from two off-shell
gluons, and the impact factors for the production of a Higgs boson in
association with a gluon or a quark jet. We include the full top quark mass
dependence and compare this with the result obtained in the large top-mass
limit.Comment: 35 pages, 6 figure
Color-flow decomposition of QCD amplitudes
We introduce a new color decomposition for multi-parton amplitudes in QCD,
free of fundamental-representation matrices and structure constants. This
decomposition has a physical interpretation in terms of the flow of color,
which makes it ideal for merging with shower Monte-Carlo programs. The
color-flow decomposition allows for very efficient evaluation of amplitudes
with many quarks and gluons, many times faster than the standard color
decomposition based on fundamental-representation matrices. This will increase
the speed of event generators for multi-jet processes, which are the principal
backgrounds to signals of new physics at colliders.Comment: 23 pages, 11 figures, version to appear on Phys. Rev.
BFKL versus O(\alpha_s^3) Corrections to Large-rapidity Dijet Production
We examine dijet production at large rapidity intervals at Tevatron energies
by comparing an exact calculation with the BFKL
approximation, which resums the leading powers of the rapidity interval to
all orders in . We analyze the dependence of the exact calculation on the jet cone-size as a function of , and use
this cross section to define an ``effective rapidity'' which reduces
the error that the large- approximation induces on the kinematics. Using
in the BFKL resummation, we reexamine jet production at large
transverse momenta and the transverse momentum decorrelation of the tagging
jets. We find less dramatic, but still significant, effects than found
previously using the large- approximation.Comment: 23 pages (6 uu-compressed encapsulated PS figures appended), DESY
94-114, SCIPP 94/1
Multiple Singular Emission in Gauge Theories
I derive a class of functions unifying all singular limits for the emission
of a given number of soft or collinear gluons in tree-level gauge-theory
amplitudes. Each function is a generalization of the single-emission antenna
function of ref. [1]. The helicity-summed squares of these functions are thus
also generalizations to multiple singular emission of the Catani--Seymour
dipole factorization function.Comment: Corrections for final journal version (sign in eqn. (6.11), equation
references, typos in indices) & removal of comment about FD
Two-Loop Helicity Amplitudes for Quark-Gluon Scattering in QCD and Gluino-Gluon Scattering in Supersymmetric Yang-Mills Theory
We present the two-loop QCD helicity amplitudes for quark-gluon scattering,
and for quark-antiquark annihilation into two gluons. These amplitudes are
relevant for next-to-next-to-leading order corrections to (polarized) jet
production at hadron colliders. We give the results in the `t Hooft-Veltman and
four-dimensional helicity (FDH) variants of dimensional regularization. The
transition rules for converting the amplitudes between the different variants
are much more intricate than for the previously discussed case of gluon-gluon
scattering. Summing our two-loop expressions over helicities and colors, and
converting to conventional dimensional regularization, gives results in
complete agreement with those of Anastasiou, Glover, Oleari and Tejeda-Yeomans.
We describe the amplitudes for 2 to 2 scattering in pure N=1 supersymmetric
Yang-Mills theory, obtained from the QCD amplitudes by modifying the color
representation and multiplicities, and verify supersymmetry Ward identities in
the FDH scheme.Comment: 77 pages. v2: corrected errors in eqs. (3.7) and (3.8) for one-loop
assembly; remaining results unaffecte
Supersymmetric Regularization, Two-Loop QCD Amplitudes and Coupling Shifts
We present a definition of the four-dimensional helicity (FDH) regularization
scheme valid for two or more loops. This scheme was previously defined and
utilized at one loop. It amounts to a variation on the standard 't
Hooft-Veltman scheme and is designed to be compatible with the use of helicity
states for "observed" particles. It is similar to dimensional reduction in that
it maintains an equal number of bosonic and fermionic states, as required for
preserving supersymmetry. Supersymmetry Ward identities relate different
helicity amplitudes in supersymmetric theories. As a check that the FDH scheme
preserves supersymmetry, at least through two loops, we explicitly verify a
number of these identities for gluon-gluon scattering (gg to gg) in
supersymmetric QCD. These results also cross-check recent non-trivial two-loop
calculations in ordinary QCD. Finally, we compute the two-loop shift between
the FDH coupling and the standard MS-bar coupling, alpha_s. The FDH shift is
identical to the one for dimensional reduction. The two-loop coupling shifts
are then used to obtain the three-loop QCD beta function in the FDH and
dimensional reduction schemes.Comment: 44 pages, minor corrections and clarifications include
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Exposure to chlorinated drinking water alters the murine fecal microbiota
An abundant body of scientific studies and regulatory guidelines substantiates antimicrobial efficacy of freshwater chlorination ensuring drinking water safety in large populations worldwide. In contrast to the purposeful use of chlorination ensuring antimicrobial safety of drinking water, only a limited body of research has addressed the molecular impact of chlorinated drinking water exposure on the gut microbiota. Here, for the first time, we have examined the differential effects of drinking water regimens stratified by chlorination agent [inorganic (HOCl) versus chloramine (TCIC)] on the C57BL/6J murine fecal microbiota. To this end, we exposed C57BL/6J mice to chlorinated drinking water regimens followed by fecal bacterial microbiota analysis at the end of the three-week feeding period employing 16S rRNA sequencing. α-diversity was strongly reduced when comparing chlorinated versus control drinking water groups and community dissimilarities (β-diversity) were significant between groups even when comparing HOCl and TCIC. We detected significant differences in fecal bacterial composition as a function of drinking water chlorination observable at the phylum and genus levels. Differential abundance analysis of select amplicon sequence variants (ASVs) revealed changes as a function of chlorination exposure [up: Lactobacillus ASV1; Akkermansia muciniphila ASV7; Clostridium ss1 ASV10; down: Ileibacterium valens ASV5; Desulfovibrio ASV11; Lachnospiraceae UCG-006 ASV15]. Given the established complexity of murine and human gastrointestinal microbiota and their role in health and disease, the translational relevance of the chlorination-induced changes documented by us for the first time in the fecal murine microbiota remains to be explored. © 2024 The AuthorsOpen access articleThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
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Longitudinal Characterization of the Gut Microbiota in the Diabetic ZDSD Rat Model and Therapeutic Potential of Oligofructose
The complex development of type 2 diabetes (T2D) creates challenges for studying the progression and treatment of the disease in animal models. A newly developed rat model of diabetes, the Zucker Diabetic Sprague Dawley (ZDSD) rat, closely parallels the progression of T2D in humans. Here, we examine the progression of T2D and associated changes in the gut microbiota in male ZDSD rats and test whether the model can be used to examine the efficacy of potential therapeutics such as prebiotics, specifically oligofructose, that target the gut microbiota. Bodyweight, adiposity, and fed/fasting blood glucose and insulin were recorded over the course of the study. Glucose and insulin tolerance tests were performed, and feces collected at 8, 16, and 24 weeks of age for short-chain fatty acids and microbiota analysis using 16s rRNA gene sequencing. At the end of 24 weeks of age, half of the rats were supplemented with 10% oligofructose and tests were repeated. We observed a transition from healthy/nondiabetic to prediabetic and overtly diabetic states, via worsened insulin and glucose tolerance and significant increases in fed/fasted glucose, followed by a significant decrease in circulating insulin. Acetate and propionate levels were significantly increased in the overt diabetic state compared to healthy and prediabetic. Microbiota analysis demonstrated alterations in the gut microbiota with shifts in alpha and beta diversity as well as alterations in specific bacterial genera in healthy compared to prediabetic and diabetic states. Oligofructose treatment improved glucose tolerance and shifted the cecal microbiota of the ZDSD rats during late-stage diabetes. These findings underscore the translational potential of ZDSD rats as a model of T2D and highlight potential gut bacteria that could impact the development of the disease or serve as a biomarker for T2D. Additionally, oligofructose treatment was able to moderately improve glucose homeostasis. © 2023 by the authors.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
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A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity
Hepatic lipid accumulation is a hallmark of type II diabetes (T2D) associated with hyperinsulinemia, insulin resistance, and hyperphagia. Hepatic synthesis of GABA, catalyzed by GABA-transaminase (GABA-T), is upregulated in obese mice. To assess the role of hepatic GABA production in obesity-induced metabolic and energy dysregulation, we treated mice with two pharmacologic GABA-T inhibitors and knocked down hepatic GABA-T expression using an antisense oligonucleotide. Hepatic GABA-T inhibition and knockdown decreased basal hyperinsulinemia and hyperglycemia and improved glucose intolerance. GABA-T knockdown improved insulin sensitivity assessed by hyperinsulinemic-euglycemic clamps in obese mice. Hepatic GABA-T knockdown also decreased food intake and induced weight loss without altering energy expenditure in obese mice. Data from people with obesity support the notion that hepatic GABA production and transport are associated with serum insulin, homeostatic model assessment for insulin resistance (HOMA-IR), T2D, and BMI. These results support a key role for hepatocyte GABA production in the dysfunctional glucoregulation and feeding behavior associated with obesity. © 2021Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]