2 research outputs found
Dynamics and Control of Oscillatory Bioreactors
Bioreactors are widely used in many industries to generate a range of
products using various host cells e.g., yeast, insect, and mammalian cells.
Depending on the process, product, and host cell, some bioreactors exhibit
sustained periodic behavior in key process variables such as metabolite
concentrations, biomass, and product titer. Such dynamical behavior can arise
from different mechanisms, including predator-prey dynamics, substrate
inhibition, and cell sub-population synchrony. Oscillatory dynamical behavior
is undesirable as it can impact downstream processes, especially in a
continuous operation, and can make process operations and product quality
control more challenging. This article provides an overview of oscillatory
dynamics. The mechanisms that give rise to the oscillations and process control
strategies for suppressing the oscillations are discussed, while providing
insights that go beyond past studies. Alternative process configurations are
proposed for bypassing the mechanisms that generate oscillations.Comment: Submitted to Biotechnology Progress, ICB V Special Issue (invited).
Pavan Inguva and Krystian Ganko contributed equally to this work.
Corresponding author: Richard D. Braat
Biomanufacturing and testbed development for the continuous production of monoclonal antibodies
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