Accuracy of elastic fusion biopsy in daily practice: results of a multicenter study of 2115 patients

OBJECTIVES: To assess the accuracy of Koelis fusion biopsy for the detection of prostate cancer and clinically significant prostate cancer in the everyday practice. METHODS: We retrospectively enrolled 2115 patients from 15 institutions in four European countries undergoing transrectal Koelis fusion biopsy from 2010 to 2017. A variable number of target (usually 2-4) and random cores (usually 10-14) were carried out, depending on the clinical case and institution habits. The overall and clinically significant prostate cancer detection rates were assessed, evaluating the diagnostic role of additional random biopsies. The cancer detection rate was correlated to multiparametric magnetic resonance imaging features and clinical variables. RESULTS: The mean number of targeted and random cores taken were 3.9 (standard deviation 2.1) and 10.5 (standard deviation 5.0), respectively. The cancer detection rate of Koelis biopsies was 58% for all cancers and 43% for clinically significant prostate cancer. The performance of additional, random cores improved the cancer detection rate of 13% for all cancers (P < 0.001) and 9% for clinically significant prostate cancer (P < 0.001). Prostate cancer was detected in 31%, 66% and 89% of patients with lesions scored as Prostate Imaging Reporting and Data System 3, 4 and 5, respectively. Clinical stage and Prostate Imaging Reporting and Data System score were predictors of prostate cancer detection in multivariate analyses. Prostate-specific antigen was associated with prostate cancer detection only for clinically significant prostate cancer. CONCLUSIONS: Koelis fusion biopsy offers a good cancer detection rate, which is increased in patients with a high Prostate Imaging Reporting and Data System score and clinical stage. The performance of additional, random cores seems unavoidable for correct sampling. In our experience, the Prostate Imaging Reporting and Data System score and clinical stage are predictors of prostate cancer and clinically significant prostate cancer detection; prostate-specific antigen is associated only with clinically significant prostate cancer detection, and a higher number of biopsy cores are not associated with a higher cancer detection rate

Exposé des résultats obtenus à Marolles, Commune de Genillé (Indre-et-Loire), sur des défrichements de landes et de bruyères, par l'emploi du noir animal à petite dose et mêlé à la semence : notice sur l'exploitation de Marolles

par M. Dubreuil-Chambardel ;Exlibrisstempel: "A.V. Système d'Echange International" 011056737_0001 Exemplar der ETH-BI

Les objectifs de la recherche sur les accidents graves

Les accidents graves de réacteurs ou accidents de fusion du coeur sont caractérisés par l’importance des rejets radioactifs qu’ils peuvent générer. En conséquence, un ensemble de mesures de prévention comme de limitation des conséquences ont été prises en France comme à l’étranger d’abord historiquement à l’issue de l’accident de Three Mile Island, puis selon une démarche d’identification des risques associés aux différents phénomènes, plus récemment, enfin, en s’appuyant sur des considérations probabilistes. La recherche et le développement sous-tendent largement cette évolution en fournissant les connaissances, méthodes et outils. Différentes contraintes s’appliquent à la recherche notamment les coûts élevés associés qui justifient une internationalisation et une hiérarchisation