How will disenfranchised Peoples adapt to Climate Change? Strengthening the Ecojustice Movement

The Fourth assessment of the Intergovernmental Panel on Climate Change (IPCC) acknowledged That millions of people are currently, and will increasingly be, affected by the impacts of climate change, in the form of floods, droughts and other extreme events, as well as related threats to food security. In response to these global environmental changes, the international community, including civil society, is acting on the need for immediate adaptation measures and is developing strategies for future adaptation. However, the impacts of climate change are unevenly distributed, with many of the poorest, most vulnerable peoples experiencing the immediate effects of climate change, in the here and now. As the IPCC noted, developing countries are disproportionately affected by climate change and often, the least able to adapt due to lack of infrastructure and resources

Indicadores para a avaliação da disponibilidade hídrica para o desenvolvimento sustentável da atividade canavieira irrigada.

Para a racionalização do uso dos recursos hídricos e promoção do desenvolvimento sustentável da atividade canavieira na região Centro-Oeste torna-se importante o desenvolvimento de procedimentos metodológicos que possam fornecer subsídios técnicos para o planejamento e gestão setorial - agricultura e recursos hídricos. O presente trabalho apresenta dois indicadores concebidos para a avaliação do potencial da disponibilidade hídrica para atender a demanda projetada de água para o desenvolvimento da atividade canavieira

Sistema de indicadores para a avaliação da sustentabilidade hídrica da atividade canaviera.

O objetivo deste trabalho é apresentar um estudo de caso realizado na Bacia Hidrográfica do Rio Verde (BHRV) para demonstrar a aplicabilidade do Sistema de Indicadores - SISHidro-Cana - para a avaliação da sustentabilidade hídrica da cultura canavieira, proposta por Ferraz (2012), como uma metodologia para avaliar a disponibilidade de água de bacias hidrográficas para subsidiar a proposição de políticas setoriais, ordenação territorial, planejamento agrícola e gestão dos recursos hídricos

Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway

Prevailing models place spectrin downstream of ankyrin in a pathway of assembly and function in polarized cells. We used a transgene rescue strategy in Drosophila melanogaster to test contributions of four specific functional sites in β spectrin to its assembly and function. (1) Removal of the pleckstrin homology domain blocked polarized spectrin assembly in midgut epithelial cells and was usually lethal. (2) A point mutation in the tetramer formation site, modeled after a hereditary elliptocytosis mutation in human erythrocyte spectrin, had no detectable effect on function. (3) Replacement of repetitive segments 4–11 of β spectrin with repeats 2–9 of α spectrin abolished function but did not prevent polarized assembly. (4) Removal of the putative ankyrin-binding site had an unexpectedly mild phenotype with no detectable effect on spectrin targeting to the plasma membrane. The results suggest an alternate pathway in which spectrin directs ankyrin assembly and in which some important functions of spectrin are independent of ankyrin

The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton

<p>Abstract</p> <p>Background</p> <p>Current models suggest that the spectrin cytoskeleton stabilizes interacting ion transport proteins at the plasma membrane. The human erythrocyte anion exchanger (AE1) was the first membrane transport protein found to be associated with the spectrin cytoskeleton. Here we evaluated a conserved anion exchanger from Drosophila (DAE) as a marker for studies of the downstream effects of spectrin cytoskeleton mutations.</p> <p>Results</p> <p>Sequence comparisons established that DAE belongs to the SLC4A1-3 subfamily of anion exchangers that includes human AE1. Striking sequence conservation was observed in the C-terminal membrane transport domain and parts of the N-terminal cytoplasmic domain, but not in the proposed ankyrin-binding site. Using an antibody raised against DAE and a recombinant transgene expressed in <it>Drosophila </it>S2 cells DAE was shown to be a 136 kd plasma membrane protein. A major site of expression was found in the stomach acid-secreting region of the larval midgut. DAE codistributed with an infolded subcompartment of the basal plasma membrane of interstitial cells. However, spectrin did not codistribute with DAE at this site or in anterior midgut cells that abundantly expressed both spectrin and DAE. Ubiquitous knockdown of DAE with dsRNA eliminated antibody staining and was lethal, indicating that DAE is an essential gene product in <it>Drosophila</it>.</p> <p>Conclusions</p> <p>Based on the lack of colocalization and the lack of sequence conservation at the ankyrin-binding site, it appears that the well-characterized interaction between AE1 and the spectrin cytoskeleton in erythrocytes is not conserved in <it>Drosophila</it>. The results establish a pattern in which most of the known interactions between the spectrin cytoskeleton and the plasma membrane in mammals do not appear to be conserved in <it>Drosophila</it>.</p