Učestalost metaboličkog sindroma u bolesnika s psorijazom u Kliničkoj bolnici Mostar

Psoriasis is a chronic inflammatory skin disease. Metabolic syndrome is composed of obesity, hyperglycemia, hypertension and dyslipidemia. Previous reports have shown higher prevalence of metabolic syndrome in patients with psoriasis. It is believed that similar inflammatory changes lie in the pathophysiological background of psoriasis and metabolic syndrome. The main objective of this study was to assess the prevalence of metabolic syndrome and its components in patients with psoriasis, as well as to investigate the presence of systemic signs of inflammation such as erythrocyte sedimentation rate and C-reactive protein. The study included 60 patients with psoriasis and the same number of control subjects. We measured anthropometric and laboratory parameters; metabolic syndrome was defined according to the National Cholesterol Education Program-Adult Treatment Panel III criteria and Psoriasis Area and Severity Index was determined in all patients with psoriasis. This study showed a statistically significant presence of obesity (48.3%) and hyperglycemia (23.3%) in patients with psoriasis, while the prevalence of metabolic syndrome was 46.7%. These findings should encourage practitioners to screen psoriasis patients, especially when the disease is severe, for metabolic disorders and introduce appropriate prevention strategies.Psorijaza je kronična upalna kožna bolest. Metabolički sindrom se sastoji od pretilosti, hiperglikemije, hipertenzije i dislipidemije. U prethodnim istraživanjima uočena je povećana učestalost metaboličkog sindroma u bolesnika s psorijazom. Smatra se da su u patofiziološkoj podlozi psorijaze i metaboličkog sindroma slične upalne promjene. Glavni cilj istraživanja je bio utvrditi učestalost metaboličkog sindroma i njegovih sastavnica u oboljelih od psorijaze, kao i ispitati prisutnost sistemskih znakova upale, sedimentacije i C-reaktivnog proteina. Istraživanje je uključilo 60 bolesnika s psorijazom i jednak broj bolesnika ispitne skupine. Određeni su antropometrijski i laboratorijski parametri, dijagnoza metaboličkog sindroma je postavljena na osnovi kriterija koje je definirao NCEP-ATP III (National Cholesterol Education Program-Adult Treatment Panel III), a PASI indeks (Psoriasis Area and Severity Index) je određen svim bolesnicima s psorijazom. Istraživanje je pokazalo statistički značajno učestaliju pretilost (48,3%) i hiperglikemiju (23,3%) u skupini bolesnika s psorijazom, a učestalost metaboličkog sindroma iznosila je 46,7%. Ovi rezultati trebali bi liječnike potaknuti na probir bolesnika s psorijazom, naročito onih s teškim oblikom bolesti, na metaboličke poremećaje i uvođenje odgovarajuće prevencije

Učestalost metaboličkog sindroma u bolesnika s psorijazom u Kliničkoj bolnici Mostar

Psoriasis is a chronic inflammatory skin disease. Metabolic syndrome is composed of obesity, hyperglycemia, hypertension and dyslipidemia. Previous reports have shown higher prevalence of metabolic syndrome in patients with psoriasis. It is believed that similar inflammatory changes lie in the pathophysiological background of psoriasis and metabolic syndrome. The main objective of this study was to assess the prevalence of metabolic syndrome and its components in patients with psoriasis, as well as to investigate the presence of systemic signs of inflammation such as erythrocyte sedimentation rate and C-reactive protein. The study included 60 patients with psoriasis and the same number of control subjects. We measured anthropometric and laboratory parameters; metabolic syndrome was defined according to the National Cholesterol Education Program-Adult Treatment Panel III criteria and Psoriasis Area and Severity Index was determined in all patients with psoriasis. This study showed a statistically significant presence of obesity (48.3%) and hyperglycemia (23.3%) in patients with psoriasis, while the prevalence of metabolic syndrome was 46.7%. These findings should encourage practitioners to screen psoriasis patients, especially when the disease is severe, for metabolic disorders and introduce appropriate prevention strategies.Psorijaza je kronična upalna kožna bolest. Metabolički sindrom se sastoji od pretilosti, hiperglikemije, hipertenzije i dislipidemije. U prethodnim istraživanjima uočena je povećana učestalost metaboličkog sindroma u bolesnika s psorijazom. Smatra se da su u patofiziološkoj podlozi psorijaze i metaboličkog sindroma slične upalne promjene. Glavni cilj istraživanja je bio utvrditi učestalost metaboličkog sindroma i njegovih sastavnica u oboljelih od psorijaze, kao i ispitati prisutnost sistemskih znakova upale, sedimentacije i C-reaktivnog proteina. Istraživanje je uključilo 60 bolesnika s psorijazom i jednak broj bolesnika ispitne skupine. Određeni su antropometrijski i laboratorijski parametri, dijagnoza metaboličkog sindroma je postavljena na osnovi kriterija koje je definirao NCEP-ATP III (National Cholesterol Education Program-Adult Treatment Panel III), a PASI indeks (Psoriasis Area and Severity Index) je određen svim bolesnicima s psorijazom. Istraživanje je pokazalo statistički značajno učestaliju pretilost (48,3%) i hiperglikemiju (23,3%) u skupini bolesnika s psorijazom, a učestalost metaboličkog sindroma iznosila je 46,7%. Ovi rezultati trebali bi liječnike potaknuti na probir bolesnika s psorijazom, naročito onih s teškim oblikom bolesti, na metaboličke poremećaje i uvođenje odgovarajuće prevencije

Most Common Skin Tumours in Correlation with Solar Ultraviolet Radiation in the Area of West Herzegovina

Incidence rate of skin tumours, both, non-melanoma and melanoma, is increasing nowadays. Various etiological factors are of relevance for the occurrence of the diseases. The solar radiation, as well, long term exposure to ultraviolet (UV) radiation, have the greatest impact on development of these skin tumours. Non-melanoma skin tumours, Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC), are the most common skin tumours in humans, and usually develop on the chronically photo-exposed areas. As for the Malignant Melanoma (MM), one of the most aggressive skin tumours, the exposure to solar radiation also plays an important role. This study investigates the correlation between the skin tumours and UV radiation in the area of West Herzegovina, on the sample of 1676 patients. It presents the occurrence of skin tumours in the period from 1997 to 2003. The study investigates the incidence and the risk factors separately for every skin tumour which can be etiologically related to the occurrence of skin tumours and UV radiation: occupation, exposure to UV radiation, skin type, and family history on malignan tumours within the patient’s family. The exact incidence rate of non-melanoma and melanoma skin tumours in Bosnia and Herzegovina is still unknown, for the reason that the united National Cancer Register does not exist yet

Most Common Skin Tumours in Correlation with Solar Ultraviolet Radiation in the Area of West Herzegovina

Incidence rate of skin tumours, both, non-melanoma and melanoma, is increasing nowadays. Various etiological factors are of relevance for the occurrence of the diseases. The solar radiation, as well, long term exposure to ultraviolet (UV) radiation, have the greatest impact on development of these skin tumours. Non-melanoma skin tumours, Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC), are the most common skin tumours in humans, and usually develop on the chronically photo-exposed areas. As for the Malignant Melanoma (MM), one of the most aggressive skin tumours, the exposure to solar radiation also plays an important role. This study investigates the correlation between the skin tumours and UV radiation in the area of West Herzegovina, on the sample of 1676 patients. It presents the occurrence of skin tumours in the period from 1997 to 2003. The study investigates the incidence and the risk factors separately for every skin tumour which can be etiologically related to the occurrence of skin tumours and UV radiation: occupation, exposure to UV radiation, skin type, and family history on malignan tumours within the patient’s family. The exact incidence rate of non-melanoma and melanoma skin tumours in Bosnia and Herzegovina is still unknown, for the reason that the united National Cancer Register does not exist yet

Risk Factors Associated with the Occurrence of Basal Cell Carcinoma

Basal cell carcinoma (BCC) is the most frequent malignant skin tumor, which is associated with both genetic factors and environmental influences. The objective of this study was to investigate the risk factors associated with the occurrence of BCC in the inhabitants of the Western Herzegovina area. The study took place during 1997 – 2003. We examined the risk factors which are presumably associated with the occurrence of BCC: skin type, exposure to UV rays and family occurrence of BCC, supplemented by the examination of the skin type, UV rays and existence of malignant tumors amongst the family members. We recorded a high correlation between the type of skin and the risk of occurrence of BCC. Long term and frequent skin exposure to UV rays were also associated with BCC. We also recorded increased risk for BCC in persons whose family members suffered from malignant skin tumors. Avoiding exposure to the sun as well as protection from UV rays may decrease the risk of BCC

Risk Factors Associated with the Occurrence of Basal Cell Carcinoma

Basal cell carcinoma (BCC) is the most frequent malignant skin tumor, which is associated with both genetic factors and environmental influences. The objective of this study was to investigate the risk factors associated with the occurrence of BCC in the inhabitants of the Western Herzegovina area. The study took place during 1997 – 2003. We examined the risk factors which are presumably associated with the occurrence of BCC: skin type, exposure to UV rays and family occurrence of BCC, supplemented by the examination of the skin type, UV rays and existence of malignant tumors amongst the family members. We recorded a high correlation between the type of skin and the risk of occurrence of BCC. Long term and frequent skin exposure to UV rays were also associated with BCC. We also recorded increased risk for BCC in persons whose family members suffered from malignant skin tumors. Avoiding exposure to the sun as well as protection from UV rays may decrease the risk of BCC

Cutis Verticis Gyrata – A Case Report

Cutis verticis gyrata (CVG) is a skin condition characterized by excessive growth of the skin of the scalp, resulting in furrows and folds which are similar to the gyri of the brain cortex. CVG can be classified into two forms: primary (essential and non-essential) and secondary. We report the case of a 53-year-old male patient with the primary type of CVG. The patient did not present with any cutaneous complication. His main complaint was the unaesthetic aspect of his scalp related to a psychological inferiority complex.</p

PSYCHOLOGICAL STATUS AND QUALITY OF LIFE IN ACNE PATIENTS TREATED WITH ORAL ISOTRETINOIN

Introduction: The acne patients are at higher risk of acquiring depresion and anxiety, which can lead to reduced quality of life. Effective treatment of acne can reduce symptoms of anxiety and depression and significantly improve other physiological parameters and quality of life of these patients. The aim of this study was to determine the psychological status and quality of life of acne patients before, during and after the treatment with oral isotretinoin. Subjects and methods: The prospective study included a total of 127 patients suffering from moderate to severe form of acne. To assess the psychological status and quality of life of studied groups the following standard psychometric questionnaires were performed before, during and after the treatment with oral isotretinoin: Beck Depression Inventory (BDI), Assessments of the Psychological and Social Effects of Acne (APSEA), State Trait Anxiety Inventory (STAI), Measure of Psychological Stress (MPS) and Dermatology Specific Quality of Life (DSQL). Results: Results of the present study indicate that there is no increase in depressive and anxiety symptoms in the patients treated with oral isotretinoin. The psychological status by gender has shown the existence of differences between the genders in all measures of psychological status. Statistically significantly better quality of life was observed after healing than before treatment. Conclusion: The results of our study showed no higher risk of depression and anxiety within the patients with acne treated with oral isotretinoin. Improvement of quality of life after the treatment of acne with oral isotretinoin was confirmed

The Mechanisms of UV Radiation in the Development of Malignant Melanoma

The sunlight was one of the first agents recognized to be carcinogenic for humans. There is convincing evidence from epidemiologic studies that exposure to solar radiation is the major cause of cutaneous melanoma in light-pigmented populations and plays a role in the increasing incidence of this malignancy. The molecular mechanisms by which UV radiation exerts its varied effects are not completely understood, however, it is considered that UVA and UVB are equally critical players in melanoma formation. Whereas UVA can indirectly damage DNA through the formation of reactive oxygen radicals, UVB can directly damage DNA causing the apoptosis of keratinocytes by forming the sunburn cells. Besides action through mutations in critical regulatory genes, UV radiation may promote cancer through indirect mechanisms, e.g. immunosuppression and dysregulation of growth factors. The carcinogenic process probably involves multiple sequential steps, some, but not all of which involve alterations in DNA structure

ANALYSIS OF PSYCHOPATHOLOGICAL TRAITS IN PSORIATIC PATIENTS

Psoriasis vulgaris is a multifactorial, heterogeneous disease that is associated with problems in skin image and feelings of shame and stigmatization. The aim of this study was to analyze psychopathological traits in patients with psoriasis and a comparative group. A total of 254 dermatological patients participated in the study: 124 patients with confirmed diagnoses of psoriasis vulgaris and 130 patients with melanocytic and non-melanocytic nevi on covered parts of the body. Psychometrically mensural and standardized instruments were used in the study: list of general data, appendix of disease data, Beck Depression Inventory test, State-Trait Anxiety Inventory, Measure of psychological stress and Eysenck’s Personal Questionnaire. There is a significant statistical difference in the result of psychometric tests between the study groups. Patients with psoriasis have more severe symptoms of depression, more physical symptoms of anxiety and higher results on the anxiety scale as a state and as a trait p=0.000. Eysenck\u27s personal questionnaire showed higher results on the psychoticism scale p=0.000 and lower results on the extraversion scale p=0.035 among psoriatic patients