Acute promyelocytic leukemia after whole brain irradiation of primary brain lymphomainan HIV-infected patient

The occurrence of acute promyelocytic leukemia (APL) in HIV-infected patients has been reported in only five cases. Due to a very small number of reported HIV/APL patients who have been treated with different therapies with the variable outcome, the prognosis of APL in the setting of the HIV-infection is unclear. Here, we report a case of an HIV-patient who developed APL and upon treatment entered a complete remission. A 25-years old male patient was diagnosed with HIV-infection in 1996, but remained untreated. In 2004, the patient was diagnosed with primary central nervous system lymphoma. We treated the patient with antiretroviral therapy and whole-brain irradiation, resulting in complete remission of the lymphoma. In 2006, prompted by a sudden neutropenia, we carried out a set of diagnostic procedures, revealing APL. Induction therapy consisted of standard treatment with all-trans-retinoic-acid (ATRA) and idarubicin. Subsequent cytological and molecular analysis of bone marrow demonstrated complete hematological and molecular remission. Due to the poor general condition, consolidation treatment with ATRA was given in March and April 2007. The last follow-up 14 months later, showed sustained molecular APL remission. In conclusion, we demonstrated that a complete molecular APL remission in an HIV-patient was achieved by using reduced-intensity treatment

The Effect of a Paired Lab on Course Completion and Grades in Nonmajors Introductory Biology

This paper explores the effect of a paired lab course on students’ course outcomes in nonmajors introductory biology at the University of Alaska Anchorage. We compare course completion and final grades for 10,793 students (3736 who simultaneously enrolled in the lab and 7057 who did not). Unconditionally, students who self-select into the lab are more likely to complete the course and to earn a higher grade than students who do not. However, when we condition on observable course, academic, and demographic characteristics, we find much of this difference in student performance outcomes is attributable to selection bias, rather than an effect of the lab itself. The data and discussion challenge the misconception that labs serve as recitations for lecture content, noting that the learning objectives of science labs should be more clearly articulated and assessed independent of lecture course outcomes. This paper explores the effect of a paired lab course on students’ course outcomes in introductory biology for nonmajors at the University of Alaska Anchorage (UAA), a large, open-enrollment, 4-year university. We compare outcomes for 10,793 students, 3736 who simultaneously enrolled in the lab and 7057 who did not, and analyze the degree to which they select into the lab on observable characteristics to explore the following research questions: 1. Are students who take a paired lab more likely to complete the lecture component (i.e., receive a final grade as opposed to withdrawing or receiving an Incomplete)? 2. Are students who take a paired lab more likely to receive a higher grade in the lecture component? 3. Does the laboratory experience differently affect course outcomes for students in specific demographic subgroups (e.g., gender, race, high school urbanicity, age, prior academic performance, and socioeconomic status)

The incidence of injuries in elite junior figure skaters

The incidence of injuries in elite junior figure skaters. Dubravcic-Simunjak S, Pecina M, Kuipers H, Moran J, Haspl M. Department of Physical Medicine and Rehabilitation, Sveti Duh General Hospital, Zagreb, Croatia. BACKGROUND: There has been rapid growth in the technical and physiologic demands made on skaters who perform more and more difficult jumps, spins, lifts, throws, and free skating movements. PURPOSE: To investigate the frequency of injuries and overuse syndromes in elite junior skaters. STUDY DESIGN: Questionnaire. METHODS: During four consecutive Junior World Figure Skating Championships and the Croatia Cup, we interviewed 236 female and 233 male skaters by questionnaire to determine the frequency of injuries and overuse syndromes. RESULTS: Fifty-nine of the female skaters (25%) and 65 of the male skaters (27.9%) reported sustaining acute injuries; 101 female (42.8%) and 106 male (45.5%) skaters reported overuse syndromes. Low back pain was reported by 19 female and 23 male skaters. The most frequent acute injury was ankle sprain. In singles female skaters, the most frequent overuse injury was stress fracture (19.8%), followed by jumper's knee (14.9%). In singles male skaters, jumper's knee (16.1%) was the most frequent injury, followed by Osgood-Schlatter disease (14.2%). More than 50% of injuries in young singles figure skaters involved overuse syndromes. Pairs skaters and ice dance skaters had a higher risk of acute injury than overuse syndrome because of falls from lifts and throw jumps. CONCLUSIONS: Programs to improve postural alignment, flexibility, and strength, especially during the asynchronous period of bone and soft tissue development, should be instituted to prevent and reduce overuse syndrome

Stress fracture prevalence in elite figure skaters

Figure skating is a physically demanding sport that requires a unique combination of artistic ability, speed, agility, flexibility and power. During the last decades not only the competitive schedule has become tougher, but after introduction of the new judging system in 2003, also more emphasis is put on difficult technical elements, jumps, steps and spins (ISU Rules, 2006). More studies about possible increasing prevalence of stress fractures in figure skaters and contributing factors are lacking (Dubravcic-Simunjak et al., 2003; Moran, 2000; Pecina et al., 1990). Therefore the aim of this study was to obtain data about the current stress fracture cumulative risk among elite junior and senior figure skaters, as well as possible factors that may contribute to stress fracture incidence. An anonymous questionnaire, divided into 5 sections, inquired about the prevalence of stress fracture were mailed and distributed to all 62 International Skating Union (ISU) members by the ISU headquarters in Lausanne, Switzerland. The guidelines of the Helsinki declaration 2004 were followed. From the 644 skaters who received the questionnaire, 412 completed ones were returned from 110 female juniors (78 single skaters, 12 pair skaters and 20 ice dancers) and 135 female seniors (97 single skaters, 16 pair skaters and 22 ice dancers) and from 79 male juniors (47 single skaters, 12 pair skaters and 20 ice dancers) and 88 male seniors (50 single skaters, 16 pair skaters and 22 ice dancers), coming from different ISU members. The response rate was 62% in females and 67% in males. The median age for female skaters was 16 years and for males 18 years (range 12-25 years). All participants started to skate between 3 and 6 years of age and started to compete in national and international competitions when they were between 5 and 7 years old. At the time of this analysis, they had been skating between 9 and 20 years.In females 41 (16.7%), and in males 25 (13.8%) figure skaters reported a stress fracture, which had occurred in the last years of their skating career. The site and the number of stress fractures in female and male junior and senior figure skaters throughout their skating disciplines are shown in Table 1. From all stress fractures reported, 21 (51%) occurred in females and 12 (48%) in male figure skaters during the competitive season, while 20 (49%) stress fractures in females and 13 (52%) in male figure skaters occurred during summer training. Of the investigated skaters 93% trained almost all year round with a 1-2 month break, after the end of a skating season. There were no differences in training duration between the groups of skaters that did and did not report a stress fracture, but all skaters with stress fractures reported changes to their training routine before the occurrence of stress fractures. The overall prevalence of stress fractures in the present study was 16.7% in female and 13.8% in male figure skaters with different prevalence among the figure skating disciplines that can be explained by their different training patterns. Single skaters spend most of their training time practicing different difficult jumps and their legs suffer great impact during the whole training session. In pair skaters the female counterpart has higher stress fracture prevalence than the male, which is comparable to ice dancers. This is probably because pair skaters not only do synchronous jumps but also use throw jumps where the female skater is thrown, while the men stays on the ice. Consequently the lower extremity of the female suffers repeated high impact during landing. Pair skaters and ice dancers practice on different kind of team elements, unison and synchrony. Their lower extremities are less exposed to excessive repetitive impacts compared to single figure skaters (Dubravcic-Simunjak et al., 2003; Moran, 2000), as confirmed by James et al, 2006. Concerning possible contributing factors to stress fractures, all female and male figure skaters reported major changes in their training routine shortly before the occurrence of the stress fracture. In most cases an excessive number of repetitions of jumps and throw jumps, during each training session (up to 30 repetition of each jump), was reported. Galilee-Belfer and Guskiewicz, 2000 also reported that muscular fatigue and sudden changes in training intensity or duration may contribute to stress fracture incidence. In our survey we found that junior skaters, who participate both in junior and senior events, are exposed to greater stress and impacts than juniors who only skate either in junior or senior competitions. Of all senior skaters with stress fractures 5.9% females and 10% males attributed the occurrence to the greater number of competitions and shows, while 20.8% of all female juniors and 33.3% of all male skaters felt that the large number of competitions and shows during one skating season contributed to the occurrence of stress fractures. This is a novel and relevant finding which may have to be taken into account for developing the competition schedule. In conclusion the data suggest that the cumulative risk of stress fractures is high in figure skating, especially among single figure skaters and female pair skaters. In the light of increasing physiological demands from rigorous training and competitive schedules throughout the skating season, prevention deserves more emphasis. Proper education to athletes and coaches about training regimes, together with early recognition of stress fracture symptoms may help to decrease the stress fracture risks. Because of the large number of competitions and shows in a short period of time, it is recommended to critically review the competitive schedule. In addition, rule changes concerning the ages and skaters possibilities to compete in both senior and junior events may have to be considere