Family and Community Health Medical Residency Program for Hypertense Care

The objective of the present study was to evaluate the care provided to patients with systemic arterial hypertension by comparing the basic health units (BHU) of the municipality of Gurupi-TO with and without the family and community health residency program. This is a descriptive, cross-sectional and retrospective research conducted in twelve BHUs. Project approved by the research ethics committee of the University of Gurupi, in which health servants answered the QualiAB assessment and monitoring instrument and the data were tested by the chi-square test to verify if there is a difference in care considering p≤5%. or 0,05. Of the 21 items analyzed, 14 obtained better levels in UBS with MRPFCH. Therefore, it is concluded that BHU with MRPFCH, as single health system policies, have better quality in the care of hypertension

Antifungal and Antivirulence Activities of Hydroalcoholic Extract and Fractions of Platonia insignis Leaves against Vaginal Isolates of Candida Species

Vulvovaginal candidiasis is a common fungal infection in women. In this study, Platonia insignis hydroalcoholic extract (PiHE) and its fractions were evaluated for antifungal and antivirulence activities against vaginal Candida species. Dichloromethane (DCMF) and ethyl acetate fractions (EAF) obtained from PiHE effectively inhibited the pathogen. Electrospray ionization mass spectrometry was used for identifying the main compounds in extracts. Minimal inhibitory and fungicidal concentrations (MIC and MFC, respectively) were determined by a broth microdilution assay. Furthermore, we evaluated the effect of the extract and fractions on the virulence properties of Candida albicans, and their cytotoxicity effect was determined on RAW 264.7 cells. Compounds found in extracts were flavonoid glycosides, mainly derivatives of quercetin and myricetin. Extracts showed antifungal potential, with the lowest MIC value for EAF (1.3 mg/mL) and inhibited Candida adherence and biofilm formation. EAF disrupted 48 h biofilms with an inhibition rate of more than 90%. The extract and its fractions exhibited no cytotoxicity. The antifungal effects were attributed to the ability of these extracts to alter the mitochondrial membrane potential for the release of pro-apoptotic factors in the cytosol. In conclusion, our data suggest that PiHE and EAF could act as novel candidates for the development of new therapeutic treatments against fungal infections