hidden charm decays of X(4014)X(4014) in a D∗Dˉ∗D^{*}\bar{D}^{*} molecule scenario

Inspired by the recent observation of a new structure, $X(4014)$, in the process $\gamma\gamma\to \gamma\psi(2S)$, we evaluate the possibility of assigning $X(4014)$ as a $D^\ast \bar{D}^\ast$ molecular state with $I(J^{PC})=0(0^{++})$ by investigating the hidden charm decays of $X(4014)$. The partial widths of $J/\psi\omega$, $\eta_{c}\eta$ and $\eta_{c}\eta^{\prime}$ channels are evaluated to be about $(0.41\sim 5.00)$, $(2.05\sim7.49)$ and $(0.11\sim0.51)\ \mathrm{MeV}$, respectively. Considering the experimental observation and the present estimations, we proposed to search $X(4014)$ in the $\gamma \gamma \to J/\psi \omega$ process in Belle II.Comment: 7 pages, 5 figures, accepted for publication in Phys. Rev.

Associations of oxytocin with metabolic parameters in obese women of childbearing age

Introduction: The aim of this study was to compare plasma oxytocin levels in obese women of childbearing age with non-obese women of childbearing age, and to investigate the relationship between plasma oxytocin levels and metabolic parameters (including blood glucose, insulin resistance, blood lipid, and blood pressure). Material and methods: A total of 151 obese women of childbearing age and 160 non-obese women of childbearing age were enrolled in this study. Plasma oxytocin levels were measured by electrochemiluminescence immunoassays. Height, body weight, body mass index (BMI), fasting blood glucose (FBG), fasting insulin (FI), homeostasis model assessment for insulin resistance (HOMA-IR), total triglycerides (TG), total cholesterol (TC), low-density lipoprotein-C (LDL-C), high-density lipoprotein-C (HDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured in all subjects. Quantile regression analysis was used to analyse the associations of plasmaoxytocin levels with FBG, FI, HOMA-IR, TG, TC, LDL-C, HDL-C, SBP, and DBP. Results: In obese women of childbearing age, plasma oxytocin levels were lower compared with non-obese controls. After adjusting for age, quantile regression analysis showed that the plasma oxytocin levels were inversely associated with HOMA-IR at the quantile level between 0.27 and 0.79 (i.e. the HOMA-IR level of 2.11 and 3.07, respectively), the plasma oxytocin levels were inversely associated with TC after the quantile level of 0.21 (i.e. the TC level of 3.78 ), and the plasma oxytocin levels were inversely associated with LDL-C at all quantile levels of LDL-C. In addition, the plasma oxytocin levels showed a positive association with HDL-C at all quantile levels of HDL-C.No significant associations were found between the plasma oxytocin levels and FBG, FI, TG, SBP, and DBP. Conclusions: Oxytocin deficiency was common in obese women of childbearing age. Oxytocin showed negative correlation with HOMA-IR, TC, and LDL-C, while it showed positive association with HDL-C. Our findings suggest that oxytocin played an important role in inhibiting metabolic disorders associated with obesity in women of childbearing age.

Coupled-channel D∗K∗−Ds∗ρD^\ast K^\ast -D_s^\ast \rho interactions and the origin of Tcsˉ0(2900)T_{c\bar{s}0}(2900)

Motivated by the recent observation of $T_{c\bar{s}0}(2900)^0$ and $T_{c\bar{s}0}(2900)^{++}$ in the $D_s \pi$ invariant mass distributions, we investigate $D^{\ast}K^{\ast}$ interactions in a coupled-channel approach. We show that the relativistic corrections could be significant for the energy far away from the threshold. Within the hidden local symmetry formalism, a sizable attraction interaction is found in the $J=0$ isospin triplet sector that can form a bound or a virtual state, which is consistent with the experimentally observed $T_{c\bar{s}0}(2900)$. By reproducing a $D_s^*\rho$-$D^*K^*$ bound/virtual state with the pole mass equal to that of the $T_{c\bar{s}0}(2900)$ measured by LHCb in the sector $(I,J)=(1,0)$, we determine the unknown parameter in the loop function, and then search for possible poles in the sectors of $I=1$, $J=1,$ 2 and $I=0$, $J=0$, 1, 2. The predicted resonances provide a useful reference for the future experimental studies of the $(C,S)=(1,1)$ systems and can be also helpful to unravel the nature of the $T_{c\bar{s}0}(2900)$.10Comment: 10 pages, 6 figures, 3 table

Effects of levothyroxine therapy on bone mineral density and bone turnover markers in premenopausal women with thyroid cancer after thyroidectomy

Introduction: We investigated the impact of long-term levothyroxine (LT4) treatment on bone mineral density (BMD) and bone turnover markers (BTMs) in premenopausal women with differentiated thyroid cancer (DTC) after thyroidectomy. Material and methods: Sixty-five premenopausal women who received LT4 therapy at least one year (range, 1.5–9.0 years) after thyroidectomy for DTC and 50 premenopausal women without thyroid diseases were enrolled in this study. We measured the Z-scores of lumbar and hip BMD, serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), intact parathyroid hormone (iPTH), N-terminal propeptide of type 1 N procollagen (P1NP), C terminal telopeptide of type 1 collagen (CTX-1), calcium (Ca), phosphorus (P), vitamin D3, and alkaline phosphatase (ALP) in all participants. Results: In DTC subjects, serum TSH levels were lower, and serum FT4, P1NP, CTX-1, and ALP levels were higher compared with controls. The prevalence of low BMD was higher in DTC subjects than in controls. Multivariate logistic regression analysis showed that serum TSH levels were negatively associated with CTX-1 and ALP. Conclusions: We found a high prevalence of low BMD among premenopausal women who received long-term LT4 therapy for DTC after thyroidectomy. Long-term TSH suppression therapy was a significant risk factor for decreased bone strength, mainly by increasing bone turnover.

The a0(980)a_0(980) in the single Cabibbo-suppressed process Λc→π0ηp\Lambda_c \to \pi^0\eta p

In this work, we have investigated the Cabibbo-suppressed process $\Lambda_c \to \pi^0\eta p$, by taking into account the intermediate scalar state $a_0(980)$, which could be dynamically generated from the $S$-wave pseudoscalar-pseudoscalar interaction within the chiral unitary approach. We have calculated the $\pi^0\eta$ invariant mass distribution, and found that there is a significant structure associated to the $a_0(980)$. We have also roughly estimated the branching fraction $\mathcal{B}(\Lambda_c \to \pi^0\eta p) \approx 10^{-4}$. We encourage our experimental colleagues to measure the process $\Lambda_c \to \pi^0\eta p$ for searching for the state $a_0(980)$ signal in this reaction.Comment: 8 pages, 5 figure

Theoretical study of the open-flavor tetraquark Tcsˉ(2900)T_{c\bar{s}}(2900) in the process Λb→K0D0Λ\Lambda_b\to K^0D^0\Lambda

Recently, the LHCb Collaboration has measured the processes $B^0\to\bar{D}^0D_s^+\pi^-$ and $B^+\to\bar{D}^0D_s^+\pi^+$, where the $D_s^+\pi^-$ and $D_s^+\pi^+$ invariant mass distributions show the significant signals of two new open-flavor tetraquark states $T_{c\bar{s}}(2900)^0$ and $T_{c\bar{s}}(2900)^{++}$, as the two of the isospin triplet. In this work, we have investigated the process $\Lambda_b\to K^0D^0\Lambda$ by taking into account the intermediate nucleon resonance $N^*(1535)$ and the tetraquark state $T_{c\bar{s}}(2900)^0$, which could be dynamically generated by the interactions of the $D^*K^*/D^*_s\rho$ and the pseoduscalar mesons-octet baryons, respectively. Our results show that a clear peak of the open-flavor tetraquark $T_{c\bar{s}}(2900)$ may appear in the $K^0D^0$ invariant mass distribution of the process $\Lambda_b\to K^0D^0\Lambda$, which could be tested by future experiments.Comment: 9 pages, 11 figures, 1 tabl

Chronic Stress Disturbs Metabolome of Blood Plasma and Urine in Diabetic Rats

About 30% of diabetes patients suffer from varying degrees of depression. Diabetes itself is associated with abnormal carbohydrate and energy metabolism. Whether chronic stress-induced depression-like behavior impacts the metabolome of blood plasma and urine in diabetes is not clear. This study aimed to investigate the effect of chronic stress on metabolome of plasma and urine in spontaneously diabetic Goto-Kakizaki (GK) rats. The GK rats were subjected to 8 weeks' chronic unpredictable mild stress (CUMS) to induce depression-like behavior. Metabolome analysis of blood plasma and urine using liquid chromatography mass spectrometry (LC/MS) was performed. Multivariate data analysis was used to evaluate the data. Behavior and biochemical assay confirmed the successful establishment of CUMS-induced depression-like behavior model in rats. Disturbance of 20 plasma metabolites and 16 urine metabolites were altered in CUMS-induced depression GK rats as compared to control ones. These disturbed metabolites were involved in fatty acid metabolism, sphingolipid metabolism, phenylalanine metabolism, citrate cycle, glycolysis, glutathione metabolism, and nicotinate and nicotinamide metabolism. This study suggest that chronic stress-induced depression-like behavior may further disturb diabetes-itself energy metabolome. The plasma and urine lipid metabolites monitoring may be useful for early detection of depression in patients with diabetes mellitus

Milk fat globule membrane promotes brain development in piglets by enhancing the connection of white matter fiber trace

IntroductionBrain development during infancy is crucial for later health and development. Although Milk Fat Globule Membrane (MFGM) has been demonstrated to enhance brain development, further investigation is needed to determine the optimal dose.MethodsIn this study, 80 piglets aged 2 days were randomly assigned to four groups: Control group, MFGM-L (1.74 g MFGM per 100 g diet), MFGM-M (4.64 g MFGM per 100 g diet), and MFGM-H (6.09 g MFGM per 100 g diet). Daily body weight and milk intake of the piglets were recorded until 31 days postnatal. Learning and memory abilities were evaluated using the spatial T-maze test on day 15. MRI analysis was conducted to assess functional and structural changes in brain tissues. Additionally, mRNA and protein expression of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NTF-3) in the hippocampus and prefrontal cortex were evaluated.ResultsThe results indicated that the MFGM supplemented diet significantly improved the accuracy of the piglets in the T-maze test, with the MFGM-L group exhibiting the best performance. MRI showed no volumetric differences in the gray and white matter between the groups. However, the fractional anisotropy in the left and right hippocampus of piglets in the MFGM-L group was significantly higher than in the other three groups. Furthermore, there was a strong correlation between the accuracy of the T-maze test and hippocampal fractional anisotropy.DiscussionThe MFGM supplemented diet also increased the expression of BDNF in the cerebral cortex. However, the changes in BDNF were not consistent with the results of the T-maze test. In conclusion, adding 1.74 g MFGM per 100 g diet can significantly improve neonatal piglets’ learning and memory abilities, potentially by enhancing the connection of white matter fiber bundles in the brain

Plant growth retardation and conserved miRNAs are correlated to hibiscus chlorotic ringspot virus infection

10.1371/journal.pone.0085476PLoS ONE812-POLN

Quantum entanglement and disentanglement of multi-atom systems

We present a review of recent research on quantum entanglement, with special emphasis on entanglement between single atoms, processing of an encoded entanglement and its temporary evolution. Analysis based on the density matrix formalism are described. We give a simple description of the entangling procedure and explore the role of the environment in creation of entanglement and in disentanglement of atomic systems. A particular process we will focus on is spontaneous emission, usually recognized as an irreversible loss of information and entanglement encoded in the internal states of the system. We illustrate some certain circumstances where this irreversible process can in fact induce entanglement between separated systems. We also show how spontaneous emission reveals a competition between the Bell states of a two qubit system that leads to the recently discovered "sudden" features in the temporal evolution of entanglement. An another problem illustrated in details is a deterministic preparation of atoms and atomic ensembles in long-lived stationary squeezed states and entangled cluster states. We then determine how to trigger the evolution of the stable entanglement and also address the issue of a steered evolution of entanglement between desired pairs of qubits that can be achieved simply by varying the parameters of a given system.Comment: Review articl