2-Amino-6-(naphthalen-1-yl)-4-phenyl­pyridine-3-carbonitrile

In the title compound, C22H15N3, the naphthyl ring system makes dihedral angles of 67.40 (2) and 59.80 (3)° with the pyridyl and phenyl rings, respectively. In the crystal, the mol­ecules are connected via inter­molecular N—H⋯N hydrogen bonds, forming a three-dimensional network

Poly[di-μ2-chlorido-μ2-(1,4-dioxane-κ2 O:O′)-cadmium(II)]

In the title complex, [CdCl2(C4H8O2)]n, two different CdII ions are present, one in a general position and one with site symmetry 2. The CdII ions are coordinated by two O atoms from two 1,4-dioxane ligands and four chloride anions in a slightly distorted octa­hedral geometry and is connected to neighboring CdII ions by two bridging chloride anions, generating infinite linear chains along the a axis. These chains are further inter­connected by bridging 1,4-dioxane ligands, affording a three-dimensional network

5-(4-Methyl­piperazin-1-yl)-2-nitro­aniline

In the title compound, C11H16N4O2, the dihedral angle between the benzene ring and the plane of the four carbon atoms in the piperazine ring is 12.17 (3)°; the latter ring adopts a chair conformation. An intramolecular N—H⋯O hydrogen bond generates an S(6) ring. In the crystal, the molecules are linked by N—H⋯N hydrogen bonds, forming chains

Objective assessment of urban built environment related to physical activity — development, reliability and validity of the China Urban Built Environment Scan Tool (CUBEST)

Background: Some aspects of the neighborhood built environment may influence residents’ physical activity, which in turn, affects their health. This study aimed to develop an urban built environment evaluation tool and conduct necessary reliability and validity tests. Methods: A 41-item urban built environment scan tool was developed to objectively assess the neighborhood built environment features related to physical activity. Six neighborhoods in Hangzhou were selected from three types of administrative planning units. A pair of auditors independently assessed all of the 205 street segments at the same time. Half of the segments (n = 104) were audited twice by the same auditor after a two-week time interval. Inter-rater reliability was assessed by comparing the audits of paired observers, while intra-rater reliability was evaluated by comparing an auditor’s repeated assessments of the same segments. The construct validity was tested using factor analysis. Results: The inter-rater reliability for most items was above 0.8. The intra-rater reliability for most items was above 0.4, and was lower than corresponding inter-rater reliability. Six factors were extracted by factor analysis and the factor loading matrix showed good construct validity. Conclusions: The CUBEST is a reliable and valid instrument that can be used to assess the physical activity-related built environment in Hangzhou, and potentially other cities in China

2-Methyl­sulfanyl-4-(3-pyrid­yl)pyrimidine

In the title compound, C10H9N3S, the dihedral angle between the aromatic rings is 8.09 (14)°. In the crystal, a C—H⋯N interaction links the molecules, forming chains

On Inhomogeneous Infinite Products of Stochastic Matrices and Applications

With the growth of magnitude of multi-agent networks, distributed optimization holds considerable significance within complex systems. Convergence, a pivotal goal in this domain, is contingent upon the analysis of infinite products of stochastic matrices (IPSMs). In this work, convergence properties of inhomogeneous IPSMs are investigated. The convergence rate of inhomogeneous IPSMs towards an absolute probability sequence $\pi$ is derived. We also show that the convergence rate is nearly exponential, which coincides with existing results on ergodic chains. The methodology employed relies on delineating the interrelations among Sarymsakov matrices, scrambling matrices, and positive-column matrices. Based on the theoretical results on inhomogeneous IPSMs, we propose a decentralized projected subgradient method for time-varying multi-agent systems with graph-related stretches in (sub)gradient descent directions. The convergence of the proposed method is established for convex objective functions, and extended to non-convex objectives that satisfy Polyak-Lojasiewicz conditions. To corroborate the theoretical findings, we conduct numerical simulations, aligning the outcomes with the established theoretical framework

Epigenetic hypomethylation and upregulation of GD3s in triple negative breast cancer.

Background: Breast cancer remains a major health problem in the world. Triple-negative breast cancer (TNBC) is an aggressive subtype with very poor prognosis. Up to now, the mechanism behind TNBC\u27s activity is still unclear and no candidate drug target has been identified. Thus, it is of critical importance to elucidate the pathways in TNBC and identify the relevant biomarkers. Recent studies showed that ganglioside D3 synthase (GD3s) played a very important role in development of cancers. However, the physiological functions and associated pathways of GD3s in TNBC are still unclear. Methods: Results: Conclusions: In summary, these results suggest that GD3s may be a potential biomarker and drug target in treatment of TNBC

TMRT observations of 26 pulsars at 8.6 GHz

Integrated pulse profiles at 8.6~GHz obtained with the Shanghai Tian Ma Radio Telescope (TMRT) are presented for a sample of 26 pulsars. Mean flux densities and pulse width parameters of these pulsars are estimated. For eleven pulsars these are the first high-frequency observations and for a further four, our observations have a better signal-to-noise ratio than previous observations. For one (PSR J0742-2822) the 8.6~GHz profiles differs from previously observed profiles. A comparison of 19 profiles with those at other frequencies shows that in nine cases the separation between the outmost leading and trailing components decreases with frequency, roughly in agreement with radius-to-frequency mapping, whereas in the other ten the separation is nearly constant. Different spectral indices of profile components lead to the variation of integrated pulse profile shapes with frequency. In seven pulsars with multi-component profiles, the spectral indices of the central components are steeper than those of the outer components. For the 12 pulsars with multi-component profiles in the high-frequency sample, we estimate the core width using gaussian fitting and discuss the width-period relationship.Comment: 33 pages, 49 figures, 5 Tables; accepted by Ap