The Kinematics of CIV in Star-Forming Galaxies at z~1.2

We present the first statistical sample of rest-frame far-UV spectra of star-forming galaxies at z~1. These spectra are unique in that they cover the high-ionization CIV{\lambda}{\lambda}1548, 1550 doublet. We also detect low-ionization features such as SiII{\lambda}1527, FeII{\lambda}1608, AlII{\lambda}1670, NiII{\lambda}{\lambda}1741, 1751 and SiII{\lambda}1808, and intermediate-ionization features from AlIII{\lambda}{\lambda}1854, 1862. Comparing the properties of absorption lines of lower- and higher- ionization states provides a window into the multi-phase nature of circumgalactic gas. Our sample is drawn from the DEEP2 survey and spans the redshift range 1.01 < z < 1.35 ( = 1.25). By isolating the interstellar CIV absorption from the stellar P-Cygni wind profile we find that 69% of the CIV profiles are blueshifted with respect to the systemic velocity. Furthermore, CIV shows a small but significant blueshift relative to FeII (offset of the best-fit linear regression -76 $\pm$ 26 km/s). At the same time, the CIV blueshift is on average comparable to that of MgII{\lambda}{\lambda}2796, 2803. At this point, in explaining the larger blueshift of CIV absorption at the ~ 3-sigma level, we cannot distinguish between the faster motion of highly-ionized gas relative to gas traced by FeII, and filling in on the red side from resonant CIV emission. We investigate how far-UV interstellar absorption kinematics correlate with other galaxy properties using stacked spectra. These stacking results show a direct link between CIV absorption and the current SFR, though we only observe small velocity differences among different ionization states tracing the outflowing ISM.Comment: 21 pages, 14 figures, ApJ, accepte

Reparameterized Variational Rejection Sampling

Traditional approaches to variational inference rely on parametric families of variational distributions, with the choice of family playing a critical role in determining the accuracy of the resulting posterior approximation. Simple mean-field families often lead to poor approximations, while rich families of distributions like normalizing flows can be difficult to optimize and usually do not incorporate the known structure of the target distribution due to their black-box nature. To expand the space of flexible variational families, we revisit Variational Rejection Sampling (VRS) [Grover et al., 2018], which combines a parametric proposal distribution with rejection sampling to define a rich non-parametric family of distributions that explicitly utilizes the known target distribution. By introducing a low-variance reparameterized gradient estimator for the parameters of the proposal distribution, we make VRS an attractive inference strategy for models with continuous latent variables. We argue theoretically and demonstrate empirically that the resulting method--Reparameterized Variational Rejection Sampling (RVRS)--offers an attractive trade-off between computational cost and inference fidelity. In experiments we show that our method performs well in practice and that it is well-suited for black-box inference, especially for models with local latent variables.Comment: 26 pages & 10 figure

Operational performance assessment of decentralised energy and district heating systems

District heating systems can contribute to reducing the UK’s CO2 emissions. This thesis investigates the operational performance of current district heating (DH) systems with the existing and a possible future energy sector. The main contributions to knowledge are: Operational, financial and exergy performance assessments of three functioning DH systems and one decentralised energy (DE) technology A methodology to optimise a DH system in a resource efficient and cost effective way The aims of DH systems are to provide heat, reduce CO2 emissions, ensure energy security by operating in a resource efficient way and to tackle fuel poverty. However, the case studies in this project confirm that DH systems operate poorly in the UK. This is largely because of the heat losses from the DH network to the soil being high and the plant operation being suboptimal. Four case studies were analysed. The 785 room Strand Palace hotel has two 250 kWe combined heat and power (CHP) engines set to modulate following the hotel’s electricity consumption and providing approximately 90% of this annual demand. It was found that the CHP engines never operate at full load throughout a full day, firstly because the plant cannot export electricity to the grid and secondly the system is not fitted with a thermal store. Financial analysis revealed that the hotel does not reduce its heating cost by operating the CHP engines, but that the energy service company (ESCo) makes £77,000 net operating income per year. Elmswell in Suffolk (UK) is a low heat density DH system that generates heat with a 2008 biomass boiler and pumps it to 26 terraced and semi-detached dwellings. It was found that 39% of its heat is lost to the soil and that the natural gas boiler generates 45% of the heating load and operates with a seasonal efficiency of 65%. The heat losses to the soil for this system were compared to a DH system of higher heat density, Loughborough University, with a lower heat loss of 22% to the soil. In August 2011, Loughborough University installed a 1.6 MWe CHP engine to operate with four 3 MWth natural gas boilers to supply heat to its DH network. A study undertaken demonstrated that by adding a 2 MWe CHP engine with a thermal storage instead of a 1.6 MWe CHP engine on its own could further increase the CO2 emissions savings from 8% to 12.4%. The energy centre at Pimlico District Heating Undertaking (PDHU) includes a gas fired cogeneration plant that supplies heat to 3 schools, 3,256 dwellings and 55 commercial units. It also benefits from a 2,500 m3 thermal store. Every component of PDHU was investigated in detail and its current operation was optimised and compared to a selection of new operating scenarios. It was found that: i) The thermal store operated with 93% thermal efficiency and was not used to reduce the energy consumption or to enable more cogeneration, ii) The CHP engines were undersized and generated only 18% of the required heat in 2012, iii) The boilers modulate and £ 70,000 could be saved per year by setting them to operate at full load by making use of the thermal store, iv) By installing an open-loop heat pump using the river Thames, PDHU could then guarantee to comply with current and likely future policies impacts by setting the energy plant to operate in CHP mode or as an electricity consumer at defined times to benefit from low energy utility costs and to minimise CO2 emissions. A comparison of selected performance metrics was then undertaken and it was found that none of the three DH systems operate in a resource efficient way and that the heating cost could be reduced further by optimising the operation of the systems. To do this, a new optimisation methodology is proposed by maximising their exergy efficiency in addition to maximising their overall energy efficiency and CO2 emissions reduction

Expression of MHC Class II Antigens During Xenopus Development

Larval and adult forms of the amphibian Xenopus differ in their MHC class II .expression. In tadpoles, class II epitopes can be detected by monoclonal antibodies only on B cells, macrophages (whatever their location), spleen reticulum, thymus epithelium, and the pharyngobuccal cavity. In contrast, all adult T cells express class II on their surface. The transitions in class II expression occur at metamorphosis and are accompanied by other changes. The skin is invaded by class II positive dendritic cells, and the skin glands differentiate and also express class II. The gut, which expressed class II in discrete areas of the embryonic tissue, becomes invaded with B cells, and its epithelium also becomes class II positive

Theoretical mass sensitivity of Love wave and layer guided acoustic plate mode sensors

A model for the mass sensitivity of Love wave and layer guided shear horizontal acoustic plate mode (SH–APM) sensors is developed by considering the propagation of shear horizontally polarized acoustic waves in a three layer system. A dispersion equation is derived for this three layer system and this is shown to contain the dispersion equation for the two layer system of the substrate and the guiding layer plus a term involving the third layer, which is regarded as a perturbing mass layer. This equation is valid for an arbitrary thickness perturbing mass layer. The perturbation, Δν, of the wave speed for the two-layer system by a thin third layer of density, ρp and thickness Δh is shown to be equal to the mass per unit area multiplied by a function dependent only on the properties of the substrate and the guiding layer, and the operating frequency of the sensor. The independence of the function from the properties of the third layer means that the mass sensitivity of the bare, two-layer, sensor operated about any thickness of the guiding layer can be deduced from the slope of the numerically or experimentally determined dispersion curve. Formulas are also derived for a Love wave on an infinite thickness substrate describing the change in mass sensitivity due to a change in frequency. The consequences of the various formulas for mass sensing applications are illustrated using numerical calculations with parameters describing a (rigid) poly(methylmethacrylate) wave-guiding layer on a finite thickness quartz substrate. These calculations demonstrate that a layer-guided SH–APM can have a mass sensitivity comparable to, or higher, than that of Love waves propagating on the same substrate. The increase in mass sensitivity of the layer guided SH–APMs over previously studied SH–APM sensors is of significance, particularly for liquid sensing applications. The relevance of the dispersion curve to experiments using higher frequencies or frequency hopping and to experiments using thick guiding layers is discussed

IVIG Delays Onset in a Mouse Model of Gerstmann-Sträussler-Scheinker Disease

Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and PrP neurotoxicity in vitro, it remained unknown whether IVIG could reduce amyloid plaque pathology in vivo and be used to effectively treat animals with prion diseases. In this study, we used Gerstmann-Sträussler-Scheinker (GSS)-Tg (PrP-A116V) transgenic mice to test IVIG efficacy since amyloid plaque formation played an important role in GSS pathogenesis. Here, we provided strong evidence that demonstrates how IVIG could significantly delay disease onset, elongate survival, and improve clinical phenotype in Tg (PrP-A116V) mice. Additionally, in treated animals, IVIG could markedly inhibit PrP amyloid plaque formation and attenuate neuronal apoptosis at the age of 120 days in mice. Our results indicate that IVIG may be a potential, effective therapeutic treatment for GSS and other prion diseases