Prototype solar power satellite options

The choice of options for the prototype solar power satellite is addressed relative to risk and cost. Emphasis is placed on the reduction of the risk of failure. Risk is the program cost multiplied by the reduction in probability of program success due to the risky action. Four classes of risk are identified. It is suggested that prototyping would reduce the technical risk as well as reduce the effects of the other three types of risk by allowing them to be quantified earlier. Prototype demonstration requirements addressed include electromagnetic power link feasibility demonstration, component integration verification, construction technology verification, and cost performance verification. Specific prototype requirements are listed and prototyping options are given in tabular form

High-power microwave optics for flexible power transmission systems

A large concave microwave mirror near the transmitter can magnify the apparent size of the Earth as seen from a phased array, and vice versa, permitting a small phased array to be coupled to a small rectenna while preserving the transmission efficiency (the reflection loss is slight) and peak power densities characteristic of the reference system. This augmentation of the phased array aperture with a large mirror gives the system greater resolution (in the optical sense), and opens new degrees of freedom in SPS design. The consequences of such an approach for a prototype satellite were explored. Its consequences for a mature SPS are discussed

Token Wars: How the SEC Can Learn to Embrace Utility Tokens

Tired of the power that mega platforms wield over the web, a growing chorus of internet users has hailed the arrival of blockchain technology, believing it can be used to build a new internet. Called “Web 3.0” by some, the new internet would allow users to exchange goods and services—digital currencies, cloud computing power, data storage—without needing a central intermediary to validate transactions. Instead, users would transact through decentralized platforms that use consensus-based mechanisms to verify users’ exchanges. And rather than rely on fiat money, users would use the platforms’ native currencies, called “utility tokens,” as the media of exchange. Utility tokens also serve another purpose. Because rebuilding the internet is a costly endeavor, the groups developing decentralized platforms have turned toward selling utility tokens to fundraise their efforts. However, the issuance of utility tokens has caught the eye of the Securities and Exchange Commission (“SEC”)—the federal agency in charge of enforcing the nation’s securities laws—which has asserted its authority over utility token issuances. Unfortunately, the SEC’s oversight lacks transparency, and the agency’s rules do not protect investors against the risks they face in the digital economy. This Note calls for a bright-line test that would entitle issuers of utility tokens to a rebuttable presumption that the securities laws do not apply to sales of the issuers’ utility tokens if their tokens meet each of the test’s factors. This Note also advocates for modernizing the Regulation D private placement exemption so that it can address the realities implicit in token purchases. The changes pushed by this Note aim to quell developers’ uncertainty and foster the ingenuity behind Web 3.0

Rolling and sliding of a nanorod between two planes: Tribological regimes and control of friction

The motion of a cylindrical crystalline nanoparticle sandwiched between two crystalline planes, one stationary and the other pulled at a constant velocity and pressed down by a normal load, is considered theoretically using a planar model. The results of our model calculations show that, depending on load and velocity, the nanoparticle can be either rolling or sliding. At sufficiently high normal loads, several sliding states characterized by different friction forces can coexist, corresponding to different orientations of the nanoparticle, and allowing one to have low or high friction at the same pulling velocity and normal load.Comment: 5 figure

Potential novel pharmacological therapies for myocardial remodelling

Left ventricular (LV) remodelling remains an important treatment target in patients after myocardial infarction (MI) and chronic heart failure (CHF). Accumulating evidence has supported the concept that beneficial effects of current pharmacological treatment strategies to improve the prognosis in these patients, such as angiotensin-converting enzyme (ACE) inhibition, angiotensin type 1 receptor blocker therapy, and beta-blocker therapy, are related, at least in part, to their effects on LV remodelling and dysfunction. However, despite modern reperfusion therapy after MI and optimized treatment of patients with CHF, LV remodelling is observed in a substantial proportion of patients and is associated with an adverse clinical outcome. These observations call for novel therapeutic strategies to prevent or even reverse cardiac remodelling. Recent insights from experimental studies have provided new targets for interventions to prevent or reverse LV remodelling, i.e. reduced endothelial nitric oxide (NO) synthase-derived NO availability, activation of cardiac and leukocyte-dependent oxidant stress pathways, inflammatory pathway activation, matrix-metalloproteinase activation, or stem cell transfer and delivery of novel paracrine factors. An important challenge in translating these observations from preclinical studies into clinical treatment strategies relates to the fact that clinical studies are designed on top of established pharmacological therapy, whereas most experimental studies have tested novel interventions without concomitant drug regimens such as ACE inhibitors or beta-blockers. Therefore, animal studies may overestimate the effect of potential novel treatment strategies on LV remodelling and dysfunction, since established pharmacological therapies may act, in part, via identical or similar signalling pathways. Nevertheless, preclinical studies provide essential information for identifying potential novel targets, and their potential drawbacks, and are required for developing novel clinical treatment strategies to prevent or reverse LV remodelling and dysfunctio

Silencing of ASC in Cutaneous Squamous Cell Carcinoma.

Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an important adaptor protein for inflammasome activation, mediating the secretion of protumorigenic innate cytokines. However, ASC is also known to trigger apoptosis in tumor cells, acting as a tumor-suppressor gene, which is lost in several human cancers. The aim of this study was to evaluate the clinical significance of ASC in human cutaneous squamous cell carcinoma (SCC). Initially, ASC expression was immunohistochemically evaluated in non-metastic and metastatic SCC. While ASC expression does not correlate with metastatic potential, it correlates with the degree of dedifferentiation. Using methylation specific PCR we were able to demonstrate ASC silencing by promotor specific methylation and impaired inflammasome function in methylated cell lines, linking epigenetic modifications to innate immune activation in keratinocytes. Interestingly, upon ASC restoration by treatment with demethylating agents, we were able to restore AIM2 and NLRP3 activation. In summary, loss of ASC driven tumor development is counterbalanced in the identical cell by the inhibition of pro-tumorigenic inflammation in the tumor cell itself

Molecular machinery and manufacturing with applications to computation

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Architecture, 1991.Vita.Includes bibliographical references (p. 469-487).by K. Eric Drexler.Ph.D