How Historical and Current Management Practices have Affected Milk River Riparian Habitat in Northcentral Montana

Riparian and wetland communities support the greatest concentration of plants and animals, yet only constitute 4 percent of Montana’s land cover.  Because they are more productive than surrounding uplands, they are attractive to livestock and wildlife as they provide important forms of cover and forage.  For private and public land managers interested in maintaining long-term integrity and functionality of riparian and wetland communities on their lands, management strategies that accommodate on-site resource needs must be implemented.  Determining habitat types and their associated community types on these sites can help identify historical impacts that have affected community type succession, and how current management strategies could be affecting the trend towards one seral stage or another.  Both natural and artificial disturbances can affect community type succession, yet succession from one type to another can take several years and even decades.  Thus, changes from year to year can be very subtle, and as land managers implement current management practices, they may overlook the visual cues indicating these trends, simply because these processes can be very slow.  This presentation summarizes an evaluation of a riparian area located in the Milk River Valley in Northcentral Montana. An illustration of how historical impacts have affected community type succession, and how this site has been affected by a significant change in management practices that occurred over 20 years ago, is provided. Depending on what goals are desired for this site will determine if a change in current management practices is warranted

Teaching Resident Self-Assessment Through Triangulation of Faculty and Patient Feedback

Problem: To accurately determine one\u27s ability in any clinical competency, an individual must be able to self-assess performance and identify personal limitations. Existing research demonstrates that physicians of all levels are unreliable self-assessors. This poses a concern in medical practice, which requires continuous updates to clinical competencies and awareness of personal limitations. Few published studies examine graduate medical education curricula designed to develop self-assessment skills. Intervention: Conceptual models, such as self-determination theory, suggest that self-assessment is most effectively learned through reflective processes. The Family Medicine Residency Program at Lehigh Valley Health Network developed a learner-centered competency assessment process that integrates advising and performance review. The multisource, observable behavior-based process encourages conversation between resident and advisor. Utilizing feedback from clinical preceptors and patient surveys, advisors guide residents in determining individual learning needs in core competency areas, including relationship-centered care. Development of medical learners\u27 capacity to form relationships is one means to improving the patient experience. Context: This retrospective case study evaluates the accuracy of senior residents\u27 self-assessment in relationship-centered care compared with that of junior residents. The study population includes the 34 residents enrolled from AY 2009–2012. Data sets represent specific 6-month periods and have 3 component scores—Self, Faculty, and Patient—which were triangulated to determine concordance rates by postgraduate year level. Outcome: The concordance rate among first-years was 26.7%, whereas third-years saw 60.0% concordance. A discordance analysis found the Patient score most often deviated from the other 2 scores, whereas the Faculty score was never the sole dissenter. When all 3 scores differed, the Self score frequently fell between the other 2 scores. Lessons Learned: The principles of self-determination theory provide a valuable framework for understanding the development of residents\u27 intrinsic motivation to become lifelong learners. The trend in improved concordance rates among senior residents suggests that prompting learners to triangulate feedback from multiple sources can lead to a shift in perspective about competency. Further study is needed to determine whether our results are generalizable to other competencies and educational setting

In Vitro and In Vivo Characterization of a Fully Felinized Therapeutic Anti-Nerve Growth Factor Monoclonal Antibody for the Treatment of Pain in Cats

BACKGROUND: Limited options are available for the treatment of pain in cats. Monoclonal antibodies (mAbs) that neutralize nerve growth factor (NGF) have demonstrated analgesic capacity in rodent models, people with osteoarthritis, and dogs with degenerative joint disease. HYPOTHESIS/OBJECTIVES: This study describes the design and characterization of a fully felinized anti-NGF monoclonal antibody. In vitro potency, pharmacokinetics, and the ability of the antibody to treat pain in a self-resolving, acute inflammation model were investigated in cats. ANIMALS: Thirty-eight cats at a research colony at Charles River Laboratories, Ireland. METHODS: Felinized anti-NGF mAb, NV-02, was produced using a complementary DNA (cDNA)-based method (PETization). Purified NV-02 was tested for affinity, potency, and immunoreactivity in vitro, then for safety and plasma pharmacokinetic distribution in vivo, and analgesic efficacy in a model of kaolin-induced inflammatory pain. RESULTS: Anti-NGF mAb, NV-02 neutralized NGF with high affinity and potency and did not bind complement. NV-02-administered SC had a plasma half-life of 7-15 days and was well tolerated at dosages up to 28 mg/kg. A dosage of 2 mg/kg NV-02 SC significantly decreased signs of lameness on day 2 (P = .0027), day 3 (P = .016), day 4, (P = .0063), day 5 (P = .0085), day 6 (P = .0014), and day 7 (P = .0034) after induction of inflammation. CONCLUSIONS AND CLINICAL IMPORTANCE: The high affinity, long plasma half-life, safety, and analgesic efficacy of felinized anti-NGF mAb (NV-02) support further investigation of the analgesic potential of this antibody in the cat

Muons as Local Probes of Three-body Correlations in the Mixed State of Type-II Superconductors

The vortex glass state formed by magnetic flux lines in a type-II superconductor is shown to possess non-trivial three-body correlations. While such correlations are usually difficult to measure in glassy systems, the magnetic fields associated with the flux vortices allow us to probe these via muon-spin rotation measurements of the local field distribution. We show via numerical simulations and analytic calculations that these observations provide detailed microscopic insight into the local order of the vortex glass and more generally validate a theoretical framework for correlations in glassy systems.Comment: 4+ pages, high-quality figures available on reques