1 research outputs found
The non-conventional use of 99mTc-Tetrofosmine for dynamic hepatobiliary scintigraphy
BACKGROUND: Classic dynamic hepatobiliary scintigraphy
(DHBS) is commonly performed with 99mTc-Iminodiacetic Acid
(IDA) derivatives and represents a non-invasive diagnosis method
for biliary dyskinesia, fistulas, surgical anastomosis, etc (1).
This study assesses the possibility of performing DHBS with
99mTc-Tetrofosmine (TF), a radiopharmaceutical (RF) dedicated
to myocardial perfusion scintigraphy (MPS), but being excreted
through the liver. The possibility to use 99mTc-TF for DHBS may
be important in situations when the standardized RF for this
procedure (IDA derivatives) is not available.
MATERIAL AND METHODS: We performed DHBS for 30 patients
referred for investigation by internal medicine and surgery
departments. The patients had been fasting for12 hours. The
dynamic investigation started simultaneously with the intravenous
(IV) administration of 37–110 MBq (1–3 mCi) 99mTc-TF.
Dynamic images were recorded for 30–45 minutes, one image
per minute, followed by static scintigraphy at 1 h, 1.5 h, 2 h,
and 3 h after IV injection.
RESULTS: The quality of scintigraphic images of the liver and
biliary tree obtained at DHBS with 99mTc-TF ensured the correct
diagnosis of biliary dyskinesia, stasis, stenosis, and fistulas.
CONCLUSIONS: DHBS using 99mTc-TF is justified by the image
quality and by the good cost/benefits ratio. Because the IDA
derivatives are not always available, this finding may be important
for medical practice. 99mTc-TF evacuated through the bile
duct allows DHBS interpretation, while the necessary dose is
approximately 8 to 20 times smaller than that used for myocardial
perfusion scintigraphy.
Nuclear Med Rev 2011; 14, 2: 79–8