Study of the efficacy of Pathadi Ghanavati with Lajamanda in the management of Aamatisara

Acute Diarrhoea is an important public health problem worldwide. The World Health Organization estimates that there are more than 1000 million cases of Acute Diarrhoea. Loose motion less than 2 weeks that labelled as Acute Diarrhoea. Diarrhoea is described in Ayurvedic classics with the name of ‘Atisara’. It means passing of excessive flow of watery stool through anus. Most important factor in the pathogenesis of Aamatisara is Mandagni. In present study 50 patients of Aamatisara were selected from OPD and IPD of Kayachikitsa department. For the clinical study Pathadi Ghanavati and Lajamanda was selected as the trial drug which was given for the duration of 7 days in the dose of 1gm twice a day. It was observed that 32% patients were from the age group 51-60 years, 70% were females, 62% were from lower-middle socio economic class. Sama Jivha was found in all the patients. Among results loose motion showed 98.75% relief, 97.82% showed improvement in Udarashoola, 97.43% improvement in Agnimandya and Daurbalya each, 100% relief was seen in Aruchi. All the symptoms showed highly significant results. Hence it can be concluded that Pathadi Ghanavati and Lajamanda is very effective remedy in the patients of Aamatisara

The Kasaghna effect of Akshawaleha in the management of Rajayakshma w.s.r. to Pulmonary Tuberculosis - A Case Study

In modern era Rajayakshma can be correlated to Tuberculosis. Rajayakshma is a Madhyama Rogamarga Vyadhi manifested Shosha. Though there is a difference in the pathogenesis of Rajayakshma and Pulmonary Tuberculosis, the clinical picture of both is quite similar. It is a major public health problem in India due to the environmental changes, changes in behavioural, diet habits, poor quality of life, population explosion, under nutrition and lack of awareness about cause of disease and modern life style. Ayurveda can provide the satisfactory health service due to its comprehensive capacity of attaining all types of Pathological changes. To fulfil the applied aspect of these basic principles the symptoms of Rajayakshma have been under taken for study. Here we done a study on a patient of Rajayakshma to rule out the Kasaghna effect of Akshawaleha in the management

The effect of Gandharvahasta Sneha with Dashmula Kwatha in the management of hyperamonaemia in alcoholic liver cirrhosis w.s.r. to Dushyodara/Sannipatodara - A Case Study

A 45yrs aged male patient presenting with Udarvriddhi (abdominal distention), Kshudhamandya (decreased appetite), Dourbalya (gen. weakness), Ubhaypadshoth (bilateral pedal edema) diagnosed as Udarvyadhi (ascites) was brought to Dr. M. N. Agashe Charitable Hospital, Satara. Patient was treated with an integrated approach of ayurveda. According to Ayurveda, treatment of Udar is Nityavirechana (purgative), Agnideepan (increase appetite), Balaprapti (increase strength), Yakrituttejjak (stimulant for hepatic function and external application of Arkapattbandhan (belt made by leaves of Calotropis procera). In this study we used the Gandharvahasta Sneha with Dashmula Kwatha as purgative. Appreciable results were observed in the form of reduction in abdominal girth, decreased pedal edema, increased appetite, increased strength and significant changes in investigations

Clinical Study of Chakramardadi Pralepa in the management of Dadru Kushta

Background: Skin is the largest organ of human body. Its size and external location makes it susceptible to a wide variety of disorders. In recent years there has been increase in incidence of skin problem due to various reasons like Poverty, Poor sanitation, Unhygienic condition, Pollution etc. Dadru is one among Kushta Roga affecting all the age of population. It is Kapha-Pitta Pradhan Vyadhi and presents clinically with the features of Kandu, Raga, Pidika, Daha, Rookshata, Udgata Mandala etc. and can be correlated with Tinea infection. Management of Dadru includes Shodhana, Shaman and Bahiparimarjan Chikitsa. Chakramarda is a wild crop grows in most part of India and it is known as Ringworm plant. So here in this study Chakramadadi Pralepa was used to evaluate the efficacy in Dadru

Clinical efficacy of Kasakartari Gutika in the management of Kasa in Tamaka Shwasa w.s.r. to Bronchial Asthma

Background: The disease Kasa and Tamaka Shwasa mentioned by Acharya Charaka separately, both the disease are originating from Pranavaha Srotas and can damage Pranavaha Srotas permanently. Especially in Tamaka Shwasa Vyadhi, Kasa is very common as a prominent symptom. In fact patient gets more detoriated after onset of Kasa Vega and fills better when it gets subside. Though Tamaka Shwasa Vyadhi is Pitta Samudbhava, Kapha and Vata are always predominant factors. The Strotorodha made by Styana Kapha provocate Vayu excessively and result into Kasa Vega as symptom. According to Ayurveda the contain of Kasakartari Gutika is act as Kasa-shwashar property and hence for present study Kasakartari Gutika was selected as trial drug for treating the patient of Kasa in Tamaka Shwasa. Aim: To study the efficacy of ‘Kasakartari Gutika’ in the management of Kasa in Tamaka Shwasa w.s.r. to Bronchial Asthma. Material and Methods: Total 30 paients of Kasa in Tamaka Shwasa from OPD and IPD unit of Dr. M. N. Agashe Hospital, Satara, were selected and treated with Kasakartari Gutika 1gm B.D. for the duration of 2 month. Result: Maximum 81.81% relief was observed in Kshudhamandya and 80.64% relief was observed in Ayasenshwasa and 77.5% relief was observed in Kasa. Conclusion: The compound formulation ‘Kasakartari Gutika’ was found as an effective remedy for Kasa in Tamaka Shwasa. The parameters like Kasa, Ayasenshwasa and Kshudhamandya shows that they are highly significant result

A Protective Role for ELR+ Chemokines during Acute Viral Encephalomyelitis

The functional role of ELR-positive CXC chemokines in host defense during acute viral-induced encephalomyelitis was determined. Inoculation of the neurotropic JHM strain of mouse hepatitis virus (JHMV) into the central nervous system (CNS) of mice resulted in the rapid mobilization of PMNs expressing the chemokine receptor CXCR2 into the blood. Migration of PMNs to the CNS coincided with increased expression of transcripts specific for the CXCR2 ELR-positive chemokine ligands CXCL1, CXCL2, and CXCL5 within the brain. Treatment of JHMV-infected mice with anti-CXCR2 blocking antibody reduced PMN trafficking into the CNS by >95%, dampened MMP-9 activity, and abrogated blood-brain-barrier (BBB) breakdown. Correspondingly, CXCR2 neutralization resulted in diminished infiltration of virus-specific T cells, an inability to control viral replication within the brain, and 100% mortality. Blocking CXCR2 signaling did not impair the generation of virus-specific T cells, indicating that CXCR2 is not required to tailor anti-JHMV T cell responses. Evaluation of mice in which CXCR2 is genetically silenced (CXCR2−/− mice) confirmed that PMNs neither expressed CXCR2 nor migrated in response to ligands CXCL1, CXCL2, or CXCL5 in an in vitro chemotaxis assay. Moreover, JHMV infection of CXCR2−/− mice resulted in an approximate 60% reduction of PMN migration into the CNS, yet these mice survived infection and controlled viral replication within the brain. Treatment of JHMV-infected CXCR2−/− mice with anti-CXCR2 antibody did not modulate PMN migration nor alter viral clearance or mortality, indicating the existence of compensatory mechanisms that facilitate sufficient migration of PMNs into the CNS in the absence of CXCR2. Collectively, these findings highlight a previously unappreciated role for ELR-positive chemokines in enhancing host defense during acute viral infections of the CNS