Role of Satvavajaya Chikitsa in Grahani Roga with special reference to Irritable Bowel Syndrome

According to Charaka Samhita, the Chikitsa is divided into three. Daivavyapashraya, Yuktivyapashraya and Satvavajaya. Here Satvavajaya represents uplifting the Satva Guna of Manas, which helps to overcome the psychological illness a person is going through. Even though Grahani Roga is not a Manasika Vyadhi the results are proving that Satvavajaya Chikitsa is needed in Sharirika Vyadis too. Grahani Roga can be correlated to irritable bowel syndrome (IBS) where the psychological state of an individual plays a major role in prognosis of treatment. By approaching pharmacological treatment alone the individual may not recover fully and chances of reoccurrence is very high. Since Ayurveda treats the Rogi as a whole entity the mental state of a person is taken into consider before treatment. Population based studies estimate the prevalence of irritable bowel syndrome is 10-20% per year. Considering the increasing rate gastrointestinal disease across the world treatment approach through Ayurveda is need of the time

The Analysis of the Impact of Yoga on Healthcare and Conventional Strategies for Human Pose Recognition

Human pose estimation is a profound, established computer vision issue that has uncovered numerous past difficulties. Breaking down human exercise is advantageous in multiple fields like surveillance, biometrics, and many healthcare applications. Workout with yoga poses is famous these days since yoga activities can expand adaptability and muscular quality, and the respiration procedure will be improvised. The yoga postures evaluation is hard to check, so specialists will most likely be unable to benefit from the exercises ultimately. IoT-based yoga frameworks are required for individuals who need to rehearse Yoga at home. A few studies are recommended camera-oriented or wearable gadget-oriented yoga posture finding strategies with more precision. Nonetheless, camera-based plans have security and privacy issues, and the wearable device-based methods are illogical in the earlier applications. To build such systems, one must have a strong foundation and current research in pose estimation. In this paper, first, the impact of Yoga on humans with various stress levels is analysed on the real-time data. Second, the comprehensive review of yoga posture recognition systems from machine learning to deep learning strategies and evaluation metrics discusse

A study on standardization of Bindu Pramana in Nasya Karma

Panchakarma is a unique system of medicine comprising of five specialised purificatory procedures, the action of which is fruitful only if it is administered by giving due importance to Matra and Kala. Matra, the concept of dose fixation is of utmost importance in the practice of Panchakarma in order to get optimum therapeutic effect. Nasya Karma occupies a special place in the domain of Panchakarma as it deals with the organ of high importance, the “Shiras”. In the Classics, there is description regarding Bindu Pramana for the administration of Nasya Karma which varies from individual to individual as it is to be measured for each and every individual by dipping the first two phalanges of index finger in Sneha Dravya. But, the current practice of Nasya Karma is done by administering Nasya Dravya in the form of drops rather than adopting the concept of Bindu Pramana. In this regard, an observational study was conducted on 30 subjects as an attempt to standardize the concept of Bindu Pramana and the results were documented in relation to age, gender, height, weight, BMI, circumference and height of middle and distal phalanx of index finger

An Observational study to evaluate the effect of Vaitarana Basti in the management of Vatakaphaja Gridhrasi vis-à-vis Sciatica

Sciatica refers to the low back pain radiating to lower limb in a dermatomal distribution. Sciatica is a common cause of pain and disability; it is more persistent and severe than low back pain. Sciatica prevalence from different studies ranged from 1.2% to 43%. Physical activity at work and occupational workload, such as lifting, work related twisting of the trunk, occupational exposure to whole body vibration for example machine operators, motor vehicle drivers have also been suggested to be risk factors for Sciatica. Obesity has previously been linked to Sciatica. All these factors create pressure on spinal cord producing low back ache and radiating pain. Signs and Symptoms of Sciatica shows close resemblance with Gridhrasi. In Ayurveda, Acharya Vangasena has mentioned Vaitarana Basti in the management of Gridhrasi. Vaitarana Basti adopted here in this study has a direct reference for Gridhrasi in Vangasena samhita and Acharya Chakradutta while mentioning Vaitarana Basti has indicated it in Shula, Vatakaphaja vikaras. Considering the ingredients, it is a Shodhana, Teekshna type of Basti which is beneficial in Vatakaphaja Gridhrasi. A minimum of 20 subjects who fulfilled the diagnostic and inclusion criteria were subjected to the intervention. The overall results in the study revealed statistically highly significant result

A Constraint Programming and Hybrid Approach to Nurse Rostering Problems

This paper describes a decision support methodologies for nurse rostering problem in a modern hospital environment. In particular, it is very important to efficiently utilise time and effort, to evenly balance the workload among people and to attempt to satisfy personnel preference. We presented a complete model to formulate all the complex real-world constraints, solution approach and Hybrid approaches to nurse rostering problem. DOI: 10.17762/ijritcc2321-8169.15037

A perspective approach on Energy efficiency and Cloud Faster of mobile in cloud computing

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IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection.

Type 2 immune responses are essential in protection against intestinal helminth infections. In this study we show that IL-22, a cytokine important in defence against bacterial infections in the intestinal tract, is also a critical mediator of anti-helminth immunity. After infection with Nippostrongylus brasiliensis, a rodent hookworm, IL-22-deficient mice showed impaired worm expulsion despite normal levels of type 2 cytokine production. The impaired worm expulsion correlated with reduced goblet cell hyperplasia and reduced expression of goblet cell markers. We further confirmed our findings in a second nematode model, the murine whipworm Trichuris muris. T.muris infected IL-22-deficient mice had a similar phenotype to that seen in N.brasiliensis infection, with impaired worm expulsion and reduced goblet cell hyperplasia. Ex vivo and in vitro analysis demonstrated that IL-22 is able to directly induce the expression of several goblet cell markers, including mucins. Taken together, our findings reveal that IL-22 plays an important role in goblet cell activation, and thus, a key role in anti-helminth immunity

Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

<p>Abstract</p> <p>Background</p> <p>High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical questions. Statistical and computational methods are key for drawing meaningful and accurate conclusions from the massive and complex datasets generated by the sequencers. We provide a detailed evaluation of statistical methods for normalization and differential expression (DE) analysis of Illumina transcriptome sequencing (mRNA-Seq) data.</p> <p>Results</p> <p>We compare statistical methods for detecting genes that are significantly DE between two types of biological samples and find that there are substantial differences in how the test statistics handle low-count genes. We evaluate how DE results are affected by features of the sequencing platform, such as, varying gene lengths, base-calling calibration method (with and without phi X control lane), and flow-cell/library preparation effects. We investigate the impact of the read count normalization method on DE results and show that the standard approach of scaling by total lane counts (e.g., RPKM) can bias estimates of DE. We propose more general quantile-based normalization procedures and demonstrate an improvement in DE detection.</p> <p>Conclusions</p> <p>Our results have significant practical and methodological implications for the design and analysis of mRNA-Seq experiments. They highlight the importance of appropriate statistical methods for normalization and DE inference, to account for features of the sequencing platform that could impact the accuracy of results. They also reveal the need for further research in the development of statistical and computational methods for mRNA-Seq.</p

High-Throughput SuperSAGE for Digital Gene Expression Analysis of Multiple Samples Using Next Generation Sequencing

We established a protocol of the SuperSAGE technology combined with next-generation sequencing, coined “High-Throughput (HT-) SuperSAGE”. SuperSAGE is a method of digital gene expression profiling that allows isolation of 26-bp tag fragments from expressed transcripts. In the present protocol, index (barcode) sequences are employed to discriminate tags from different samples. Such barcodes allow researchers to analyze digital tags from transcriptomes of many samples in a single sequencing run by simply pooling the libraries. Here, we demonstrated that HT-SuperSAGE provided highly sensitive, reproducible and accurate digital gene expression data. By increasing throughput for analysis in HT-SuperSAGE, various applications are foreseen and several examples are provided in the present study, including analyses of laser-microdissected cells, biological replicates and tag extraction using different anchoring enzymes