12 research outputs found
Risk prediction to inform surveillance of chronic kidney disease in the US Healthcare Safety Net: a cohort study
Deformation behaviour of two phase materials: Cu-Al system
A study has been made of the deformation behaviour of a series of dual phase (? + ??) and ? + eutectoid Cu-Al alloys. The effect of martensite or eutectoid as the second phase on flow stress, work hardening, and total elongation is described. It is seen that the strengthening effect of martensite becomes greater than that of eutectoid at larger strains. Analysis of stress–strain curves shows that the strain hardening exponent n changes continuously with strain and, as such, the analysis based on the Ludwik equation (? = ?0 + k??pn?) is performed. It is found that alloys showing higher ductility exhibit a three stage behaviour. An explanation for this stage behaviour in terms of the deformation mechanisms involved is presente
Hepcidin-25 in Diabetic Chronic Kidney Disease Is Predictive for Mortality and Progression to End Stage Renal Disease
Survivability of hospitalized chronic kidney disease (CKD) patients with moderate to severe estimated glomerular filtration rate (eGFR) after experiencing adverse drug reactions (ADRs) in a public healthcare center: a retrospective 3 year study
A more accurate method acquirement by a comparison of the prediction equations for estimating glomerular filtration rate in Chinese patients with obstructive nephropathy
Variability in estimated glomerular filtration rate values is a risk factor in chronic kidney disease progression among patients with diabetes
Challenges and approaches for the development of safer immunomodulatory biologics
Immunomodulatory biologics are a class of agents that render their therapeutic effect via modulating or harnessing immune responses. Despite their therapeutic efficacy in complex conditions including cancer and autoimmune diseases, there is a growing concern about their unwanted adverse events including infections, malignancy, cytokine release syndromes, anaphylaxis, hypersensitivity and immunogenicity. In this article, we assess the safety issues associated with immunomodulatory biologics and discuss the key approaches to understand, predict and mitigate adverse events associated with their use