3 research outputs found
Incidence and progression of coronary artery calcium in HIV-infected and HIV-uninfected men
- Author
- Publication venue
- Publication date
- 23/04/2020
- Field of study
Objective: The aim of this article is to determine whether HIV-infected (HIVþ) men have either higher incidence or more rapid progression of coronary artery calcium (CAC) compared with HIV-uninfected (HIVÀ) controls. Design: Prospective observational study. Setting: Multicenter study in four US academic research centers: University of Pittsburgh, Johns Hopkins University, University of California Los Angeles, and Northwestern University. Participants: Eight hundred and twenty-five men (541 HIVþ and 284 HIVÀ) enrolled in the cardiovascular substudy of the Multicenter AIDS Cohort Study who underwent serial cardiac computed tomography (CT) imaging during a mean follow-up of 5 years (range, 2-8 years). Main outcome measures: Incidence and progression of CAC assessed by cardiac CT. Results: During follow-up, 21% of HIVþ men developed incident CAC compared with 16% of HIVÀ men. This association persisted after adjustment for traditional and HIVassociated risk factors: hazard ratio 1.64 (1.13-3.14). However, there was no association between HIV serostatus and CAC progression among men with CAC present at baseline. Current smoking and increased insulin resistance, both modifiable risk factors, were independently associated with increased incidence of CAC. No evidence supporting an elevated risk for either CAC progression or incidence was found for either dyslipidemia or long-term usage of antiretroviral therapy. Conclusion: In this large study of HIVþ and HIVÀ men who underwent serial cardiac CT scan imaging, HIVþ men were at significantly higher risk for development of CAC: hazard ratio 1.64 (1.13-3.14). In addition, two important and modifiable risk factors were identified for increased incidence of CAC. Taken together, these findings underscore the potential importance for smoking cessation and interventions to improve insulin resistance among HIVþ men
Antiseptics for treating infected wounds: Efficacy on biofilms and effect of pH
- Author
- Ahlstrom B
- Akiyama H
- Amalaradjou MAR
- Ames GF
- Apelqvist J
- Arzt H
- Badawy EI
- Bailey DM
- Balogh DM
- Barbour ME
- Basrani B
- Basrani B
- Baxter CR
- Benjamin A. Lipsky
- Bjarnsholt T
- Block SS
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- Brook I
- Brown ML
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- Butcher M
- Cabral CT
- Campbell N
- Chang Y
- Chang YC
- Claudia Vuotto
- Clegg MS
- Cookson BD
- Cooper RA
- Cutting KF
- Dai YY
- Danielsen L
- Daróczy J
- Davies GE
- Davis IJ
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- De Saint Jean M
- Denton GW
- Devine DA
- Eaglstein WH
- Fardal O
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- Foulkes DM
- Fumal I
- Gianfranco Donelli
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- Greenstein G
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- Kramer A
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- Kremer AN
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- Körber A
- Lacey RW
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- Larson EL
- Lavelle KJ
- Lawrence JC
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- Percival SL
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- Yager DR
- Zamora JL
- Zhou LH
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
A second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
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- Muñóz-Hernández LL
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- Mybaya H
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- Nikitas N
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- Obeidat M
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- Orlikowska I
- Ortega-Paino E
- Ortiz AB
- Osbourne W
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- Ostermann M
- Ostrowski M
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- Owen S
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- Wiliams A
- Wilkin F
- Wilkins J
- Wilkinson A
- Wilkinson B
- Williams A
- Williams A
- Williams C
- Williams D
- Williams E
- Williams E
- Williams G
- Williams H
- Williams J
- Williams K
- Williams M
- Williams P
- Williams S
- Williams T
- Willis C
- Willis H
- Wills M
- Willson J
- Wilson A
- Wilson DJ
- Wilson J
- Wilson JF
- Wiltfang J
- Winchester J
- Winkler TW
- Winmill H
- Winnard S
- Winter C
- Winter K
- Winter-Goodwin B
- Wittig M
- Witzke O
- Wolf-Roberts R
- Wolford BN
- Wong I
- Wong J
- Wong J
- Wood D
- Wood H
- Wood S
- Wood S
- Wood T
- Woodford C
- Woodruff M
- Woods L
- Woodward E
- Woodward J
- Woolcock M
- Woolley AE
- Worner R
- Worsley L
- Wray G
- Wren L
- Wreybrown C
- Wright C
- Wright DJ
- Wright J
- Wright M
- Wright S
- Wrobel N
- Wu Y
- Wulandari R
- Wylie K
- Wyllie DH
- Wynter I
- Xavier K
- Xue X
- Yagi K
- Yamada M
- Yamada Y
- Yamagata K
- Yamasaki M
- Yang J
- Yaspan B
- Yassen AM
- Yasui Y
- Yates B
- Yatomi M
- Ye C
- Yermakovich D
- Yeung RSM
- Yi X
- Yonekawa A
- Yoo S
- Yoon K
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Young M
- Yue F
- Yun N
- Yáñez CE
- Yáñez Z
- Zainulabid UA
- Zainy T
- Zak A
- Zaki A
- Zamikula J
- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
- Zholdybayeva E
- Zhou W
- Zhu W
- Zitter L
- Zoller H
- Zongo O
- Zorloni C
- Zuñiga-Pacheco P
- Zárate RN
- Zúñiga-Ramos J
- Álvarez BG
- Ávila-Arcos MA
- Ávila-Arcos MC
- Özer O
- Überla K
- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study