ANSI standards: creating a local, searchable database

Purpose – To review the history behind and steps taken to inventory and build search/edit modules for a database containing the Iowa State University Library\u27s extensive collection of American National Standards Institute (ANSI) standards. Design/methodology/approach – Iowa State University built a database inventory of the ANSI collection of standards through the use of Microsoft Excel and Oracle production software. The collection was inventoried and input into an Excel database, then converted into a web‐based search engine using Oracle software. Edit modules were developed to allow for adding to the database, and updating and correcting existing records. Findings – With the addition of this search engine and edit module, the task of keeping records up to date and keeping patrons informed as to the availability of standards within the ISU collection has been greatly improved. Practical implications – The implications for this form of database suggest it could be introduced into other major research libraries with large collections of uncatalogued literature utilizing similar software and expertise. This was a local concern that could have a broad impact on the way ANSI standards are inventoried and searched in libraries. Originality/value – The library that possesses a large collection of work under a single call number that is not inventoried and is looking for solutions for improved patron access will find this information valuable

PAR1 is selectively over expressed in high grade breast cancer patients: a cohort study

<p>Abstract</p> <p>Background</p> <p>The protease-activated receptor (PAR1) expression is correlated with the degree of invasiveness in cell lines. Nevertheless it has never been directed involved in breast cancer patients progression. The aim of this study was to determine whether PAR1 expression could be used as predictor of metastases and mortality.</p> <p>Methods</p> <p>In a cohort of patients with infiltrating ductal carcinoma studied longitudinally since 1996 and until 2007, PAR1 over-expression was assessed by immunoblotting, immunohistochemistry, and flow citometry. Chi-square and log rank tests were used to determine whether there was a statistical association between PAR1 overexpression and metastases, mortality, and survival. Multivariate analysis was performed including HER1, stage, ER and nodes status to evaluate PAR1 as an independent prognostic factor.</p> <p>Results</p> <p>Follow up was 95 months (range: 2–130 months). We assayed PAR1 in a cohort of patients composed of 136 patients; we found PAR1 expression assayed by immunoblotting was selectively associated with high grade patients (50 cases of the study cohort; P = 0.001). Twenty-nine of 50 (58%) patients overexpressed PAR1, and 23 of these (46%) developed metastases. HER1, stage, ER and PAR1 overexpression were robustly correlated (Cox regression, P = 0.002, P = 0.024 and P = 0.002 respectively). Twenty-one of the 50 patients (42%) expressed both receptors (PAR1 and HER1 P = 0.0004). We also found a statistically significant correlation between PAR1 overexpression and increased mortality (P = 0.0001) and development of metastases (P = 0.0009).</p> <p>Conclusion</p> <p>Our data suggest PAR1 overexpression may be involved in the development of metastases in breast cancer patient and is associated with undifferentiated cellular progression of the tumor. Further studies are needed to understand PAR1 mechanism of action and in a near future assay its potential use as risk factor for metastasis development in high grade breast cancer patients.</p