Latino Acculturative Stress Implications, Psychotherapeutic Processes, and Group Therapy

The Latino population is the fastest growing ethnic minority group in the United States. Yet, Latinos do not receive adequate mental health treatment due to the lack of cultural sensitivity regarding the necessity of bilingual and bicultural staff and culturally modified therapies. The difficulties associated with Latinos wrestling to preserve their native culture while also adjusting to the new dominant U.S. culture may cause them to experience acculturative stress. This specific distress may lead Latinos to implement maladaptive coping strategies that could influence Latino risk factors regarding unemployment, poverty, alcohol and drug abuse, aggressive behavior, mental health issues, and suicide rates. After reviewing the research focused on Latinos, Motivational Interviewing, Cognitive Behavioral Therapy, and Interpersonal Therapy were three major orientations aimed at individual therapy with Latinos while Cognitive Behavioral Group Therapy and psychoeducational groups dominated group therapy literature with Latinos. This review concluded the importance of incorporating cultural values and addressing socio-psychological stressors in therapy in order to produce significant treatment efficacy. Nonetheless, the rapidly increasing Latino population and genuine lack of cultural awareness requires continued research on culturally modifying other treatment modalities, multicultural competency for mental health professionals, and graduate program incorporation of a language component to stimulate interest with this needy population

Alien Registration- Doucette, Joseph W. (Baldwin, Cumberland County)

https://digitalmaine.com/alien_docs/32919/thumbnail.jp

CASPR: Judiciously Using the Cloud for Wide-Area Packet Recovery

We revisit a classic networking problem -- how to recover from lost packets in the best-effort Internet. We propose CASPR, a system that judiciously leverages the cloud to recover from lost or delayed packets. CASPR supplements and protects best-effort connections by sending a small number of coded packets along the highly reliable but expensive cloud paths. When receivers detect packet loss, they recover packets with the help of the nearby data center, not the sender, thus providing quick and reliable packet recovery for latency-sensitive applications. Using a prototype implementation and its deployment on the public cloud and the PlanetLab testbed, we quantify the benefits of CASPR in providing fast, cost effective packet recovery. Using controlled experiments, we also explore how these benefits translate into improvements up and down the network stack

Nucleus Accumbens Deep Brain Stimulation in a Rat Model of Binge Eating

Binge eating (BE) is a difficult-to-treat behavior with high relapse rates, thus complicating several disorders including obesity. In this study, we tested the effects of high-frequency deep brain stimulation (DBS) in a rodent model of BE. We hypothesized that BE rats receiving high-frequency DBS in the nucleus accumbens (NAc) core would have reduced binge sizes compared with sham stimulation in both a \u27chronic BE\u27 model as well as in a \u27relapse to chronic BE\u27 model. Male Sprague-Dawley rats (N=18) were implanted with stimulating electrodes in bilateral NAc core, and they received either active stimulation (N=12) or sham stimulation (N=6) for the initial chronic BE experiments. After testing in the chronic BE state, rats did not engage in binge sessions for 1 month, and then resumed binge sessions (relapse to chronic BE) with active or sham stimulation (N=5-7 per group). A significant effect of intervention group was observed on binge size in the chronic BE state, but no significant difference between intervention groups was observed in the relapse to chronic BE experiments. This research, making use of both a chronic BE model as well as a relapse to chronic BE model, provides data supporting the hypothesis that DBS of the NAc core can decrease BE. Further research will be needed to learn how to increase the effect size and decrease deep brain stimulation-treatment outcome variability across the continuum of BE behavior

CASPR: judiciously using the cloud for wide-area packet recovery

We revisit a classic networking problem -- how to recover from lost packets in the best-effort Internet. We propose CASPR, a system that judiciously leverages the cloud to recover from lost or delayed packets. CASPR supplements and protects best-effort connections by sending a small number of coded packets along the highly reliable but expensive cloud paths. When receivers detect packet loss, they recover packets with the help of the nearby data center, not the sender, thus providing quick and reliable packet recovery for latency-sensitive applications. Using a prototype implementation and its deployment on the public cloud and the PlanetLab testbed, we quantify the benefits of CASPR in providing fast, cost effective packet recovery. Using controlled experiments, we also explore how these benefits translate into improvements up and down the network stack.First author draf

Biological Transformation and Detoxification of 7,12-Dimethylbenzanthracene in Soil

Biological transformation and detoxification of 7,12-dimethylbenz(a)anathracene (DMBA) were studied in a nonacclimated sandy loam soil. Parent 14C DMBA biodegraded extensively (62% to 20%), accompanying an increase of metabolite 14C fraction (4% to 53%). Incorporation of DMBA into non extractable soil residue ,4C increased from 12 to 17%, but the increase was not statistically significant. DMBA was transformed into several metabolic products in the soil system, including 4-hydroxy-, 5-hydroxy-, and 10-hydroxy-DMBA and 7,12-dihydro 12-methyl-7-methylene-benz(a)anthracene-12-ol. High polarity transformation products of DMBA demonstrated a negative mu tagenic response with the Ames mutagenicity assay, strain TA 100, for both low and neutral pH soils. Moderate and low polar metabolites, however, induced mutagenicity for both soil samples. The mutagenicity of these metabolites decreased with incubation time in the soil, suggesting detoxification and assimilation of this polyaromatic hydrocarbon in soil systems. Mutagenic responses for the metabolites formed from low and neutral pH soil were similar. J. Water Pollut. Control Fed. 60, 1822 (1988)

Ten-year experience of more than 35,000 orofacial clefts in Africa

Abstract Background Surgical correction of orofacial clefts greatly mitigates negative outcomes. However, access to reconstructive surgery is limited in developing countries. The present study reviews epidemiological data from a single charitable organization, Smile Train, with a database of surgical cases from 33 African countries from 2001–2011. Methods Demographic and clinical patient data were collected from questionnaires completed by the participating surgeons. These data were recorded in Excel, analyzed using SPSS and compared with previously reported data. Results Questionnaires were completed for 36,384 patients by 389 African surgeons. The distribution of clefts was: 34.44% clefts of the lip (CL), 58.87% clefts of the lip and palate (CLP), and 6.69% clefts of the palate only (CP). The male to female ratio was 1.46:1, and the unilateral: bilateral ratio 2.93:1, with left-sided predominance 1.69:1. Associated anomalies were found in 4.18% of patients. The most frequent surgeries included primary lip/nose repairs, unilateral (68.36%) and bilateral (11.84%). There was seasonal variation in the frequency of oral cleft births with the highest in January and lowest by December. The average age at surgery was 9.34 years and increased in countries with lower gross domestic products. The average hospital stay was 4.5 days. The reported complication rate was 1.92%. Conclusions With the exception of cleft palates, results follow trends of worldwide epidemiologic reports of 25% CL, 50% CLP, and 25% CP, 2:1 unilateral:bilateral and left:right ratios, and male predominance. Fewer than expected patients, especially females, presented with isolated cleft palates, suggesting that limitations in economic resources and cultural aesthetics of the obvious lip deformity may outweigh functional concerns and access to treatment for females. A fewer than expected associated anomalies suggests either true ethnic variation, or that more severely-affected patients are not presenting for treatment. The epidemiology of orofacial clefting in Africa has been difficult to assess due to the diversity of the continent and the considerable variation among study designs. The large sample size of the data collected provides a basis for further study of the epidemiology of orofacial clefting in Africa.http://deepblue.lib.umich.edu/bitstream/2027.42/110688/1/12887_2015_Article_328.pd

Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts

Introduction: Cationic antimicrobial peptides (CAPs) defend against microbial pathogens; however, certain CAPs also exhibit anticancer activity. The purpose of this investigation was to determine the effect of the pleurocidin-family CAPs, NRC-03 and NRC-07, on breast cancer cells. Methods: MTT (3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide) and acid phosphatase cell-viability assays were used to assess NRC-03- and NRC-07-mediated killing of breast carcinoma cells. Erythrocyte lysis was determined with hemolysis assay. NRC-03 and NRC-07 binding to breast cancer cells and normal fibroblasts was assessed with fluorescence microscopy by using biotinylated-NRC-03 and -NRC-07. Lactate dehydrogenase-release assays and scanning electron microscopy were used to evaluate the effect of NRC-03 and NRC-07 on the cell membrane. Flow-cytometric analysis of 3,3'-dihexyloxacarbocyanine iodide- and dihydroethidium-stained breast cancer cells was used to evaluate the effects of NRC-03 and NRC-07 on mitochondrial membrane integrity and reactive oxygen species (ROS) production, respectively. Tumoricidal activity of NRC-03 and NRC-07 was evaluated in NOD SCID mice bearing breast cancer xenografts. Results: NRC-03 and NRC-07 killed breast cancer cells, including drug-resistant variants, and human mammary epithelial cells but showed little or no lysis of human dermal fibroblasts, umbilical vein endothelial cells, or erythrocytes. Sublethal doses of NRC-03 and, to a lesser extent, NRC-07 significantly reduced the median effective concentration (EC 50) of cisplatin for breast cancer cells. NRC-03 and NRC-07 bound to breast cancer cells but not fibroblasts, suggesting that killing required peptide binding to target cells. NRC-03- and NRC-07-mediated killing of breast cancer cells correlated with expression of several different anionic cell-surface molecules, suggesting that NRC-03 and NRC-07 bind to a variety of negatively-charged cell-surface molecules. NRC-03 and NRC-07 also caused significant and irreversible cell-membrane damage in breast cancer cells but not in fibroblasts. NRC-03- and NRC-07-mediated cell death involved, but did not require, mitochondrial membrane damage and ROS production. Importantly, intratumoral administration of NRC-03 and NRC-07 killed breast cancer cells grown as xenografts in NOD SCID mice. Conclusions: These findings warrant the development of stable and targeted forms of NRC-03 and/or NRC-07 that might be used alone or in combination with conventional chemotherapeutic drugs for the treatment of breast cancer.Peer reviewed: YesNRC publication: Ye