Immune dysfunction in patients with end-stage chronic renal failure

This literature review presents an immune system disorder in end-stage renal disease (ESRD), emphasizing the specific role of uremia and related changes. Finally, on the basis of new relationships between the changes in the immune system of ESRD patients, it emphasizes the potential role of the immune dysfunction as the main cause of the highmortality in this patient population and the need for further research in this area

RADICAL SINGLE-STAGE OPERATIONS AT INTESTINAL OBSTRUCTION, CAUSED BY THE TUMOR OF THE LEFT HALF PART OF THE LARGE INTESTINE (CURRENT STATUS OF THE PROBLEMS)

In more than 40% of cases, colon cancer (CС) is diagnosed in stages III-IV, at the same time the resectability reaches 70-80%. The main priority of surgical intervention by obturation of intestinal obstruction at the first stage is the bowel emptying from the contents and the elimination of its obstruction. Intraoperative entero- and colon lavage with subsequent colosorption facilitate single-stage surgical interventions. When treating patients with decompensated intestinal obstruction, preference is given to more sparing and multi-stage surgical interventions. The key point of the operation is the removal of the tumor in full volume R0. Segmental left-sided colectomy can be performed in the presence of adequate edges of R0, as well as the conduct of lymphadenectomy. In the case of the presence of a locally advanced process involving neighboring organs, it is possible to perform a so-called «curative resection», an «an block» resection with complete or partial removal of the involved organs together with the tumor. In patients with compensated and subcompensated intestinal obstruction, it is possible to perform intestinal resection with the formation of a primary anastomosis. In recent years, endosurgical techniques for restoring the passage of intestinal contents, which can be considered as a method of preparing the patient for radical treatment, have become very popular in the treatment of patients with tumour obstruction. The possibility of open treatment of patients suffering from CC largely depends on the presence or absence of metastases in the liver. If their presence, in some cases, it is possible to perform anatomical resections of the affected areas of the liver. Early postoperative results of surgical treatment of patients after removal of large intestine tumours largely depend on the full preparation of the intestine, the presence of concomitant diseases, as well as the ways of protection of the anastomosis and its type

The Eurasian heartland: a continental perspective on Y-chromosome diversity.

The nonrecombining portion of the human Y chromosome has proven to be a valuable tool for the study of population history. The maintenance of extended haplotypes characteristic of particular geographic regions, despite extensive admixture, allows complex demographic events to be deconstructed. In this study we report the frequencies of 23 Y-chromosome biallelic polymorphism haplotypes in 1,935 men from 49 Eurasian populations, with a particular focus on Central Asia. These haplotypes reveal traces of historical migrations, and provide an insight into the earliest patterns of settlement of anatomically modern humans on the Eurasian continent. Central Asia is revealed to be an important reservoir of genetic diversity, and the source of at least three major waves of migration leading into Europe, the Americas, and India. The genetic results are interpreted in the context of Eurasian linguistic patterns

The Eurasian Heartland: A continental perspective on Y-chromosome diversity

The nonrecombining portion of the human Y chromosome has proven to be a valuable tool for the study of population history. The maintenance of extended haplotypes characteristic of particular geographic regions, despite extensive admixture, allows complex demographic events to be deconstructed. In this study we report the frequencies of 23 Y-chromosome biallelic polymorphism haplotypes in 1,935 men from 49 Eurasian populations, with a particular focus on Central Asia. These haplotypes reveal traces of historical migrations, and provide an insight into the earliest patterns of settlement of anatomically modern humans on the Eurasian continent. Central Asia is revealed to be an important reservoir of genetic diversity, and the source of at least three major waves of migration leading into Europe, the Americas, and India. The genetic results are interpreted in the context of Eurasian linguistic patterns