Polyethyleneiminomethyl phosphonic acid (PEI-MP) radiolabeled with technetium-99m as a potential new radiopharmaceutical for diagnosis of bladder cancer

Introduction: The polymer PEI-MP (polyethyleneiminomethyl phosphonic acid) might be labelled with 99mTc. It was initially synthesized for palliative therapy of bone metastases after convenient radiolabelling, however in biodistribution studies performed with different PEI-MP/radionuclides, was obvious that the bladder wall was a target organ [1-3], demonstrating a certain selectivity to bladder cells, and so, to bladder cancer cells. The aim of this study was to evaluate the efficacy of 99mTc-PEI-MP for diagnosis of bladder carcinoma, evaluating in vitro and in vivo the biokinetics and biodistribution of 99mTc-PEI-M

A New Possible Approach for Therapy and Follow Up of Bladder Cancer

Introduction: The polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labelled with 188Re and 99mTc, have a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its follow up

The potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma

Introduction: The water-soluble polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re and 99mTc presents a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate in vivo the potential of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its diagnosis and follow u

An in vivo study to analyse the potential of 188Re-PEI-MP for metabolic radiotherapy of osteosarcoma and bladder carcinoma

Introduction: 188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re are recent approaches, with a strong potential for metabolic radiotherapy

Evaluation of the potential of 99mTc-PEI-MP for diagnosis and follow-up, in a comparative study using in vivo models of bladder cancer and osteosarcoma

Introduction: The aim of this study was to evaluate in vivo the efficacy of 99mTc-PEI- MP (polyethyleneiminomethyl phosphonic acid) for diagnosis of bladder cancer and osteosarcom

188Re-PEI-MP as potential agent for metabolic radiotherapy

Introduction: 188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of watersoluble bone-seeking polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate-groups) that might be labeled with 188Re are recent approaches, with a strong potential for bone cancer treatment. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP, as therapeutic agent for osteosarcoma, through in vitro and in vivo models

Análise do Potencial do 188Re-PEI-MP como Agente para Radioterapia Metabólica na Terapia de Osteossarcoma

Introdução e Objectivos: O desenvolvimento do polímero PEI-MP (polietilenoimina funcionalizada com grupos metilfosfonato), possível de radiomarcar com o 188Re (emissor de partículas beta de alta energia), parece poder ter um forte potencial para o tratamento de osteossarcoma. O objectivo deste estudo residiu na avaliação da eficácia do 188Re-PEI-MP como agente terapêutico para o tratamento de osteossarcoma

O potencial do 188Re-PEI-MP para a radioterapia metabólica de osteossarcoma e carcinoma da bexiga

Introdução e Objectivos: O polímero PEI-MP, polietilenoimina funcionalizada com grupos metilfosfonato, marcado com o 188Re tem um forte potencial para a radioterapia metabólica. Este estudo teve por objectivo avaliar a eficácia do 188Re-PEI-MP como agente terapêutico para osteossarcoma e carcinoma da bexiga

Radiolabeled polyethyleneiminomethyl phosphonic acid as a molecule with potential for diagnosis and therapy. Comparative study on models of bladder cancer and osteossarcoma.

Introduction: The polymer PEI-MP (polyethyleneiminomethyl phosphonic acid) that might be labeled with 99mTc and 188Re, have a strong potential for diagnosis and metabolic radiotherapy, respectively. The aim of this study was to evaluate the efficacy of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP as therapeutic agent, in a comparative study using in vitro and in vivo models of bladder cancer and osteossarcom