HEPATOPROTECTIVE EFFECT OF PHYLLANTHUS NIRURI ALKALOID FRACTION IN D–GALACTOSAMINE INDUCED HEPATITIS IN RATS

Objective: The current study was designed to explore the hepatoprotective activity of Phyllanthus niruri (PN) alkaloid fraction in induced hepatitis in rats.Methods: The rats are divided into 5 groups as per the experimental design. Pre alkaloid treatment of PN was given to the hepatitis rats for 21 d. After completion of the treatment, the serum was collected, and biochemical analysis was carried out. The hepatic markers like alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities, bilirubin (BL) urea (UR), creatinine (CR) levels are estimated in serum.Results: ALT, AST activities, BL, CR levels are increased, and UR levels are decreased in hepatitis rats. However with PN alkaloid fraction pre-treatment all these hepatic markers significantly (P<0.01) came back to near normal levels. Histopathological studies also prove that PN protected the hepatic tissue from hepatitis.Conclusion: The outcome of the present study showed that the alkaloid fraction of PN possesses hepatoprotective effect in hepatitis rats.Keywords: Phyllanthus niruri, Hepatitis, Liver marker