New reproductive and genetic technologies in Canada : towards a policy that manages technology and reproductive rights

New reproductive and genetic technologies in Canada, the void of regulation and policy, and the federal government's policy making attempts, to date, are the focus of this paper. The unencumbered growth of new reproductive and genetic technologies (NRGTs) are influenced by a technological imperative and our society's increasing reliance on the notion of reproductive rights. The unfettered use of the NRGTs may proffer a dystopian and eugenic future to society and to those affected, personally and financially, by the use of the technologies. Various stakeholders, including feminist organizations, the medical and scientific communities, and social policy advocates have been concerned with the lack of policy in the field, for well over ten years. To address the issue of NRGTs, the Canadian government established a Royal Commission (which reported in 1993), and has begun to institute a three part policy process that includes a voluntary moratorium on some of the morally and ethically controversial practices, the proposed prohibitive measures of Bill C-47, and a proposed regulatory framework. Throughout the policy development process the Canadian public and stakeholders, including those who have an interest in the future use of these technologies, have been consulted. Ten years into process, a synthesis of common views amongst previously divergent stakeholder groups now seems to be emerging. This paper reviews, analyses and examines the major issues of technological determinism and reproductive rights pertinent to the issue, in an effort to determine their effect on the development of the federal policy regarding new reproductive and genetic technologies

Preserving Innocence: Ending Perceived Adultification and Toxic Masculinity Toward Black Boys

As early as the age of ten, Black boys are viewed as older, guilty until proven innocent by law enforcement (including school resource officers), and encounter a myriad of adverse racialized academic and social experiences (e.g., explicit and implicit biases) (Goff et al., 2014; Noguera, 2008). Dancy (2014) noted how Trayvon Martin, a Black male teen murdered for essentially being seen as threatening and intimidating, was viewed as adult-aged, deviant, troubled, and shiftless. Moreover, Black boys are expected to express minimum “signs” of weakness, vulnerability, and/or sensitivity. The aforementioned social persona may contribute to young Black men and boys not feeling comfortable talking about their feelings and emotional distresses or even seeking professional help, when needed. Generally speaking, many young Black men and boys struggle with emotional vulnerability and choose to avoid or resist any attempts to examine their emotional experiences. Thus, it is important to note that the absence of healthy emotional support channels to process and disclose their feelings may lead to negative life outcomes, such as depression, cardiac arrest, and a shorter lifespan (Ford, 2020). In this article, we discuss the historical and contemporary contexts of adultification of young Black boys; present two vignettes to show examples of how boys are adultified; examine how toxic masculinity may prevent healthy relationships and emotional expressions for Black boys; and offer specific recommendations to educators and families

From a Bag Lunch to a Buffet: A Case Study of a Low-Income African American Academy’s Vision of Promoting College and Career Readiness in the United States

The purpose of this research study was to examine the ways in which stakeholders at a low-income, predominantly African American STEAM academy implement initiatives that support the college and career readiness of their students. We found that a shift in leadership efforts to ensure that academy students were prepared to be both college and career ready provided equity and access to a quality and individualized curriculum through the implementation of career academies. As a result, stakeholders believed that students were more included, valued, and engaged in the school

Culturally Responsive Postsecondary Readiness Practices for Black Males: Practice and Policy Recommendations for School Counselors

Postsecondary readiness is critical to broadening opportunities for educational and career options beyond high school. However, Black males are often at a disadvantage to gaining access to postsecondary preparation and school counselors who can respond to their academic needs. Therefore, the purpose of this study was to explore the experiences and culturally responsive practices of school stakeholders (who are predominantly Black) from an academy of engineering (career academy). The authors used a case study approach to examine culturally responsive practices school personnel utilize to enhance the college and career readiness of Black males. Findings emphasize the role of culturally responsive practices (e.g., Black male role models from business and industry in the engineering field and school counselors), cultural matching, and the role of the advisory board in ensuring the success of Black male students. Recommendations for practice, policy, and research for Black males and school counselors are discussed

Retention of African Americans in Gifted Education: Lessons Learned from Higher Education

Predominately White institutions of higher education have focused a considerable amount of attention on the underrepresentation of African American and other ethnically diverse students in colleges and universities. To address this problem, colleges and universities have focused not just on recruitment but also on the retention of African American students in these predominately White institutions. They have recognized that efforts to address underrepresentation cannot be limited to recruitment efforts; they must also consider factors associated with retention in the underrepresentation equation. We contend that gifted education embodies many of the same attributes, challenges, and barriers that predominately White colleges and universities possess for African American students. We recognize that, in public school systems, educators—teachers, school counselors, and administrators—have made much progress in recruiting culturally diverse populations in gifted programs. Despite the efforts, too many African American students are not being retained in gifted education programs. Using Sedlacek’s non- cognitive variables (1987, 1989, 1991, 1994, 1996, 1998), we examine the notion of retention and its many implications for gifted education. Thus, we offer, using these variables, recommendations for improving the retention of African American students in gifted educatio

Differential stability of expression of similarly specified endogenous and exogenous genes in the sea urchin embryo

The object of these experiments was to determine whether competitive titration in vivo of factors required for expression of the CyIIIa·CAT fusion gene would affect expression of the endogenous CyIIIa gene in the same embryos. Earlier work showed that expression of this fusion gene after injection into sea urchin eggs is stoichiometrically reduced when low molar excesses of DNA fragments containing only its regulatory domain are coinjected. In order to compare endogenous (i.e. CyIIIa) and exogenous (i.e. CyIIIa·CAT) expression simultaneously in embryos bearing excess competitor regulatory DNA, we developed, and here describe, a new procedure for generating transgenic sea urchin embryos in which all of the cells in many embryos, and most in others, bear the exogenous DNA. Such large reduction of mosaicism can be achieved by multiple injection of the exogenous DNA fragments into fertilized eggs. Using this method, we demonstrate that at a level of competitor DNA incorporation which reduces CyIIIa·CAT expression by 85%, endogenous CyIIIa mRNA levels are wholly unaffected. Nor is spatial expression of the endogenous CyIIIa gene disturbed. Since the CyIIIa·CAT genes are properly expressed under control of the CyIIIa regulatory sequences, they must participate in the same set of necessary DNA-protein interactions. However, we infer from the results that we report here that the regulatory complexes in the endogenous CyIIIa gene are greatly stabilized relative to those of the exogenous CyIIIa·CAT genes

Magnify is a universal molecular anchoring strategy for expansion microscopy

Expansion microscopy enables nanoimaging with conventional microscopes by physically and isotropically magnifying preserved biological specimens embedded in a crosslinked water-swellable hydrogel. Current expansion microscopy protocols require prior treatment with reactive anchoring chemicals to link specific labels and biomolecule classes to the gel. We describe a strategy called Magnify, which uses a mechanically sturdy gel that retains nucleic acids, proteins and lipids without the need for a separate anchoring step. Magnify expands biological specimens up to 11 times and facilitates imaging of cells and tissues with effectively around 25-nm resolution using a diffraction-limited objective lens of about 280 nm on conventional optical microscopes or with around 15 nm effective resolution if combined with super-resolution optical fluctuation imaging. We demonstrate Magnify on a broad range of biological specimens, providing insight into nanoscopic subcellular structures, including synaptic proteins from mouse brain, podocyte foot processes in formalin-fixed paraffin-embedded human kidney and defects in cilia and basal bodies in drug-treated human lung organoids

Statistical Learning Methods to Identify Nonwear Periods From Accelerometer Data

Background: Accelerometers are used to objectively measure movement in free-living individuals. Distinguishing nonwear from sleep and sedentary behavior is important to derive accurate measures of physical activity, sedentary behavior, and sleep. We applied statistical learning approaches to examine their promise in detecting nonwear time and compared the results with commonly used wear time (WT) algorithms. Methods: Fifteen children, aged 4–17, wore an ActiGraph wGT3X- BT monitor on their hip during overnight polysomnography. We applied Hidden Markov Models (HMM) and Gaussian Mixture Models (GMM) to classify states of nonwear and wear in triaxial acceleration data. Performance of methods was compared with WT algorithms across two conditions with differing amounts of consecutive nonwear. Clinical scoring of polysomnography served as the gold standard. Results: When the length of nonwear was less than or equal to WT algorithms’ predefined thresholds for consecutive nonwear time, GMM methods yielded improved classification error, specificity, positive predictive value, and negative predictive value over commonly used algorithms. HMM was superior to one algorithm for sensitivity and negative predictive value. When the length of nonwear was longer, results were mixed, with the commonly used algorithms performing better on some parameters but GMM with the greatest specificity. However, all approached the upper limits of performance for almost all metrics. Conclusions: GMM and HMM demonstrated robust, consistently strong performance across multiple conditions, surpassing or remaining competitive with commonly used WT algorithms which had marked inaccuracy when nonwear time periods were shorter. Of the two statistical learning algorithms, GMM was superior to HMM