Experimental and theoretical investigations of Erbium complex: DNA/BSA interaction, anticancer and antibacterial studies

To assess the biological potential of an Er complex that contains a 2,2'-bipyridine ligand, various techniques such as multispectral and molecular modeling procedures were utilized to examine its DNA-binding ability, BSA binding affinity, antimicrobial effects, and anticancer properties. By analyzing fluorescent information and employing the vant’ Hoff equation, important parameters such as the innate docking coefficient (Kb), Stern-Volmer coefficient (KSV), and thermodynamic properties including modifications in liberated energy (ΔG°), enthalpy (∆H°), and entropy (∆S°) were determined. The trial findings suggest that the compound can bind to DNA, primarily through groove binding. Additionally, the engagement between the Er compound and the protein BSA was examined using emission spectroscopy technique, revealing a powerful binding affinity between the compound and BSA. The Er complex binds to BSA primarily via hydrogen links and van der Waals forces, as indicated by the adverse values of ΔH° and ∆S°. Through a static quenching process, the complex significantly reduces the intrinsic fluorescence of BSA. Molecular binding calculations and rivalrous binding trials confirm that this compound dock to hydrophobic remains found in site III of BSA. Additionally, the Er complex demonstrates promising results in terms of its anticancer and antimicrobial activities based on screening tests

Wound Healing and Antimicrobial Activity of Cinnamomum Extract

Plant extract exhibited unique therapeutic characteristics due to their high content of chemical formulas with multiple medical effects. The plant extracts have shown a great advancement in controlling cardiovascular and metabolic disorders, as well as, it was used as antibacterial, antifungal, anti-cancer, and anti-inflammatory agents. Cinnamomum has been used a medical herbs from ancient times along with its uses as spice in food. Cinnamomum oild and extract have shown a great perspective in many areas of human health. We have aimed to prepare an ethanolic extract from dry cinnamomum powder, and investigate its influence in vitro against four types of bacteria and one fungal strain, and again in vivo as wound healing agent in rats. The results have shown that cinnamomum extract in ethanol was exhibited good effect in growth inhibition of escherichia coli, klebsiella sp, Staphylococcus epidermidis and Staphylococcus aureus, as well as Candida albicans. The greatest effect of cinnamomum extract was obtained against the Gram positive bacterial strains S. epidermidis and S. aureus. Furthermore, cinnamomum extract has shown to be a good wound healing agent, in which rats whom treated with cinnamomum extract have shown a faster healing compared to control rats starting from the day 7. These effects make cinnamomum to be very useful in the medical field generally, and in inflammation line specifically

Characterization of Peppermint Plant Extract and Antimicrobial Activity

The use of plant extracts in the medical and pharmacological fields have been increased in the last years. The plants have shown to possess materials with important features that can be used as a treatment in multiple health risks such as inflammation, cardiovascular disorders, bacteria and fungus. Peppermint was used extensively as medical herbs and have given a remarkable results. We aimed to prepare water and alcoholic (methanol) extract of peppermint leaves and characterize the presence of some phytochemical compounds qualitatively, along with some trace elements (copper, zinc and selenium). The antimicrobial activity of peppermint extract was investigated against two Gram negative escherichia coli as well as klebsiella sp, also two Gram positive bacterial strains Staphylococcus epidermidis as well as Staphylococcus aureus, as well as one fungi (Candida albicans). We have obtained the presence of flavonoids, polyphenolic compounds, steroids, carbohydrate, and protein contents in the extract of peppermint. Copper, zinc and selenium levels were detected in good amount in the extract. Furthermore, both water and methanol extract of peppermint have shown good antimicrobial activity against the experimented strains. Nevertheless, the extraction by methanol have shown more powerful activity than water against all strains