Congestion control using in-network telemetry for lossless datacenters

In the Ethernet lossless Data Center Networks (DCNs) deployed with Priority-based Flow Control (PFC), the head-of-line blocking problem is still difficult to prevent due to PFC triggering under burst traffic scenarios even with the existing congestion control solutions. To address the head-of-line blocking problem of PFC, we propose a new congestion control mechanism. The key point of Congestion Control Using In-Network Telemetry for Lossless Datacenters (ICC) is to use In-Network Telemetry (INT) technology to obtain comprehensive congestion information, which is then fed back to the sender to adjust the sending rate timely and accurately. It is possible to control congestion in time, converge to the target rate quickly, and maintain a near-zero queue length at the switch when using ICC. We conducted Network Simulator-3 (NS-3) simulation experiments to test the ICC’s performance. When compared to Congestion Control for Large-Scale RDMA Deployments (DCQCN), TIMELY: RTT-based Congestion Control for the Datacenter (TIMELY), and Re-architecting Congestion Management in Lossless Ethernet (PCN), ICC effectively reduces PFC pause messages and Flow Completion Time (FCT) by 47%, 56%, 34%, and 15.3×, 14.8×, and 11.2×, respectively

Characterization of the complete chloroplast genome of the Musk Larkspur Delphinium brunonianum (Ranunculales: Ranunculaceae)

Musk Larkspur (Delphinium brunonianum) is a perennial herb of the family Ranunculace with medicinal values. In this study, the chloroplast (cp) genome of this herb was determined to be 153,926 bp long with an A + T-biased base composition, and comprises a pair of inverted repeat (IR) regions (26,559 bp), separated by a large single-copy (LSC) region (84,512 bp) and a small single-copy (SSC) region (16,296 bp). A total of 112 gene species were annotated with 19 of them being completely or partially duplicated. Eighteen gene species harbor one or two introns. Phylogenetic analysis challenged the monophyly of the subfamily Ranunculoideae

Prenatal findings and molecular cytogenetic analyses of a de novo interstitial deletion of 1q23.3 encompassing PBX1 gene

Objectives: To present the prenatal findings and the molecular cytogenetic analyses of a de novo interstitial deletion of 1q23.3 encompassing PBX1 gene. Case report: A 32-year-old woman (gravida 1, para 0) underwent amniocentesis at 26 weeks' gestation because of constant small fetal kidneys on prenatal ultrasound. Chromosome microarray analysis (CMA) detected a de novo deletion of 1.871 Mb at 1q23.3. The deletion encompassed 2 genes of PBX1 and LMX1A. PBX1 haploinsufficiency had been reported to lead syndromic congenital anomalies of kidney and urinary tract (CAKUT) in humans. Furthermore, at 31 weeks’ gestation, borderline oligohydramnios and restricted fetal dimensions were revealed. Ultimately, the pregnancy was terminated at 32 weeks with a 1500-g female fetus presenting polydactyl of left hand. Conclusions: The shared phenotypes between this case and the previously published prenatal cases demonstrate that loss of function mutation in PBX1 should be suspicious in fetus with bilateral renal hypoplasia, oligohydramnios and intrauterine growth retardation (IUGR). Keywords: PBX1, Renal hypoplasia, Prenatal diagnosis, Chromosome microarray analysi

Prenatal diagnosis and early childhood outcome of fetuses with extremely large nuchal translucency

Abstract Objective To evaluate the prenatal and perinatal outcome of fetuses with extremely large nuchal translucency (eNT) thickness (≥ 6.5 mm). Methods 193 (0.61%) singleton fetuses with eNT were retrospectively included. Anomaly scan, echocardiography, and chromosomal and genetic test were included in our antenatal investigation. Postnatal follow-up was offered to all newborns. Results Major congenital anomalies included congenital heart defect (32.6%, 63/193), hydrops fetalis (13.5%, 26/193), omphalocele (9.3%, 18/193), and skeletal dysplasia (7.8%, 15/193) et al. Abnormal karyotype was identified in 81/115 (70.4%) cases including Turner syndrome (n = 47), Trisomy 18 (n = 17), Trisomy 21 (n = 9), and Trisomy 13 (n = 3). Chromosomal microarray analysis provided informative results with 3.6% (1/28) incremental diagnostic yield over conventional karyotyping. The diagnostic yield of exome sequencing is 10.0% (2/20). There was no significant increase [Odds Ratio (OR) = 1.974; 95% confidence interval 0.863–4.516; P = 0.104] in the incidence of chromosomal defects despite the presence of other structural anomalies. Only 13 fetuses were successfully followed up and survived at term, no one was found with developmental delay or mental retardation. Conclusions Extremely large NT has a high risk of chromosomal abnormality. CMA and ES improve chromosomal genomic and genetic diagnosis of fetal increased NT. When cytogenetic analysis and morphology assessment are both normal, the outcome is good

Structural insights into stereospecific reduction of α, β-unsaturated carbonyl substrates by old yellow enzyme from <i>Gluconobacter oxydans</i>

<div><p>We report the crystal structure of old yellow enzyme (OYE) family protein Gox0502 (a.a 1–315) in free form at 3.3 Å. Detailed structural analysis revealed the key residues involved in stereospecific determination of Gox0502, such as Trp66 and Trp100. Structure-based computational analysis suggested the bulky side chains of these tryptophan residues may play important roles in product stereoselectivity. The introduction of Ile or Phe or Tyr mutation significantly reduced the product diastereoselectivity. We hypothesized that less bulky side chains at these critical residues could create additional free space to accommodate intermediates with different conformations. Notably, the introduction of Phe mutation at residue Trp100 increased catalytic activity compared to wild-type Gox0502 toward a set of substrates tested, which suggests that a less bulky Phe side chain at residue W100F may facilitate product release. Therefore, Gox0502 structure could provide useful information to generate desirable OYEs suitable for biotechnological applications in industry.</p></div

Improvement of E Se tea extracts on renal mesangial cell apoptosis and high-fat-diet/streptozotocin-induced diabetic nephropathy

E Se tea, the leaves of Malus toringoides (Rehd.) Hughes, is a kind of traditional beverage, which is often used to relieve hyperglycemia and hyperlipidemia and other symptoms, while its effect on diabetic nephropathy (DN) is still unclear. In this study, we evaluated the improvement of the ethanol extract of M. toringoides (EMT) on tert-butyl hydroperoxide (t-BHP)-induced rat glomerular mesangial cells (HBZY-1) apoptosis and high-fat-diet (HFD)/streptozotocin (STZ)-induced DN rats. The results showed that the EMT significantly reversed apoptosis, mitochondrial depolarization and cysteinyl aspartate specific proteinase (caspase) 3/9 activation in t-BHP (50 μM)-exposed HBZY-1 cells. Moreover, 8-weeks treatment of EMT improved blood glucose, proteinuria, serum creatinine and urea nitrogen, renal oxidative stress, proinflammatory mediators, histopathology and decreased activation of caspase 3. These results suggested that the E Se tea may therefore be a potential complementary therapy targeting DN patients

The influence of post-production heat treatment on the multi-directional properties of nickel-aluminum bronze alloy fabricated using wire-arc additive manufacturing process

In this paper, a nickel-aluminum bronze alloy component is built using wire-arc additive manufacturing process. In order to investigate the influence of anisotropy introduced by the wire-arc additive manufacturing process, the layer-by-layer manufactured components with different post-production heat treatments are characterized by optical and scanning electron microscopy morphologies, X-ray diffraction and mechanical tests in longitudinal, transverse and normal directions. The experimental results show that the deposit exhibits higher strengths in the longitudinal and transverse direction than in the normal direction. Also, the ductility of the alloy is significantly improved with the designed quenching and tempering method, and competitive mechanical properties are achieved when tempering temperature reaches 650 °C. In addition, the anisotropy in the additively manufactured alloy can be effectively modified by the quenching and tempering heat treatments

Exciton-enabled meta-optics in two-dimensional transition metal dichalcogenides

Optical wavefront engineering has been rapidly developing in fundamentals from phase accumulation in the optical path to the electromagnetic resonances of confined nanomodes in optical metasurfaces. However, the amplitude modulation of light has limited approaches that usually originate from the ohmic loss and absorptive dissipation of materials. Here, an atomically thin photon-sieve platform made of MoS2 multilayers is demonstrated for high-quality optical nanodevices, assisted fundamentally by strong excitonic resonances at the band-nesting region of MoS2. The atomic thin MoS2 significantly facilitates high transmission of the sieved photons and high-fidelity nanofabrication. A proof-of-concept two-dimensional (2D) nanosieve hologram exhibits 10-fold enhanced efficiency compared with its non-2D counterparts. Furthermore, a supercritical 2D lens with its focal spot breaking diffraction limit is developed to exhibit experimentally far-field label-free aberrationless imaging with a resolution of ∼0.44λ at λ = 450 nm in air. This transition-metal-dichalcogenide (TMDC) photonic platform opens new opportunities toward future 2D meta-optics and nanophotonics.Agency for Science, Technology and Research (A*STAR)Ministry of Education (MOE)The work is financially supported by the Agency for Science, Technology and Research (A*STAR) Singapore under Grants 152700014 and 152700012. K.H. thanks CAS Pioneer Hundred Talents Program, “the Fundamental Research Funds for the Central Universities” in China, USTC Research Funds of the Double First-Class Initiative (Grant YD2030002003), the National Natural Science Foundation of China (Grant 61875181 and 61705085), and the support from the University of Science and Technology of China’s Centre for Micro and Nanoscale Research and Fabrication. G.Y., G.A., and C.S. acknowledge the support from the Agency for Science, Technology and Research (A*STAR) Singapore (Grant SERC A1685b0005) and Singapore Ministry of Education Academic Research Fund Tier 3 (MOE2016-T3- 1-006 (S)). H.S. acknowledges the support from the Singapore Ministry of Education through the Academic Research Fund under Project Tier 1-RG189/17(S). We thank Prof. Nikolay Zheludev for the valuable discussions. Z.W. thanks the support from Ms. Zhang Xin and Dr. Zhao Rui