Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014)

BackgroundThe Composite Dietary Antioxidant Index (CDAI), a composite score of multiple dietary antioxidants (including vitamin A, C, and E, selenium, zinc, and carotenoids), represents an individual’s comprehensive dietary antioxidant intake profile. CDAI was developed based on its combined effect on pro-inflammatory markers Tumor Necrosis Factor-α (TNF-α) and anti-inflammatory effects of Interleukin-1β (IL-1β), which are associated with many health outcomes, including depression, all-cause mortality, colorectal cancer, etc. Handgrip strength is used as a simple measure of muscle strength, not only is it highly correlated with overall muscle strength, but also serves as a diagnostic tool for many adverse health outcomes, including sarcopenia and frailty syndromes.PurposeThe association between CDAI and Handgrip strength (HGS) is currently unclear. This study investigated the association between CDAI (including its components) and HGS in 6,019 American adults.MethodThe research data were selected from the 2011–2014 National Health and Nutrition Survey (NHANES), and a total of 6,019 American adults were screened and included. A weighted generalized linear regression model was used to evaluate CDAI (including its components) and HGS.Results(1) CDAI was significantly positively correlated with HGS (β = 0.009, 0.005∼0.013, P < 0.001), and the trend test showed that compared with the lowest quartile of CDAI, the highest quartile of CDAI was positively correlated with HGS (β = 0.084, 0.042∼0.126, P = 0.002) and significant in trend test (P for trend < 0.0100). Gender subgroup analysis showed that male CDAI was significantly positively correlated with HGS (β = 0.015, 0.007∼0.023, P = 0.002), and the trend test showed that compared with the lowest quartile of CDAI, the highest quartile of CDAI was positively correlated with HGS (β = 0.131, 0.049∼0.213, P = 0.006) and the trend test was significant (P for trend < 0.0100). There was no correlation between female CDAI and HGS, and the trend test was not statistically significant (P > 0.05). (2) The intake of dietary vitamin E, Zinc and Selenium showed a significant positive correlation with HGS (β = 0.004, 0.002∼0.007, P = 0.006; β = 0.007, 0.004∼0.009, P < 0.001; β = 0.001, 0.001∼0.001, P < 0.001), vitamin A, vitamin C and carotenoid were significantly associated with HGS in the Crude Model, but this significant association disappeared in the complete model with the increase of control variables. Gender subgroup analysis showed that in model 3, male dietary intake levels of vitamin E, Zinc, and Selenium were significantly positively correlated with HGS (β = 0.005, 0.002∼0.009, P = 0.011; β = 0.007, 0.004∼0.011, P = 0.001; β = 0.001, 0.001∼0.001, P = 0.004), the rest of the indicators had no significant correlation with HGS. Among the female subjects, dietary zinc intake was significantly positively correlated with HGS (β = 0.005, 0.001∼0.008, P = 0.008), and there was no significant correlation between other indicators and HGS (P > 0.05).ConclusionThere was an association between the CDAI and HGS, but there was a gender difference, and there was an association between the CDAI and HGS in male, but the association was not significant in female. Intake of the dietary antioxidants vitamin E, selenium, and zinc was associated with HGS in male, but only zinc was associated with HGS among dietary antioxidants in female

No Association between Elevated 2-h Postprandial Blood Glucose Levels and Functional Outcomes of Small-Artery Occlusion in Patients with Diabetes

BackgroundThe association between 2-h postprandial blood glucose level (2hPBG) and functional outcomes in patients with small-artery occlusion (SAO) is poorly understood. We aimed to explore the relationship between 2hPBG levels and functional outcomes in SAO patients with diabetes.MethodsWe retrospectively analyzed 174 diabetic patients diagnosed with SAO, and 2hPBG values were classified into four groups according to quartiles (<8.90, 8.90 to <12.16, 12.16 to <15.14, and ≥15.14 mmol/L), or according to clinical glycemic recommendations for adults with diabetes (<10 and ≥10 mmol/L, respectively). The relationship between 2hPBG levels and modified Rankin Scale (mRS) scores was assessed using univariate and multivariate analyses.ResultsAmong all patients with SAO, there were 139 patients with favorable outcomes and 35 patients with poor outcomes. National Institutes of Health Stroke Scale scores were significantly different according to mRS scores (P < 0.001) in both the univariate and multivariate analyses. The binary logistic regression analyses showed that compared with the lowest quartile (<8.90 mmol/L), elevated 2hPBG levels (8.90 to <12.16, 12.16 to <15.14, and ≥15.14 mmol/L) were not associated with mRS scores after adjusting for multiple confounding factors. Compared with patients with 2hPBG levels <10 mmol/L, those with 2hPBG levels ≥10 mmol/L did not have a significant risk of poor outcome after adjusting for confounders. Meanwhile, the negative results appeared in the ordinal logistic regression of 2hPBG levels and 3-month functional outcomes.ConclusionElevated 2hPBG levels were not associated with unfavorable functional outcomes 3 months after stroke onset in SAO patients with diabetes

Fire Risk Assessment of Heritage Villages: A Case Study on Chengkan Village in China

Fire risk assessment is important in heritage-village risk management and cultural relics protection. This study aims to establish a fire risk assessment system and model to assess fire safety for heritage villages. Given the complexity and openness of the heritage village system, the nonlinearity of the driving factors, and the dual attributes of residence and tourism, this paper constructs an index system of three aspects: cultural relic value sensitivity, village fire hazard, and evacuation accessibility. Based on ANP and the Bayes algorithm, a hybrid intelligent model is developed, and the index is weighted by combining subjective expert scoring and objective fact statistics. Finally, ArcGIS buffer and network analysis functions are used for grid processing to quantify and evaluate the difference in fire risk distribution in spatial units of heritage villages. We apply this assessment method to Chengkan Village, a national critical cultural relic protection unit. The results reveal that the cluster settlement layout pattern of the ancestral temple buildings plays a decisive role in the fire risk distribution in Chengkan Village; furthermore, the main factors leading to fire risk were analyzed. In Chengkan Village’s core area, the focus of the local government should be on strengthening active fire prevention measures to reduce the probability of fire. In contrast, in the northern and southern areas, it should focus on enhancing passive fire prevention measures to reduce the possibility of significant fires

Improved Method of Defining Rainfall Intensity and Duration Thresholds for Shallow Landslides Based on TRIGRS

The Transient Rainfall Infiltration and Grid-Based Regional Slope-Stability (TRIGRS) model has been widely used to define rainfall thresholds for triggering shallow landslides. In this study, the rainfall intensity(I)-duration(D) thresholds for multiple slope units of an area in Pu’an County, Guizhou Province, China were defined based on TRIGRS. Given that TRIGRS is used to simulate the slope stability under the conditions of a given increasing sequence of I-D data, if the slope reaches instability at I = a, D = b, it will also become unstable in the case of I = a, D > b or I > a, D = b. To explore the effect of these I-D data with the same I or D values on the definition of I-D thresholds and the best method to exclude these data, two screening methods were used to exclude the I-D data that caused instability in the TRIGTS simulation. First, I-D data with the same I values when D values are greater than a certain limit value were excluded. Second, several D values were selected to exclude I-D data with the same I values for a slope unit. Then, an I value was selected to exclude I-D data with the same D values. After screening, two different I-D thresholds were defined. The comparison with the thresholds defined without screening shows that the I-D data with the same I or D values will reduce the accuracy of thresholds. Moreover, the second screening method can entirely exclude these data

Improved Method of Defining Rainfall Intensity and Duration Thresholds for Shallow Landslides Based on TRIGRS

The Transient Rainfall Infiltration and Grid-Based Regional Slope-Stability (TRIGRS) model has been widely used to define rainfall thresholds for triggering shallow landslides. In this study, the rainfall intensity(I)-duration(D) thresholds for multiple slope units of an area in Pu’an County, Guizhou Province, China were defined based on TRIGRS. Given that TRIGRS is used to simulate the slope stability under the conditions of a given increasing sequence of I-D data, if the slope reaches instability at I = a, D = b, it will also become unstable in the case of I = a, D > b or I > a, D = b. To explore the effect of these I-D data with the same I or D values on the definition of I-D thresholds and the best method to exclude these data, two screening methods were used to exclude the I-D data that caused instability in the TRIGTS simulation. First, I-D data with the same I values when D values are greater than a certain limit value were excluded. Second, several D values were selected to exclude I-D data with the same I values for a slope unit. Then, an I value was selected to exclude I-D data with the same D values. After screening, two different I-D thresholds were defined. The comparison with the thresholds defined without screening shows that the I-D data with the same I or D values will reduce the accuracy of thresholds. Moreover, the second screening method can entirely exclude these data

Association between Handgrip Strength and the Systemic Immune-Inflammation Index: A Nationwide Study, NHANES 2011–2014

(1) Background: The Systemic immune-inflammatory index (SII) has been proven to be an effective biomarker of human immune and inflammatory levels and has prognostic significance for most diseases. Handgrip strength (HGS) is a simple and low-cost strength measurement method, which is not only highly correlated with overall muscle strength but also accurately and reliably predicts the risk of multiple chronic diseases and mortality; (2) Purpose: Association between HGS and the SII is unclear. The purpose of this study was to investigate the association between HGS and the SII in American adults; (3) Methods: We used the data from the 2011–2012 and 2013–2014 cycles of the National Health and Nutrition Examination Survey (NHANES), involving a total of 8232 American adults (aged 18–80 years). The SII was calculated as the Platelet count × Neutrophil count/Lymphocyte count; HGS was recorded as the ratio of the sum of the highest grip-strength values of each hand to body mass index taken as the relative grip strength. A weighted generalized linear regression model and analysis of restricted cubic spline regression, adjusted for confounding factors, were used in this study to assess associations between HGS and the SII in American adults; (4) Results: There was a negative correlation between the HGS and the SII of different sexes (p < 0.05), and there was a significant negative nonlinear relationship between the HGS and the SII in males (p for nonlinear = 0.0035), and the SII showed a downward trend with the increase in the HGS in males (Q2: β = −61.03, p = 0.01; Q3: β = −61.28, p = 0.04, Q4: β = −64.36, p = 0.03, p for trend = 0.04), when the HGS exceeds 3.16, with the HGS increasing, the downward trend of increasing the SII slowed down. The nonlinear relationship between the HGS and the SII in females was not significant (p for nonlinear = 0.1011), and the SII showed a linear downward trend with the increase in the HGS (Q2: β = −24.91, p = 0.25; Q3: β = −62.01, p = 0.03, Q4: β = −74.94, p = 0.03, p for trend = 0.01); (5) Conclusions: HGS is inversely and independently associated with SII levels, and although the limited cubic spline regression analysis showed gender differences, the overall trend of the HGS and the SII in different genders was consistent, with both showing that the SII decreased with increasing the HGS. In addition, HGS has high general applicability based on its ease of measurement; it is possible to understand one’s own grip-strength level through routine grip-strength tests, and to make preliminary predictions on the current level of immunity and inflammation in the body

DoSDefender: A Kernel-Mode TCP DoS Prevention in Software-Defined Networking

The limited computation resource of the centralized controller and communication bandwidth between the control and data planes become the bottleneck in forwarding the packets in Software-Defined Networking (SDN). Denial of Service (DoS) attacks based on Transmission Control Protocol (TCP) can exhaust the resources of the control plane and overload the infrastructure of SDN networks. To mitigate TCP DoS attacks, DoSDefender is proposed as an efficient kernel-mode TCP DoS prevention framework in the data plane for SDN. It can prevent TCP DoS attacks from entering SDN by verifying the validity of the attempts to establish a TCP connection from the source, migrating the connection, and relaying the packets between the source and the destination in kernel space. DoSDefender conforms to the de facto standard SDN protocol, the OpenFlow policy, which requires no additional devices and no modifications in the control plane. Experimental results show that DoSDefender can effectively prevent TCP DoS attacks in low computing consumption while maintaining low connection delay and high packet forwarding throughput

Table_1_LncmiRHG-MIR100HG: A new budding star in cancer.docx

MIR100HG, also known as lncRNA mir-100-let-7a-2-mir-125b-1 cluster host gene, is a new and critical regulator in cancers in recent years. MIR100HG is dysregulated in various cancers and plays an oncogenic or tumor-suppressive role, which participates in many tumor cell biology processes and cancer-related pathways. The errant expression of MIR100HG has inspired people to investigate the function of MIR100HG and its diagnostic and therapeutic potential in cancers. Many studies have indicated that dysregulated expression of MIR100HG is markedly correlated with poor prognosis and clinicopathological features. In this review, we will highlight the characteristics and introduce the role of MIR100HG in different cancers, and summarize the molecular mechanism, pathways, chemoresistance, and current research progress of MIR100HG in cancers. Furthermore, some open questions in this rapidly advancing field are proposed. These updates clarify our understanding of MIR100HG in cancers, which may pave the way for the application of MIR100HG-targeting approaches in future cancer diagnosis, prognosis, and therapy.</p