B1gB_{\rm 1g} phonon anomaly driven by Fermi surface instability at intermediate temperature in YBa2_2Cu3_3O7−δ_{7-\delta}

We performed temperature- and doping-dependent high-resolution Raman spectroscopy experiments on YBa$_2$Cu$_3$O$_{7-\delta}$ to study $B$$_{\rm 1g}$ phonons. The temperature dependence of the real part of the phonon self-energy shows a distinct kink at $T=T_{\rm B1g}$ above $T$$_{\rm c}$ due to softening, in addition to the one due to the onset of the superconductivity. $T$$_{\rm B1g}$ is clearly different from the pseudogap temperature with a maximum in the underdoped region. The region between $T$$_{\rm B1g}$ and $T$$_{\rm c}$ resembles that of superconducting fluctuation or charge density wave order. While the true origin of the $B$$_{\rm 1g}$ phonon softening is not known, we can attribute it to a gap on the Fermi surface due to an electronic order. Our results may reveal the role of the $B$$_{\rm 1g}$ phonon not only in the superconducting state but also in the intertwined orders in multilayer copper oxide high-$T$$_{\rm c}$ superconductors.Comment: 5 pages, 4 figure

Tetraploid embryo aggregation produces high-quality blastocysts with an increased trophectoderm in pigs

Tetraploid complementation is an ideal method for demonstrating the differentiation potential of pluripotent stem cells. In this study, we selected the most efficient tetraploid production method for porcine embryos and investigated whether tetraploid blastomere aggregation could enhance the quality of tetraploid embryos. Three methods were investigated to produce tetraploid embryos: First, tetraploid embryos were produced using electro-fusion of two-cell stage parthenogenetic blastomere (FUTP). Second, somatic cell was injected into the mature oocyte and fused to produce tetraploid embryos. Third, oocytes were matured with Cytochalasin B (CB) for the late 22 h of in vitro maturation to inhibit the first polar body (PB1). Following that, non-PB1 oocytes were treated with CB for 4 h after parthenogenetic activation. There was no significant difference in the blastocyst development rate and tetraploid production rate of the embryos produced through the three methods. However, FUTP-derived blastocysts had a significantly lower percentage of apoptotic cells compared to other methods. The developmental competence of embryos, expression of trophectoderm cell marker genes, and distribution of YAP1 protein were investigated in tetraploid embryos produced using the FUTP method. The FUTP method most effectively prevented apoptosis during porcine tetraploid embryo formation. Tetraploid aggregation-derived blastocysts have a high proportion of trophectoderm with increased expression of the CDX2 mRNA and high YAP1 intensity. High-quality blastocysts derived from a tetraploid embryo aggregation can serve as suitable source material for testing the differentiation potential of pluripotent stem cells for blastocyst complementation in pigs

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As part of the next-generation Compact Advanced Satellite 500 (CAS500) project, CAS500-4 is scheduled to be launched in 2025 focusing on the remote sensing of agriculture and forestry. To obtain quantitative information on vegetation from satellite images, it is necessary to acquire surface reflectance through atmospheric correction. Thus, it is essential to develop an atmospheric correction method suitable for CAS500-4. Since the absorption and scattering characteristics in the atmosphere vary depending on the wavelength, it is needed to analyze the sensitivity of atmospheric correction parameters such as aerosol optical depth (AOD) and water vapor (WV) considering the wavelengths of CAS500-4. In addition, as CAS500-4 has only five channels (blue, green, red, red edge, and near-infrared), making it difficult to directly calculate key parameters for atmospheric correction, external parameter data should be used. Therefore, this study performed a sensitivity analysis of the key parameters (AOD, WV, and O3) using the simulated images based on Sentinel-2 satellite data, which has similar wavelength specifications to CAS500-4, and examined the possibility of using the products of GEOKOMPSAT-2A (GK2A) as atmospheric parameters. The sensitivity analysis showed that AOD was the most important parameter with greater sensitivity in visible channels than in the near-infrared region. In particular, since AOD change of 20% causes about a 100% error rate in the blue channel surface reflectance in forests, a highly reliable AOD is needed to obtain accurate surface reflectance. The atmospherically corrected surface reflectance based on the GK2A AOD and WV was compared with the Sentinel-2 L2A reflectance data through the separability index of the known land cover pixels. The result showed that two corrected surface reflectance had similar Seperability index (SI) values, the atmospheric corrected surface reflectance based on the GK2A AOD showed higher SI than the Sentinel-2 L2A reflectance data in short-wavelength channels. Thus, it is judged that the parameters provided by GK2A can be fully utilized for atmospheric correction of the CAS500-4. The research findings will provide a basis for atmospheric correction of the CAS500-4 in the future. ?? This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

Effects of Walking Promotion Using Smart Mobile Activity Meter on Changes in Metabolic Health

Background: Regular physical exercise can increase insulin sensitivity, improve good cholesterol levels, reduce body weight, and ameliorate cardiovascular risk factors. Over the past decade, e-health technologies using mobile applications were proven to be an effective delivery method for educational interventions. No e-health tools were designated specifically for patients with metabolic syndrome. Methods: Final analysis subjects were 7,234 as a result of excluding cases with missing values according to the variables used. We mediated the subjects to walk in advance, 3 months, and 6 months through smart mobile health care, and the level of improvement in the metabolic syndrome index was repeatedly measured. RM ANOVA & Path analysis & Sobel test was conducted to determine whether there was a mediating effect. Results: Subjects who practiced walking for up to 3 months tended to use smart mobile health care devices better for 6 months, and the walking practice rate increased. This confirmed that there was a significant partial mediating effect as a result of the Sobel test. after 6 months, WC and TG decrease. Conclusion: It was found that the more programs that provide advice and interventions on physical activity through smart mobile healthcare devices were used, the more helpful it was to promote walking exercise practice

Nodal fermions in a strongly spin-orbit coupled frustrated pyrochlore superconductor

The pyrochlore lattice, a three-dimensional network of corner-sharing tetrahedra, is a promising material playground for correlated topological phases arising from the interplay between spin-orbit coupling (SOC) and electron-electron interactions. Due to its geometrically frustrated lattice structure, exotic correlated states on the pyrochlore lattice have been extensively studied using various spin Hamiltonians in the localized limit. On the other hand, the topological properties of the electronic structure in the pyrochlore lattice have rarely been explored, due to the scarcity of pyrochlore materials in the itinerant paramagnetic limit. Here, we explore the topological electronic band structure of pyrochlore superconductor RbBi$_{2}$ using angle-resolved photoemission spectroscopy. Thanks to the strong SOC of the Bi pyrochlore network, we experimentally confirm the existence of three-dimensional (3D) massless Dirac fermions enforced by nonsymmorphic symmetry, as well as a 3D quadratic band crossing protected by cubic crystalline symmetry. Furthermore, we identify an additional 3D linear Dirac dispersion associated with band inversion protected by threefold rotation symmetry. These observations reveal the rich non-trivial band topology of itinerant pyrochlore lattice systems in the strong SOC regime. Through manipulation of electron correlations and SOC of the frustrated pyrochlore lattices, this material platform is a natural host for exotic phases of matter, including the fractionalized quantum spin Hall effect in the topological Mott insulator phase, as well as axion electrodynamics in the axion insulator phase.Comment: 18 pages, 4 figure

Sign-tunable anomalous Hall effect induced by two-dimensional symmetry-protected nodal structures in ferromagnetic perovskite oxide thin films

Magnetism and spin-orbit coupling (SOC) are two quintessential ingredients underlying novel topological transport phenomena in itinerant ferromagnets. When spin-polarized bands support nodal points/lines with band degeneracy that can be lifted by SOC, the nodal structures become a source of Berry curvature; this leads to a large anomalous Hall effect (AHE). Contrary to three-dimensional systems that naturally host nodal points/lines, two-dimensional (2D) systems can possess stable nodal structures only when proper crystalline symmetry exists. Here we show that 2D spin-polarized band structures of perovskite oxides generally support symmetry-protected nodal lines and points that govern both the sign and the magnitude of the AHE. To demonstrate this, we performed angle-resolved photoemission studies of ultrathin films of SrRuO$_3$, a representative metallic ferromagnet with SOC. We show that the sign-changing AHE upon variation in the film thickness, magnetization, and chemical potential can be well explained by theoretical models. Our study is the first to directly characterize the topological band structure of 2D spin-polarized bands and the corresponding AHE, which could facilitate new switchable devices based on ferromagnetic ultrathin films

Deep learning-based statistical noise reduction for multidimensional spectral data

In spectroscopic experiments, data acquisition in multi-dimensional phase space may require long acquisition time, owing to the large phase space volume to be covered. In such case, the limited time available for data acquisition can be a serious constraint for experiments in which multidimensional spectral data are acquired. Here, taking angle-resolved photoemission spectroscopy (ARPES) as an example, we demonstrate a denoising method that utilizes deep learning as an intelligent way to overcome the constraint. With readily available ARPES data and random generation of training data set, we successfully trained the denoising neural network without overfitting. The denoising neural network can remove the noise in the data while preserving its intrinsic information. We show that the denoising neural network allows us to perform similar level of second-derivative and line shape analysis on data taken with two orders of magnitude less acquisition time. The importance of our method lies in its applicability to any multidimensional spectral data that are susceptible to statistical noise.Comment: 8 pages, 8 figure

Small Fermi pockets intertwined with charge stripes and pair density wave order in a kagome superconductor

The kagome superconductor family AV3Sb5 (A=Cs, K, Rb) emerged as an exciting platform to study exotic Fermi surface instabilities. Here we use spectroscopic-imaging scanning tunneling microscopy (SI-STM) and angle-resolved photoemission spectroscopy (ARPES) to reveal how the surprising cascade of higher and lower-dimensional density waves in CsV3Sb5 is intimately tied to a set of small reconstructed Fermi pockets. ARPES measurements visualize the formation of these pockets generated by a 3D charge density wave transition. The pockets are connected by dispersive q* wave vectors observed in Fourier transforms of STM differential conductance maps. As the additional 1D charge order emerges at a lower temperature, q* wave vectors become substantially renormalized, signaling further reconstruction of the Fermi pockets. Remarkably, in the superconducting state, the superconducting gap modulations give rise to an in-plane Cooper pair-density-wave at the same q* wave vectors. Our work demonstrates the intrinsic origin of the charge-stripes and the pair-density-wave in CsV3Sb5 and their relationship to the Fermi pockets. These experiments uncover a unique scenario of how Fermi pockets generated by a parent charge density wave state can provide a favorable platform for the emergence of additional density waves

Interleukin-7 enhances in vitro development and blastocyst quality in porcine parthenogenetic embryos

Interleukin-7 (IL-7), a vital factor that affects cell development, proliferation, and survival, plays an important role in oocyte maturation. However, its role in embryonic development remains unknown. Therefore, in this study, we aimed to investigate the effects of IL-7 supplementation on in vitro culture (IVC) of porcine embryos after parthenogenetic activation (PA) based on characteristics such as cleavage, blastocyst formation rate, intracellular glutathione (GSH) and reactive oxygen species (ROS) levels in cleaved embryos, total cell number, apoptosis rate, and cell lineage specification in blastocysts. Immunofluorescence revealed that IL-7 and its receptor, IL-7Rα (IL-7R) localized in the cytoplasm of porcine parthenote embryos. By supplementing the IVC medium (PZM5) with various concentrations of IL-7, an optimal concentration that enhanced embryonic development, promoted intracellular GSH, and decreased ROS levels in the cleavage stage during porcine embryo IVC was determined. Investigation of mRNA expression patterns via qRT-PCR suggested that IL-7 possibly regulated maternal mRNA clearance and zygotic genome activation. Furthermore, IL-7 supplementation reduced blastocyst apoptosis, enhanced the expression of the inner cell mass marker SOX2, and phosphorylated STAT5 levels in the blastocysts. Moreover, it altered the transcription patterns of genes that regulate apoptosis, IL-7 signaling, and development. Thus, we demonstrated the localization of IL-7 and IL-7R in porcine preimplantation embryos in vitro for the first time. Furthermore, we suggest that IL-7 supplementation can be employed to enhance embryonic development and blastocyst quality based on the activation of the transcripts of genes that are involved in developmental competence and IL-7 signaling during in vitro porcine embryo development following PA

Localization and role of Rab3B in the regulation of pancreatic exocytosis

Includes bibliographical references (pages [64]-71)The present study sought to establish the presence of rab3B, a small molecular weight G protein, and determine its role in the promotion of secretion in exocrine pancreatic cells. Specifically, the goal of the study was to determine whether rab3B is located on zymogen granule membranes and whether the protein is involved in the regulation of fusion between zymogen granule and pancreatic apical plasma membrane. Using a rab3B antibody, Western blots of zymogen granule membrane fractions revealed the presence of a rab3B isoform. Measurements of granule K+ transport showed that ATP inhibited the transport in a dose-dependent manner and that inhibition was overridden by addition of mastoparan, a known GTPase-activating factor. Mastoparan also enhanced the rate of membrane fusion by 153% over controls. These experiments also suggested that the endogenous granule K+ transport pathway is associated with the enhanced fusion rate because mastoparan failed to stimulate fusion in KCI-free solutions. The results of the immunoblotting and the ability of mastoparan to stimulate K+ transport and fusion suggest that a small molecular weight G protein represented by rab3B is present in secretory granules and may play a role in promoting granule K+ transport-mediated exocytosis in pancreatic secretion.M.S. (Master of Science