Predictive Modelling of Quantum Process with Neural Networks

Complete characterization of an unknown quantum process can be achieved by process tomography, or, for continuous time processes, by Hamiltonian learning. However, such a characterization becomes unfeasible for high dimensional quantum systems. In this paper, we develop the first neural network algorithm for predicting the behavior of an unknown quantum process when applied on a given ensemble of input states. The network is trained with classical data obtained from measurements on a few pairs of input/output quantum states. After training, it can be used to predict the measurement statistics of a set of measurements of interest performed on the output state corresponding to any input in the state ensemble. Besides learning a quantum gate or quantum circuit, our model can also be applied to the task of learning a noisy quantum evolution and predicting the measurement statistics on a time-evolving quantum state. We show numerical results using our neural network model for various relevant processes in quantum computing, quantum many-body physics, and quantum optics.Comment: 12 pages, 7 figure

Submerzni uzgoj gljiva u bioreaktorima – izazovi, dostignuća i budućnost proizvodnje

Medicinal mushrooms have profound health-promoting benefits. Recently, a number of substances of mushroom origin have been isolated, identified and shown to have physiological activities, such as antitumor, immunomodulating, cardiovascular, antihypercholesterolemia, antibacterial, antiviral, antiparasitic, hepatoprotective, and antidiabetic activities. Currently, commercial products from medicinal mushrooms are mostly obtained through the field-cultivation of the fruiting body. However, in this case it is difficult to control the quality of the final product. Submerged fermentation of the mycelial form of mushroom-producing fungi has received much attention as a promising alternative for efficient production of the biomass of medicinal mushrooms and their active metabolites. However, in order for the production to be successful at industrial scale, various technical problems need to be solved, including characterization of the variations that occur during the submerged cultivation of mushrooms in bioreactors and their effects on growth and product formation. This review outlines the major factors that affect the submerged cultivation of mushrooms in bioreactors, including oxygen supply, shear and mixing, morphology and rheology, as well as two-stage cultivation strategies and high-cell-density cultivation strategies such as fed-batch fermentation.Medicinske gljive pozitivno djeluju na ljudsko zdravlje. U novije vrijeme izolirane su brojne tvari iz gljiva koje utječu na fiziološke procese i imaju antitumorski, imunomodulacijski i kardiovaskularni učinak, snizuju kolesterol, imaju antibakterijski, antivirusni, antiparazitski i hepatoprotektivni učinak i sprečavaju pojavu dijabetesa. Komercijalni proizvodi dobivaju se uzgojem medicinskih gljiva na polju. Međutim, tim se postupkom teško kontrolira kakvoća gotovog proizvoda. Submerzna fermentacija micelija gljiva moguća je alternativa za uspješnu proizvodnju biomase medicinskih gljiva i njihovih aktivnih metabolita. Međutim, da bi se postigla uspješna industrijska proizvodnja, treba riješiti razne tehničke probleme, između ostalog odrediti odstupanja pri submerznom uzgoju gljiva u bioreaktorima i njihov utjecaj na rast i formiranje gotovog proizvoda. U ovom se revijalnom prikazu razmatraju glavni faktori utjecaja na submerzni uzgoj gljiva u bioreaktorima, a to su opskrba kisikom, posmično naprezanje i miješanje, te morfologija i reologija, opisuje strategija uzgoja gljiva u dvije faze te proizvodnja stanica velike gustoće šaržnom fermentacijom

Submerzni uzgoj gljiva u bioreaktorima – izazovi, dostignuća i budućnost proizvodnje

Medicinal mushrooms have profound health-promoting benefits. Recently, a number of substances of mushroom origin have been isolated, identified and shown to have physiological activities, such as antitumor, immunomodulating, cardiovascular, antihypercholesterolemia, antibacterial, antiviral, antiparasitic, hepatoprotective, and antidiabetic activities. Currently, commercial products from medicinal mushrooms are mostly obtained through the field-cultivation of the fruiting body. However, in this case it is difficult to control the quality of the final product. Submerged fermentation of the mycelial form of mushroom-producing fungi has received much attention as a promising alternative for efficient production of the biomass of medicinal mushrooms and their active metabolites. However, in order for the production to be successful at industrial scale, various technical problems need to be solved, including characterization of the variations that occur during the submerged cultivation of mushrooms in bioreactors and their effects on growth and product formation. This review outlines the major factors that affect the submerged cultivation of mushrooms in bioreactors, including oxygen supply, shear and mixing, morphology and rheology, as well as two-stage cultivation strategies and high-cell-density cultivation strategies such as fed-batch fermentation.Medicinske gljive pozitivno djeluju na ljudsko zdravlje. U novije vrijeme izolirane su brojne tvari iz gljiva koje utječu na fiziološke procese i imaju antitumorski, imunomodulacijski i kardiovaskularni učinak, snizuju kolesterol, imaju antibakterijski, antivirusni, antiparazitski i hepatoprotektivni učinak i sprečavaju pojavu dijabetesa. Komercijalni proizvodi dobivaju se uzgojem medicinskih gljiva na polju. Međutim, tim se postupkom teško kontrolira kakvoća gotovog proizvoda. Submerzna fermentacija micelija gljiva moguća je alternativa za uspješnu proizvodnju biomase medicinskih gljiva i njihovih aktivnih metabolita. Međutim, da bi se postigla uspješna industrijska proizvodnja, treba riješiti razne tehničke probleme, između ostalog odrediti odstupanja pri submerznom uzgoju gljiva u bioreaktorima i njihov utjecaj na rast i formiranje gotovog proizvoda. U ovom se revijalnom prikazu razmatraju glavni faktori utjecaja na submerzni uzgoj gljiva u bioreaktorima, a to su opskrba kisikom, posmično naprezanje i miješanje, te morfologija i reologija, opisuje strategija uzgoja gljiva u dvije faze te proizvodnja stanica velike gustoće šaržnom fermentacijom

Apocynin Improves Insulin Resistance through Suppressing Inflammation in High-Fat Diet-Induced Obese Mice

We investigated the effects of apocynin on high-fat diet- (HFD-) induced insulin resistance in C57BL/6 mice. After 12 weeks of HFD, the mice that exhibited insulin resistance then received 5 weeks of apocynin (2.4 g/L, in water). Following apocynin treatment, fasting glucose, insulin, and glucose tolerance test showed significant improvement in insulin sensitivity in HFD-fed mice. We demonstrated that serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and leptin were remarkably reduced with apocynin treatment. We also found that mRNA expression of TNF-α, IL-6, and monocyte chemoattractant protein-1 (MCP-1) in the liver and mRNA expression of TNF-α, IL-6, MCP-1, and leptin in adipose tissue were suppressed by apocynin. Furthermore, the activity of transcription factor NF-κB in the liver was significantly suppressed with apocynin treatment. These results suggest that apocynin may reduce inflammatory factors in the blood, liver, and adipose tissue, resulting in amelioration of insulin resistance in HFD-fed mice

Biphenyl-3,3′,4,4′-tetra­carboxylic acid dihydrate

The asymmetric unit of the title compound, C16H10O8·2H2O, contains one-half of the centrosymmetric organic mol­ecule and one water mol­ecule. The dihedral angles between the carboxyl­ate groups and the adjacent phenyl ring are 71.31 (3) and 16.67 (3)°, while the carboxyl­ate groups are oriented at a dihedral angle of 72.01 (3)°. In the crystal structure, inter­molecular O—H⋯O and bifurcated O—H⋯(O,O) hydrogen bonds link the mol­ecules to form a three-dimensional supra­molecular network

2-(o-Tol­yloxy)benzoic acid

In the crystal structure of the title compound, C14H12O3, mol­ecules are linked via inter­molecular O—H⋯O hydrogen bonds, resulting in dimer formation. The dihedral angle between the two phenyl rings is 76.2 (2)°

Methylation status of DDIT3 gene in Chronic Myeloid Leukemia

<p>Abstract</p> <p>Background</p> <p>DNA-damage-inducible transcript 3 (<it>DDIT3</it>), a candidate tumor suppressor gene (TSG), has been found involved in the regulation of cellular growth and differentiation. The epigenetic changes of TSGs are recently recognized as an abnormal mechanism contributing to the development of chronic myeloid leukemia (CML). The aim of this study was to investigate the methylation status of <it>DDIT3 </it>gene in CML patients.</p> <p>Methods</p> <p>The methylation status of <it>DDIT3 </it>promoter was detected in the bone marrow mononuclear cells from 53 patients with CML using methylation-specific PCR (MSP). The expression levels of <it>DDIT3 </it>and <it>bcr/abl </it>transcript were determined by real-time quantitative PCR (RQ-PCR). Clinical data of these patients were collected and analyzed.</p> <p>Results</p> <p>The aberrant methylation of <it>DDIT3 </it>gene promoter was found in 35 of 53 (66%) CML cases. Correlation was not found between <it>DDIT3 </it>promoter hypermethylation and the age, sex, hemoglobin concentration, platelet counts, chromosomal abnormalities, <it>bcr/abl </it>transcript, and staging of CML patients (<it>P </it>> 0.05), but found between <it>DDIT3 </it>promoter hypermethylation and WBC counts of CML cases (R = 0.781, <it>P </it>< 0.001). The level of <it>DDIT3 </it>transcript in CML patients was significantly lower than that in controls (median 3.28 vs 19.69, <it>P </it>< 0.001), however, there was no difference in the level of <it>DDIT3 </it>transcript between methylation-positive CML cases (0.05-65.32, median 2.13) and methylation- negative CML cases (0.12-126.04, median 3.92) (<it>P </it>> 0.05).</p> <p>Conclusion</p> <p>Our results demonstrate that aberrant methylation of <it>DDIT3 </it>occurs in CML frequently.</p

Dendrobium officinale

Background. Dendrobium officinale (DO) Kimura et Migo is a precious Chinese herb that is considered beneficial for health due to its antioxidant and antidiabetes properties, and so on. In this research, we try to determine the preventive effect of DO on the early complications of STZ-induced diabetic rats. Methods. Type 1 diabetic rats were produced with a single intraperitoneal injection of STZ (50 mg/kg). DO (1 g/kg/day) was then orally administered for 5 weeks. Blood glucose, TC, TG, BUN, CREA, and GSH-PX levels were determined, and electroretinographic activity and hypoalgesia were investigated. Pathological sections of the eyes, hearts, aortas, kidneys, and livers were analyzed. Results. Treatment with DO significantly attenuated the serum levels of TC, TG, BUN, and CREA, markedly increased the amplitudes of ERG a- and b-waves and Ops, and reduced the hypoalgesia and histopathological changes of vital organs induced by hyperglycemia. The protective effect of DO in diabetic rats may be associated with its antioxidant activity, as evidenced by the marked increase in the serum level of glutathione peroxidase. However, DO had no significant effect on blood glucose levels and bodyweight of diabetic rats. Conclusions. DO supplementation is an effective treatment to prevent STZ-induced diabetic complications