Harvesting electrical energy using plasmon-enhanced light pressure in a platinum cut cone

We have designed a method of harvesting electrical energy using plasmon-enhanced light pressure. A device was fabricated as a cut cone structure that optimizes light collection so that the weak incident light pressure can be sufficiently enhanced inside the cut cone to generate electrical energy. An increase in the device's current output is a strong indication that the pressure of incident light has been enhanced by the surface plasmons on a platinum layer inside the cut cone. The electrical energy harvested in a few minutes by irradiating pulsed laser light on a single micro device was possible to illuminate a blue LED

Piezoelectric energy harvesting using solar radiation pressure enhanced by surface plasmons at visible to near-infrared wavelengths

A light-pressure electric generator (LPEG) device, which harvests piezoelectric energy using solar radiation enhanced by surface plasmons (SPs), is demonstrated. The design of the device is motivated by the need to drastically increase the power output of existing piezoelectric devices based on SP resonance. The solar radiation pressure can be used as an energy source by employing an indium tin oxide (ITO)/Ag double layer to excite the SPs in the near-infrared (NIR) and visible light regions. The LPEG with the ITO layer generates an open-circuit voltage of 295 mV, a short-circuit current of 3.78 μA, and a power of 532.3 μW cm−2 under a solar simulator. The power of the LPEG device incorporating the ITO layer increased by 38% compared to the device without the ITO layer. The effect of the ITO layer on the electrical output of the LPEG was analyzed in detail by measuring the electrical output when visible and NIR lights are incident on the device using optical bandpass filters. In addition, finite-difference time-domain simulation confirmed that the pressure of the incident light can be further amplified by the ITO/Ag double layer. Finally, the energy harvested from the LPEG was stored in capacitors to successfully illuminate red light-emitting diodes

ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state

Background: The progression of prostate cancer (PC) to the highly aggressive metastatic castration-resistant prostate cancer (mCRPC) or neuroendocrine prostate cancer (NEPC) is a fatal condition and the underlying molecular mechanisms are poorly understood. Here, we identified the novel transcriptional factor ZNF507 as a key mediator in the progression of PC to an aggressive state. Methods: We analyzed ZNF507 expression in the data from various human PC database and high-grade PC patient samples. By establishment of ZNF507 knockdown and overexpression human PC cell lines, we assessed in vitro PC phenotype changes including cell proliferation, survival, migration and invasion. By performing microarray with ZNF507 knockdown PC cells, we profiled the gene clusters affected by ZNF507 knockdown. Moreover, ZNF507 regulated key signal was evaluated by dual-luciferase reporter and chromatin immunoprecipitation (ChIP) assays. Finally, we performed xenograft and in vivo metastasis assay to confirm the effect of ZNF507 knockdown in PC cells. Results: We found that ZNF507 expression was increased, particularly in the highly graded PC. ZNF507 was also found to be associated with metastatic PC of a high grade. Loss- or gain-of-function–based analysis revealed that ZNF507 promotes the growth, survival, proliferation, and metastatic properties of PC (e.g., epithelial-mesenchymal transition) by upregulating TGF-β signaling. Profiling of gene clusters affected by ZNF507 knockdown revealed that ZNF507 positively regulated the transcription of TGFBR1, MAP3K8, and FURIN, which in turn promoted the progression of PC to highly metastatic and aggressive state. Conclusions: Our findings suggest that ZNF507 is a novel key regulator of TGF-β signaling in the progression of malignant PC and could be a promising target for studying the development of advanced metastatic PCs. © 2021, The Author(s).1