A Study of Social Support for Patients with Mental Disorders in Rehabilitation Stations

 In recent years, the prevalence of mental disorders has increased dramatically and has become a disease that seriously endangers people’s physical and mental health. According to the World Health Organization (WHO), about 1 billion people worldwide are suffering from mental disorders. However, the social organizations specializing in serving people with mental disorders in China are inadequate and have limited power, and the cooperative ties among welfare providers are not close enough, which cause the failing to provide efficient support and services for people with mental disorders. This study adopts a field research method to explore the complementary cooperative relationship among various welfare providers and the social support received by patients with mental disorders in the rehabilitation process, and to promote the social support role of various welfare providers in education, employment and medical care in the welfare services for the group of patients with mental disorders, using 17 rehabilitation stations in Suzhou City A District as the research subjects.

Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer.

Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is a member of dual-specificity kinase family, which could phosphorylate both Ser/Thr and Tyr substrates. The role of DYRK2 in human cancer remains controversial. For example, overexpression of DYRK2 predicts a better survival in human non-small cell lung cancer. In contrast, amplification of DYRK2 gene occurs in esophageal/lung adenocarcinoma, implying the role of DYRK2 as a potential oncogene. However, its clinical role in colorectal cancer (CRC) has not been explored. In this study, we analyzed the expression of DYRK2 from Oncomine database and found that DYRK2 level is lower in primary or metastatic CRC compared to adjacent normal colon tissue or non-metastatic CRC, respectively, in 6 colorectal carcinoma data sets. The correlation between DYRK2 expression and clinical outcome in 181 CRC patients was also investigated by real-time PCR and IHC. DYRK2 expression was significantly down-regulated in colorectal cancer tissues compared with adjacent non-tumorous tissues. Functional studies confirmed that DYRK2 inhibited cell invasion and migration in both HCT116 and SW480 cells and functioned as a tumor suppressor in CRC cells. Furthermore, the lower DYRK2 levels were correlated with tumor sites (P = 0.023), advanced clinical stages (P = 0.006) and shorter survival in the advanced clinical stages. Univariate and multivariate analyses indicated that DYRK2 expression was an independent prognostic factor (P < 0.001). Taking all, we concluded that DYRK2 a novel prognostic biomarker of human colorectal cancer

Role of District Education Officials in Quality Education in Nanguan and Shikarpur Districts: A Comparative Study Between China and Pakistan

The purpose of the study is to understand the role of district educational official(s) in bringing quality in education in schools at district level with respect to the educational objectives at ministry of education level, provincial education department level and at local district level. Two districts; Nanguan district (China) and Shikarpur district (Pakistan) are studied and compared with each other because of the convenience for researcher and good friendship between these two countries. This is comparative study, which adopts descriptive type of research, and qualitative research design. Semi-structured interview and observation report; are used as research tools for data collection. Purposive sampling type is adopted as to make this study possible to complete and having strong relationship of district educational officials’ interventions with quality in education in variety of schools. District educational official(s) and four schools (primary, junior secondary, countryside and city) in each district are visited. Results of the study show that district educational officials of both districts are aware about the educational objectives at these three levels of educational administration. They perceive quality in education differently with respect to their local and contextual environment. Arranging different trainings for school heads and teachers and calling meetings are the only two similar interventions among these two district educational officials that they take to achieve quality in education; rest interventions are totally different. There seems more implication of the interventions of the Nanguan district education bureau official in the schools than the implication of the interventions of Shikarpur district educational officials in schools; as to achieve their perceived quality in education in their respective districts

Efficiency Enhancement in Polymer Solar Cells With a Polar Small Molecule Both at Interface and in the Bulk Heterojunction Layer

The polar molecules, including ferroelectric materials with large dipole moments, have been applied as interfacial layers to increase the efficiency of organic solar cells by increasing the bounded charge separation, tuning the energy levels, etc. Here, we report a small polar molecule 2-cyano-3- (4-(diphenylamino) phenyl)acrylic acid (TPACA) that can be either blended in the active layer or at the polymer/electrode interface to increase the efficiency of organic solar cell devices after poling. It is found that the built-in potential of the device is increased by 0.2 V after poling under negative bias. Blending TPACA into the active layer has shown to be a universal method to increase the efficiency of polymer solar cells. The efficiency is increased by 30–90% for all the polymer:fullerene systems tested, with the highest efficiency reaching 7.83% for the poly[4,8-bis-(2-ethyl-hexyl-thiophene-5-yl)-benzo[1,2-b:4,5-b’]dithiophene-2,6-diyl]-alt-[2-(2’-ethyl-hexanoyl)-thieno[3,4-b]thiophen-4,6-diyl]: [6,6]-phenyl-C71 -butyric acid methyl ester (PBDTTT-CT:PC70BM) system

Explaining the differences of gait patterns between high and low-mileage runners with machine learning

Running gait patterns have implications for revealing the causes of injuries between higher-mileage runners and low-mileage runners. However, there is limited research on the possible relationships between running gait patterns and weekly running mileages. In recent years, machine learning algorithms have been used for pattern recognition and classification of gait features to emphasize the uniqueness of gait patterns. However, they all have a representative problem of being a black box that often lacks the interpretability of the predicted results of the classifier. Therefore, this study was conducted using a Deep Neural Network (DNN) model and Layer-wise Relevance Propagation (LRP) technology to investigate the differences in running gait patterns between higher-mileage runners and low-mileage runners. It was found that the ankle and knee provide considerable information to recognize gait features, especially in the sagittal and transverse planes. This may be the reason why high-mileage and low-mileage runners have different injury patterns due to their different gait patterns. The early stages of stance are very important in gait pattern recognition because the pattern contains effective information related to gait. The findings of the study noted that LRP completes a feasible interpretation of the predicted results of the model, thus providing more interesting insights and more effective information for analyzing gait patterns

Improvement and Mechanism of Ganoderma lucidum Polysaccharides and Its Flora Metabolites on Insulin Resistance in HepG2 Cells

Objective: To investigate the effects of Ganoderma lucidum polysaccharides and its flora metabolites on the insulin resistance status of HepG2 cells and its mechanisms. Methods: Insulin resistant HepG2 (IR-HepG2) model was established with the combination of insulin (10−3 µmol/L) and dexamethasone (10 µmol/L). The cytotoxicity of Ganoderma lucidum polysaccharides (GLP) and Ganoderma lucidum polysaccharide flora metabolite (GLP-F) was evaluated using the CCK-8 method. The effects of GLP and GLP-F on glucose consumption and glycogen synthesis in IR-HepG2 cells were evaluated using the glucose kit and glycogen kit methods. Western blot assay was used to detect the effects of GLP and GLP-F on the phosphorylation or expression of IRS-1, AKT, GSK-3β, GLUT2, and PEPCK, key proteins in the insulin signaling cascade in IR-HepG2 cells. Results: Both GLP and GLP-F significantly increased glucose uptake and glycogen synthesis in IR-HepG2 cells (P<0.05). GLP-F promoted glucose consumption in IR-HepG2 cells significantly more than GLP (P<0.05). Western blot experiments showed that both GLP and GLP-F promoted IR-HepG2 cells IRS-1, P-AKT, P-GSK-3β, GLUT2 protein expression and inhibited PEPCK protein expression, and the inhibitory utility of GLP-F on PEPCK was significantly higher than that of GLP (P<0.05). Conclusions: GLP and its metabolism by intestinal flora-mediated production of GLP-F have the same biological effect of alleviating hepatic insulin resistance, and GLP-F has a more significant effect than GLP in promoting glucose consumption in IR-HepG2 cells and inhibiting their gluconeogenic rate-limiting enzyme activity

Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer

Helicobacter pylori (H. pylori) infection is strongly associated with gastric cancer. However, only a minority of infected individuals ever develop gastric cancer. This risk stratification may be in part due to differences among strains. The relationship between neutrophil-activating protein (NapA) and gastric cancer is unclear. The purpose of this study is to evaluate the significance of NapA as a biomarker in gastric cancer. We used enzyme linked immunosorbent assay (ELISA) to determine the status of H. pylori infection. Indirect ELISA method was used for detection of NapA antibody titer in the serum of H. pyloriinfected individuals. Unconditional logistic regressions were adopted to analyze the variables and determine the association of NapA and gastric cancer. The results of study indicated serum H. pylori NapA antibody level were associated with a reduced risk for development of gastric cancer. It may be used in conjugation with other indicators for gastric cancer detection

Association of GSDMD with microvascular-ischemia reperfusion injury after ST-elevation myocardial infarction

ObjectivesLittle is known about the clinical prognosis of gasdermin D (GSDMD) in patients with ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate the association of GSDMD with microvascular injury, infarction size (IS), left ventricular ejection fraction (LVEF), and major adverse cardiac events (MACEs), in STEMI patients with primary percutaneous coronary intervention (pPCI).MethodsWe retrospectively analyzed 120 prospectively enrolled STEMI patients (median age 53 years, 80% men) treated with pPCI between 2020 and 2021 who underwent serum GSDMD assessment and cardiac magnetic resonance (CMR) within 48 h post-reperfusion; CMR was also performed at one year follow-up.ResultsMicrovascular obstruction was observed in 37 patients (31%). GSDMD concentrations ≧ median (13 ng/L) in patients were associated with a higher risk of microvascular obstruction and IMH (46% vs. 19%, P = 0.003; 31% vs. 13%, P = 0.02, respectively), as well as with a lower LVEF both in the acute phase after infarction (35% vs. 54%, P &lt; 0.001) and in the chronic phase (42% vs. 56%, P &lt; 0.001), larger IS in the acute (32% vs. 15%, P &lt; 0.001) and in the chronic phases (26% vs. 11%, P &lt; 0.001), and larger left ventricular volumes (119 ± 20 vs. 98 ± 14, P = 0.003) by CMR. Univariable and multivariable Cox regression analysis results showed that patients with GSDMD concentrations ≧ median (13 ng/L) had a higher incidence of MACE (P &lt; 0.05).ConclusionsHigh GSDMD concentrations in STEMI patients are associated with microvascular injury (including MVO and IMH), which is a powerful MACE predictor. Nevertheless, the therapeutic implications of this relation need further research