A Unified Theory for the Effects of Stellar Perturbations and Galactic Tides on Oort Cloud Comets

We examine the effects of passing field stars on the angular momentum of a nearly radial orbit of an Oort cloud comet bound to the Sun. We derive the probability density function (PDF) of the change in angular momentum from one stellar encounter, assuming a uniform and isotropic field of perturbers. We show that the total angular momentum follows a Levy flight, and determine its distribution function. If there is an asymmetry in the directional distribution of perturber velocities, the marginal probability distribution of each component of the angular momentum vector can be different. The constant torque attributed to Galactic tides arises from a non-cancellation of perturbations with an impact parameter of order the semimajor axis of the comet. When the close encounters are rare, the angular momentum is best modeled by the stochastic growth of stellar encounters. If trajectories passing between the comet and sun occur frequently, the angular momentum exhibits the coherent growth attributed to the Galactic tides.Comment: 8 pages, 2 figures; accepted to A

Considerations on the magnitude distributions of the Kuiper belt and of the Jupiter Trojans

By examining the absolute magnitude (H) distributions (hereafter HD) of the cold and hot populations in the Kuiper belt and of the Trojans of Jupiter, we find evidence that the Trojans have been captured from the outer part of the primordial trans-Neptunian planetesimal disk. We develop a sketch model of the HDs in the inner and outer parts of the disk that is consistent with the observed distributions and with the dynamical evolution scenario known as the `Nice model'. This leads us to predict that the HD of hot population should have the same slope of the HD of the cold population for 6.5 < H < 9, both as steep as the slope of the Trojans' HD. Current data partially support this prediction, but future observations are needed to clarify this issue. Because the HD of the Trojans rolls over at H~9 to a collisional equilibrium slope that should have been acquired when the Trojans were still embedded in the primordial trans-Neptunian disk, our model implies that the same roll-over should characterize the HDs of the Kuiper belt populations, in agreement with the results of Bernstein et al. (2004) and Fuentes and Holman (2008). Finally, we show that the constraint on the total mass of the primordial trans-Neptunian disk imposed by the Nice model implies that it is unlikely that the cold population formed beyond 35 AU.Comment: Icarus (2009) in pres

Observed Binary Fraction Sets Limits on the Extent of Collisional Grinding in the Kuiper Belt

The size distribution in the cold classical Kuiper belt can be approximated by two idealized power laws: one with steep slope for radii R>R* and one with shallow slope for R<R*, where R*~25-50 km. Previous works suggested that the SFD roll-over at R* can be the result of extensive collisional grinding in the Kuiper belt that led to the catastrophic disruption of most bodies with R<R*. Here we use a new code to test the effect of collisions in the Kuiper belt. We find that the observed roll-over could indeed be explained by collisional grinding provided that the initial mass in large bodies was much larger than the one in the present Kuiper belt, and was dynamically depleted. In addition to the size distribution changes, our code also tracks the effects of collisions on binary systems. We find that it is generally easier to dissolve wide binary systems, such as the ones existing in the cold Kuiper belt today, than to catastrophically disrupt objects with R~R*. Thus, the binary survival sets important limits on the extent of collisional grinding in the Kuiper belt. We find that the extensive collisional grinding required to produce the SFD roll-over at R* would imply a strong gradient of the binary fraction with R and separation, because it is generally easier to dissolve binaries with small components and/or those with wide orbits. The expected binary fraction for R<R* is <0.1. The present observational data do not show such a gradient. Instead, they suggest a large binary fraction of ~0.4 for R=30-40 km. This may indicate that the roll-over was not produced by disruptive collisions, but is instead a fossil remnant of the KBO formation process.Comment: The Astronomical Journal, in pres

Profundizando en la estenósis aórtica valvular: análisis proteómico del plasma

Comunicaciones a congreso

An Optimal Protocol to Analyze the Rat Spinal Cord Proteome

Since the function of the spinal cord depends on the proteins found there, better defing the normal Spinal Cord Proteome is an important and challenging task. Although brain and cerebrospinal fluid samples from patients with different central nervous system (CNS) disorders have been studied, a thorough examination of specific spinal cord proteins and the changes induced by injury or associated to conditions such as neurodegeneration, spasticity and neuropathies has yet to be performed. In the present study, we aimed to describe total protein content in the spinal cord of healthy rats, employing different proteomics tools. Accordingly, we have developed a fast, easy, and reproducible sequential protocol for protein extraction from rat spinal cords. We employed conventional two dimensional electrophoresis (2DE) in different pH ranges (eg. 4–7, 3–11 NL) combined with identification by mass spectrometry (MALDI-TOF/TOF), as well as first dimension protein separation combined with Liquid Chromatography Mass Spectrometry/Mass Spectrometry (LC-MS/MS) to maximise the benefits of this technology. The value of these techniques is demonstrated here by the identification of several proteins known to be associated with neuroglial structures, neurotransmission, cell survival and nerve growth in the central nervous system. Furthermore this study identified many spinal proteins that have not previously been described in the literature and which may play an important role as either sensitive biomarkers of dysfunction or of recovery after Spinal Cord Injury

Estudio de la Estenosis Aórtica Valvular desde un punto de vista proteómico

Comunicaciones a congreso

Proteomics - A Powerful Tool to Deepen the Molecular Mechanisms of Aortic Stenosis Disease

We thank the grants from the Instituto de Salud Carlos III (FIS PI070537), Fondo de Investigación Sanitaria de Castilla la Mancha (FISCAM, PI2008/08), Fondo de Investigación Sanitaria de Castilla la Mancha (FISCAM PI2008/28) and Redes Temáticas de Investigación Cooperativa, FONDOS FEDER (RD06/0014/1015)Depto. de Genética, Fisiología y MicrobiologíaFac. de Ciencias BiológicasTRUEpu