Vascularites au cours de l'infection par le VIH (à propos de 15 observations)

BORDEAUX2-BU Santé (330632101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Strychnine, old still actual poison: description of poisoning cases reported to French Poison Control Centers over the past thirteen years

In January 2020, a fatal case of strychnine exposure has been reported to our Poison Control Center (PCC), highlighting that strychnine poisoning is still occurring. This poisoning led us to collect the cases of strychnine poisoning reported to the French PCC. During the last thirteen years, we encountered 94 cases of strychnine poisoning. The circumstance of exposure was mainly suicide attempts. Strychnine blood levels were documented for 11 of the 94 cases. During the period of the study, 15 deaths occurred that led us to consider that strychnine exposure is a rare but serious poisoning

A highly virulent variant of HIV-1 circulating in the Netherlands

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence