Rôle des cytokines dans la tolérance de transplantation et l'immunopathologie induites par l'injection néonatale d'alloantigènes chez la souris

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

La tolérance aux allogreffes: L'Europe relève le défi

Recent developments in basic and translational immunology open new exciting perspectives for the induction of transplantation tolerance in the clinic. However, a number of hurdles still need to be overcome before immunosuppressive drugs can be safely withdrawn in solid organ transplant recipients. With this background, the European Commission recently launched several initiatives to tackle unmet needs in transplantation medicine. Herein, we focus attention on the RISET project, an ongoing collaborative effort across the European Union aiming at minimization of immunosuppression on the basis of validated biomarkers.SCOPUS: sh.jinfo:eu-repo/semantics/publishe

Transplantation tolerance: European union meets the challenge

info:eu-repo/semantics/publishe

The unbearable lightness of therapeutic algorithms in colorectal liver metastasis

SCOPUS: ed.jinfo:eu-repo/semantics/publishe

Concept of combining parts of different bodies into one functioning entity is not new. Introduction--historical perspective.

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Treatment of colon endoscopic perforations.

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Early survival and safety of ALPPS first report of the international ALPPS registry

Objectives: To assess safety and outcomes of the novel 2-stage hepatectomy, Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS), using an international registry. Background: ALPPS induces accelerated growth of small future liver remnants (FLR) to allow curative resection of liver tumors. There is concern about safety based on reports of higher morbidity and mortality. Methods: A Web-based data entry system was created with password access and data pseudoencryption (NCT01924741). All patients with complete 90-day data were included. Multivariate logistic regression analysis was performed to identify independent risk factors for severe complications and mortality and volume growth of the FLR. Results: Complete data were available for 202 patients. A total of 141 (70%) patients had colorectal liver metastases (CRLM). Median starting standardized future liver remnants of 21% increased by 80% within a median of 7 days. Ninety-day mortality was 19/202 (9%). Severe complications including mortalities (Clavien-Dindo ≥IIIb) occurred in 27% of patients. Independent factors for severe complications were red blood cell transfusion [odds ratio (OR), 5.2), ALPPS stage I operating time greater than 300 minutes (OR, 4.4), age more than 60 years (OR, 3.8), and non-CRLM (OR, 2.7). Age, use of Pringle maneuver, and histologic changes led to less volume growth. In patients younger than 60 years with CRLM, 90-day mortality was similar to conventional 2-stage hepatectomies for CRLM. Conclusions: This is the first analysis of the ALPPS registry showing that ALPPS has increased perioperative morbidity and mortality in older patients but better outcomes in patients with CRLM.0SCOPUS: cp.jSCOPUS: cp.jinfo:eu-repo/semantics/publishe

Cholecystectomy in cirrhotic patients :PPPPPPitfalls and reasonable recommendations

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Comments on “intraoperative near-infrared fluorescence imaging using indocyanine green in colorectal carcinomatosis surgery: proof of concept”

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Hematopoietic stem cells as inducers of tolerance to solid organ transplants

Although significant barriers remain to be overcome before transplantation tolerance can be routinely induced in the clinic, new advances in hematopoietic stem cell biology and ongoing clinical investigations will undoubtedly allow accomplishment major steps in this direction in the near future. © 2004 Lippincott Williams & Wilkins.SCOPUS: re.jinfo:eu-repo/semantics/publishe