113 research outputs found
Rôle des cytokines dans la tolérance de transplantation et l'immunopathologie induites par l'injection néonatale d'alloantigènes chez la souris
SCOPUS: ar.jinfo:eu-repo/semantics/publishe
La tolérance aux allogreffes: L'Europe relève le défi
Recent developments in basic and translational immunology open new exciting perspectives for the induction of transplantation tolerance in the clinic. However, a number of hurdles still need to be overcome before immunosuppressive drugs can be safely withdrawn in solid organ transplant recipients. With this background, the European Commission recently launched several initiatives to tackle unmet needs in transplantation medicine. Herein, we focus attention on the RISET project, an ongoing collaborative effort across the European Union aiming at minimization of immunosuppression on the basis of validated biomarkers.SCOPUS: sh.jinfo:eu-repo/semantics/publishe
Transplantation tolerance: European union meets the challenge
info:eu-repo/semantics/publishe
The unbearable lightness of therapeutic algorithms in colorectal liver metastasis
SCOPUS: ed.jinfo:eu-repo/semantics/publishe
Concept of combining parts of different bodies into one functioning entity is not new. Introduction--historical perspective.
SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Early survival and safety of ALPPS first report of the international ALPPS registry
Objectives: To assess safety and outcomes of the novel 2-stage hepatectomy, Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS), using an international registry. Background: ALPPS induces accelerated growth of small future liver remnants (FLR) to allow curative resection of liver tumors. There is concern about safety based on reports of higher morbidity and mortality. Methods: A Web-based data entry system was created with password access and data pseudoencryption (NCT01924741). All patients with complete 90-day data were included. Multivariate logistic regression analysis was performed to identify independent risk factors for severe complications and mortality and volume growth of the FLR. Results: Complete data were available for 202 patients. A total of 141 (70%) patients had colorectal liver metastases (CRLM). Median starting standardized future liver remnants of 21% increased by 80% within a median of 7 days. Ninety-day mortality was 19/202 (9%). Severe complications including mortalities (Clavien-Dindo ≥IIIb) occurred in 27% of patients. Independent factors for severe complications were red blood cell transfusion [odds ratio (OR), 5.2), ALPPS stage I operating time greater than 300 minutes (OR, 4.4), age more than 60 years (OR, 3.8), and non-CRLM (OR, 2.7). Age, use of Pringle maneuver, and histologic changes led to less volume growth. In patients younger than 60 years with CRLM, 90-day mortality was similar to conventional 2-stage hepatectomies for CRLM. Conclusions: This is the first analysis of the ALPPS registry showing that ALPPS has increased perioperative morbidity and mortality in older patients but better outcomes in patients with CRLM.0SCOPUS: cp.jSCOPUS: cp.jinfo:eu-repo/semantics/publishe
Cholecystectomy in cirrhotic patients :PPPPPPitfalls and reasonable recommendations
SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Comments on “intraoperative near-infrared fluorescence imaging using indocyanine green in colorectal carcinomatosis surgery: proof of concept”
SCOPUS: le.jinfo:eu-repo/semantics/publishe
Use of molecular adsorbent recirculating system for treatment of refractory pruritus
SCOPUS: le.jFLWINinfo:eu-repo/semantics/publishe
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