Use of Old Order Anabaptist-Produced Publications to Develop an Injury Surveillance System for Old Order Populations

To achieve a clearer picture of injuries within Old Order Anabaptist communities, Purdue University’s Agricultural Safety and Health Program collaborated with the Young Center for Anabaptist and Pietist Studies at Elizabethtown College to conduct a pilot study on this topic. The team developed an injury surveillance system based not on traditional injury data sources and instruments but on data provided in Old Order-produced publications, specifically The Budget, Die Botschaft, and The Diary. While traditional surveillance methods have generally yielded injury data on less than 30 Old Order cases per year, the Old Order Injury Database, developed through the Purdue/Young Center collaboration, yielded data on 1,153 cases for the target year analyzed. While the primary focus of the study was farm-related injuries, it is believed that this type of surveillance system could be used by professionals in a variety of health-related fields to assist in gathering data and developing culturally appropriate interventions for Old Order groups

Use of Old Order Anabaptist-Produced Publications to Develop an Injury Surveillance System for Old Order Populations

To achieve a clearer picture of injuries within Old Order Anabaptist communities, Purdue University’s Agricultural Safety and Health Program collaborated with the Young Center for Anabaptist and Pietist Studies at Elizabethtown College to conduct a pilot study on this topic. The team developed an injury surveillance system based not on traditional injury data sources and instruments but on data provided in Old Order-produced publications, specifically The Budget, Die Botschaft, and The Diary. While traditional surveillance methods have generally yielded injury data on less than 30 Old Order cases per year, the Old Order Injury Database, developed through the Purdue/Young Center collaboration, yielded data on 1,153 cases for the target year analyzed. While the primary focus of the study was farm-related injuries, it is believed that this type of surveillance system could be used by professionals in a variety of health-related fields to assist in gathering data and developing culturally appropriate interventions for Old Order groups

Linked CSF reduction of phosphorylated tau and IL-8 in HIV associated neurocognitive disorder.

HIV-associated neurocognitive disorder (HAND) is a common condition in both developed and developing nations, but its cause is largely unknown. Previous research has inconsistently linked Alzheimer's disease (AD), viral burden, and inflammation to the onset of HAND in HIV-infected individuals. Here we simultaneously measured cerebrospinal fluid (CSF) levels of established amyloid and tau biomarkers for AD, viral copy numbers, and six key cytokines in 41 HIV-infected individuals off combination anti-retroviral therapy (14 with HAND) who underwent detailed clinical and neuropsychological characterization, and compared their CSF patterns with those from young healthy subjects, older healthy subjects with normal cognition, and older people with AD. HAND was associated with the lowest CSF levels of phosphorylated tau (p-Tau181) after accounting for age and race. We also found very high CSF levels of the pro-inflammatory interferon gamma-induced protein 10 (IP-10/CXCL10) in HIV regardless of cognition, but elevated CSF interleukin 8 (IL-8/CXCL8) only in HIV-NC but not HAND. Eleven HIV-infected subjects underwent repeat CSF collection six months later and showed strongly correlated longitudinal changes in p-Tau181 and IL-8 levels (R = 0.841). These data suggest reduced IL-8 relative to IP-10 and reduced p-Tau181 to characterize HAND

Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells.

Candida albicans is the most common cause of hematogenously disseminated and oropharyngeal candidiasis. Both of these diseases are characterized by fungal invasion of host cells. Previously, we have found that C. albicans hyphae invade endothelial cells and oral epithelial cells in vitro by inducing their own endocytosis. Therefore, we set out to identify the fungal surface protein and host cell receptors that mediate this process. We found that the C. albicans Als3 is required for the organism to be endocytosed by human umbilical vein endothelial cells and two different human oral epithelial lines. Affinity purification experiments with wild-type and an als3delta/als3delta mutant strain of C. albicans demonstrated that Als3 was required for C. albicans to bind to multiple host cell surface proteins, including N-cadherin on endothelial cells and E-cadherin on oral epithelial cells. Furthermore, latex beads coated with the recombinant N-terminal portion of Als3 were endocytosed by Chinese hamster ovary cells expressing human N-cadherin or E-cadherin, whereas control beads coated with bovine serum albumin were not. Molecular modeling of the interactions of the N-terminal region of Als3 with the ectodomains of N-cadherin and E-cadherin indicated that the binding parameters of Als3 to either cadherin are similar to those of cadherin-cadherin binding. Therefore, Als3 is a fungal invasin that mimics host cell cadherins and induces endocytosis by binding to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells. These results uncover the first known fungal invasin and provide evidence that C. albicans Als3 is a molecular mimic of human cadherins

Exploratory Chandra Observations of the Three Highest Redshift Quasars Known

We report on exploratory Chandra observations of the three highest redshift quasars known (z = 5.82, 5.99, and 6.28), all found in the Sloan Digital Sky Survey. These data, combined with a previous XMM-Newton observation of a z = 5.74 quasar, form a complete set of color-selected, z > 5.7 quasars. X-ray emission is detected from all of the quasars at levels that indicate that the X-ray to optical flux ratios of z ~ 6 optically selected quasars are similar to those of lower redshift quasars. The observations demonstrate that it will be feasible to obtain quality X-ray spectra of z ~ 6 quasars with current and future X-ray missions.Comment: 15 pages, ApJL, in press; small revisions to address referee Comment

Nonexponential Solid State 1H and 19F Spin–Lattice Relaxation, Single-crystal X-ray Diffraction, and Isolated-Molecule and Cluster Electronic Structure Calculations in an Organic Solid: Coupled Methyl Group Rotation and Methoxy Group Libration in 4,4′-Dimethoxyoctafluorobiphenyl

We investigate the relationship between intramolecular rotational dynamics and molecular and crystal structure in 4,4′-dimethoxyoctafluorobiphenyl. The techniques are electronic structure calculations, X-ray diffractometry, and 1H and 19F solid state nuclear magnetic resonance relaxation. We compute and measure barriers for coupled methyl group rotation and methoxy group libration. We compare the structure and the structure-motion relationship in 4,4′-dimethoxyoctafluorobiphenyl with the structure and the structure-motion relationship in related compounds in order to observe trends concerning the competition between intramolecular and intermolecular interactions. The 1H spin–lattice relaxation is nonexponential in both the high-temperature short-correlation time limit and in the low-temperature long-correlation time limit, albeit for different reasons. The 19F spin–lattice relaxation is nonexponential at low temperatures and it is exponential at high temperatures

Aquilegia, Vol. 34 No. 5, Winter 2010, Newsletter of the Colorado Native Plant Society

https://epublications.regis.edu/aquilegia/1135/thumbnail.jp

Belowground competition and the response of developing forest communities to atmospheric CO 2 and O 3

As human activity continues to increase CO 2 and O 3 , broad expanses of north temperate forests will be simultaneously exposed to elevated concentrations of these trace gases. Although both CO 2 and O 3 are potent modifiers of plant growth, we do not understand the extent to which they alter competition for limiting soil nutrients, like nitrogen (N). We quantified the acquisition of soil N in two 8-year-old communities composed of trembling aspen genotypes ( n = 5) and trembling aspen–paper birch which were exposed to factorial combinations of CO 2 (ambient and 560 ΜL L −1 ) and O 3 (ambient = 30–40 vs. 50–60 nL L −1 ). Tracer amount of 15 NH 4 + were applied to soil to determine how these trace gases altered the competitive ability of genotypes and species to acquire soil N. One year after isotope addition, we assessed N acquisition by measuring the amount of 15 N tracer contained in the plant canopy (i.e. recent N acquisition), as well as the total amount of canopy N (i.e. cumulative N acquisition). Exposure to elevated CO 2 differentially altered recent and cumulative N acquisition among aspen genotypes, changing the rank order in which they obtained soil N. Elevated O 3 also altered the rank order in which aspen genotypes obtained soil N by eliciting increases, decreases and no response among genotypes. If aspen genotypes respond similarly under field conditions, then rising concentrations of CO 2 and O 3 could alter the structure of aspen populations. In the aspen–birch community, elevated CO 2 increased recent N (i.e. 15 N) acquisition in birch (68%) to a greater extent than aspen (19%), suggesting that, over the course of this experiment, birch had gained a competitive advantage over aspen. The response of genotypes and species to rising CO 2 and O 3 concentrations, and how these responses are modified by competitive interactions, has the potential to change the future composition and productivity of northern temperate forests.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72323/1/j.1365-2486.2007.01436.x.pd

Joint Polar Satellite System (JPSS) Micrometeoroid and Orbital Debris (MMOD) Assessment

The Joint Polar Satellite System (JPSS) Project requested the NASA Engineering and Safety Center (NESC) conduct an independent evaluation of the Micrometeoroid and Orbital Debris (MMOD) models used in the latest JPSS MMOD risk assessment. The principal focus of the assessment was to compare Orbital Debris Engineering Model version 3 (ORDEM 3.0) with the Meteoroid and Space Debris Terrestrial Environment Reference version 2009 (MASTER-2009) and Aerospace Debris Environment Projection Tool (ADEPT) and provide recommendations to the JPSS Project regarding MMOD protection. The outcome of the NESC assessment is contained in this report

InP Heterojunction Bipolar Transistor Amplifiers to 255 GHz

Two single-stage InP heterojunction bipolar transistor (HBT) amplifiers operate at 184 and 255 GHz, using Northrop Grumman Corporation s InP HBT MMIC (monolithic microwave integrated circuit) technology. At the time of this reporting, these are reported to be the highest HBT amplifiers ever created. The purpose of the amplifier design is to evaluate the technology capability for high-frequency designs and verify the model for future development work