Ketamine kinetics in unmedicated and diazepam‐premedicated subjects

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109775/1/cptclpt1984235.pd

Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats

Varying doses of d-amphetamine were given i.p. to young (28 day old), adult (approximately 90 day old), and geriatric rats (approximately 2 years old). 30 min after injection, rats were sacrificed and ACH extracted and assayed by pyrolysis gas-liquid chromatography. Total brain acetylcholine (ACh) levels were not significantly different among the control animals in all three groups. d-Amphetamine, however, decreased total levels of ACh in young and geriatric rats without changing levels in adult animals. The changes in young rats were dose-related. These results suggest an important difference in brain cholinergic mechanisms depending upon age.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22339/1/0000784.pd