Human pharmacology of tranquilizing drugs

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117017/1/cpt196235599.pd

Nontobacco sources of cotinine in the urine of nonsmokers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109948/1/cptclpt199551.pd

Opioid Modulation of Oxytocin Release

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97182/1/0091270010361256.pd

AUDITORIALLY EVOKED RESPONSES: A Tool for Assessing the Patient's Ability to Hear during Various States of Consciousness

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66273/1/j.1399-6576.1966.tb01117.x.pd

Effects of tobacco smoking and abstinence on middle latency auditory evoked potentials

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109987/1/cptclpt199853.pd

Some cardiovascular effects of marihuana smoking in normal volunteers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117026/1/cpt1971125762.pd

Gas chromatography mass spectrometry assay for ketamine and its metabolites in plasma

A highly sensitive and specific method for quantitation of ketamine and two of its metabolites found in monkey, dog and human plasma was developed using a gas chromatography selected ion monitoring assay operated in both electron impact and chemical ionization modes. This technique yields excellent precision, reproducibility and accuracy. From 1 ng to 3 μg of ketamine or its metabolites in 1 ml of plasma can be detected. The technique of electron capture gas chromatography is compared. All three assays were found to be quite useful but the gas chromatography mass spectrometry techniques were more specific.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144691/1/bms1200040508.pd

Effects of urine acidification on plasma and urine phencyclidine levels in overdosage

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117118/1/cpt1977224421.pd

ELEVATION IN RAT BRAIN HISTAMINE CONTENT AFTER FOCUSED MICROWAVE IRRADIATION 1

—Microwave irradiation focused on the head of small rodents is now widely used as a means of more accurately measuring acetylcholine, choline, cyclic AMP, and several other important brain constituents. Because of its probable neurotransmitter role and rapid turnover, a similar approach was taken to study brain histamine. Histamine was measured by a modified radio-enzymatic method and was found to be nearly tripled in brains from microwave treated rats, compared to decapitation controls (124 vs 42 ng/g). Possible explanations include a microwave-induced inactivation of histamine breakdown, a microwave-induced redistribution of previously unmeasured histamine, and microwave-induced histidine decarboxylation. Brain histamine remained unchanged up to 30 min after decapitation and microwave heated brains from decapitated rats also had elevated histamine levels, indicating that brain histamine levels in decapitated rats do not represent the remainder of a rapidly depleting pool. No evidence for previously unmeasured histamine was found. Furthermore, microwave irradiation did not enhance the formation of [ 3 H]histamine after intraventricular [ 3 H]histidine administration, indicating a lack of microwave-induced histidine decarboxylation. It is concluded that the elevation in rat brain histamine after focused microwave irradiation is probably not artifactual, although the mechanism responsible for this phenomenon remains obscure.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65663/1/j.1471-4159.1977.tb09609.x.pd

Drugs and developing brain : A. Vernadakis and N. Weiner (Editors). (Plenum Press, New York, 1974, 537 p., $22.50)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22974/1/0000541.pd