Relación entre la percepción de padres y cuidadores sobre los factores que inciden en las actividades cotidianas que favorecen el desarrollo sociocognitivo de sus hijos

117 páginasThe socio-cognitive development of boys and girls has been the subject of study for many years, since it is of great interest to predict future problems, understand the learning process and individual abilities to respond to the environment. However, studies have placed too much emphasis on psychometric tests that sometimes ignore the social context of the human being in its uniqueness. For this reason, this study aimed to establish the relationships between the perception of parents and caregivers about the factors that influence their children's development and the frequency with which they report daily activities at home. We worked with a sample of 371 parents and caregivers whose children attend primary schools in four district schools in the town of San Cristóbal Sur. A quantitative approach of exploratory scope and a non-experimental design were used. For data collection, a structured survey was used based on Profamilia's National Demographic and Health Survey (ENDS) (2010), as well as the Colombian Longitudinal Survey (ELCA) and the Stanford Project on Adaptation and Resilience in Children (SPARK).El desarrollo sociocognitivo de los niños y niñas ha sido objeto de estudio durante muchos años, ya que es de gran interés para predecir problemas futuros, comprender el proceso de aprendizaje y las capacidades individuales para responder al entorno. Sin embargo, los estudios han puesto demasiado énfasis en pruebas psicométricas que, en ocasiones, pasan por alto el contexto social del ser humano en su singularidad. Por esta razón, este estudio se propuso establecer las relaciones entre la percepción de los padres y cuidadores sobre los factores que influyen en el desarrollo de sus hijos y la frecuencia con la que reportan las actividades cotidianas en el hogar. Se trabajó con una muestra de 371 padres y cuidadores cuyos hijos asisten a escuelas primarias en cuatro colegios distritales de la Localidad de San Cristóbal Sur. Se utilizó un enfoque cuantitativo de alcance exploratorio y un diseño no experimental. Para la recolección de datos, se empleó una encuesta estructurada basada en la Encuesta Nacional de Demografía y Salud (ENDS) de Profamilia (2010), así como en la Encuesta Longitudinal Colombiana (ELCA) y el Proyecto Stanford sobre Adaptación y Resiliencia en Niños (SPARK). Estos instrumentos permitieron identificar la percepción de los padres en relación con factores sociodemográficos, pautas de crianza y actividades en el hogar que influyen en el desarrollo de sus hijos.Maestría en Psicología de la Salud y la DiscapacidadMagíster en Psicología de la Salud y la Discapacida

Reflexiones para optimizar el triaje en cirugía

Introducción: La categorización de las urgencias quirúrgicas es una necesidad en razón al continuo desbalance entre la oferta y la demanda de servicios quirúrgicos en la mayoría de las instituciones donde se encuentra habilitada la prestación del servicio. Hay abordajes en el tema, con estrategias de priorización de los casos quirúrgicos, que consideran escalas y flujogramas, pero su ausente validez externa y las particularidades de las instituciones y aseguradores, han limitado una generalización de los resultados. Métodos: Se efectúa una conceptualización del triaje de las urgencias quirúrgicas con planteamientos críticos y reflexivos soportados en la evidencia. Se identifican, asimismo, las posibles oportunidades para la investigación. Discusión: Los beneficios potenciales de un triaje quirúrgico en situaciones de urgencia, son extensivos a todos los actores del sistema de salud, disminuyen la posibilidad de desenlaces y repercusiones económicas negativas para las instituciones y los aseguradores. La teoría de las colas ofrece el soporte para un entendimiento del tema y contribuye en las soluciones. Su adopción es escasa como parte de una estrategia local de priorización quirúrgica en un contexto de urgencia. Conclusión: La creación de estrategias que establezcan el triaje para el paciente con una urgencia quirúrgica están influenciadas por la participación continua y efectiva de los actores involucrados en el proceso y en su impacto en los desenlaces clínicos

Porous Titanium surfaces to control bacteria growth: mechanical properties and sulfonated polyetheretherketone coating as antibiofounling approaches

Here, titanium porous substrates were fabricated by a space holder technique. The relationship between microstructural characteristics (pore equivalent diameter, mean free-path between pores, roughness and contact surface), mechanical properties (Young’s modulus, yield strength and dynamic micro-hardness) and bacterial behavior are discussed. The bacterial strains evaluated are often found on dental implants: Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. The colony-forming units increased with the size of the spacer for both types of studied strains. An antibiofouling synthetic coating based on a sulfonated polyetheretherketone polymer revealed an effective chemical surface modification for inhibiting MRSA adhesion and growth. These findings collectively suggest that porous titanium implants designed with a pore size of 100–200 µm can be considered most suitable, assuring the best biomechanical and bifunctional anti-bacterial properties.University of Seville VI Plan Propio de Investigación y Transferencia—US 2018, I.3A

Notch Signaling Pathway Is Activated in Motoneurons of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. Notch signaling is a cell-cell communication system well known as a master regulator of neural development, but also with important roles in the adult central nervous system. Aberrant Notch function is associated with several developmental neurological disorders; however, the potential implication of the Notch pathway in SMA pathogenesis has not been studied yet. We report here that SMN deficiency, induced in the astroglioma cell line U87MG after lentiviral transduction with a shSMN construct, was associated with an increase in the expression of the main components of Notch signaling pathway, namely its ligands, Jagged1 and Delta1, the Notch receptor and its active intracellular form (NICD). In the SMNΔ7 mouse model of SMA we also found increased astrocyte processes positive for Jagged1 and Delta1 in intimate contact with lumbar spinal cord motoneurons. In these motoneurons an increased Notch signaling was found, as denoted by increased NICD levels and reduced expression of the proneural gene neurogenin 3, whose transcription is negatively regulated by Notch. Together, these findings may be relevant to understand some pathologic attributes of SMA motoneurons.This work was supported by grants from Fundación Genoma España, GENAME to JL, LT and RMS, and from Instituto de Salud Carlos III-Fondo de Investigaciones Sanitarias (PI11/01047) to RMS. AG holds a postdoctoral contract from Genoma España. VC-M and AC-R have been supported by a predoctoral fellowship from “Govern de les Illes Balears, Conselleria d’Educació, Cultura i Universitats” under a program of joint financing with the European Social Fund

The effect of grit on students’ work-engagement in surgery: A cross-sectional study

Introduction:Determination (grit) is a desirable personality trait in medical students for favorable academic performance. Commitment to work is a desired competence in undergraduate teaching-learning processes. The effect of the determination in the commitment to the work of the students is evaluated during their rotation. Methods: Students rated their determination on the Short Grit Scale (GSS) and their commitment to work on the Utrecht Work. Engagement Scale (UWES17-S). Through a mixed effect linear regression analysis, the relationships of the previous variables were established. Results: 327 students from ten medical schools were included. The GSS score was 2.96 ± 0.58 (1-5) and the UWES-S17 score was 3.94 ± 0.85 (range 2.4–7.0). In the fixed model, the effect of the determination on the students’ commitment to work was not significant (b = 0.04; 95% CI: -0.11; 0.19, neither in the random model that explored the interaction by medical school (b = 0.02; 95% CI: 0.0044; – 0.15). The determination did not influence the commitment to the work of the students. Conclusions: No significant effect of determination was found on student work commitment during rotation in the general surgery course. Other aspects such as context and social interaction, should be explored

Hydrothermal extraction of ulvans from Ulva spp. in a biorefinery approach

A simple cascade process based on the hydrothermal fractionation of Ulva spp. biomass was proposed. Considering the overall extraction yields (50 %), ulvan recovery (23 %), and ulvan composition, structural, mechanical and cytotoxic properties, the selected optimal final heating temperature was 160 °C. Ethanol precipitation provided the highest ulvan recovery yields but choline chloride precipitated ulvans showed stronger mechanical properties, G´ moduli 1.5·104 Pa and 3·104 Pa for ethanol and for choline chloride, respectively. Both products were safe on NCTC 929 mouse fibroblasts and after a cooling stage, formed films without requiring any additives. From the ulvan-free liquid fraction, one product with 43 % (wt, d.b.) phenolics and moderate antiradical properties and a byproduct containing nutrients and minerals were separated. The methane potential of the corresponding residual solids was influenced by the hydrothermal heating temperature and was doubled compared to than for the untreated seaweed biomass (60 mL/g VS). This scheme could be also applied to the wet algal biomass, in a chemical free alternative to provide ready to use ulvan biopolymers, bioactives, nutrients, salts and biogas, conforming a biorefinery approach.Agencia Estatal de Investigación | Ref. PID2021-124017OB-I00Agencia Estatal de Investigación | Ref. PID2020-117805RB-I00Xunta de Galicia | Ref. ED431C 2022/08Xunta de Galicia | Ref. ED481D-2022/018Xunta de Galicia | Ref. ED431C 2021/55Agencia Estatal de Investigación | Ref. RYC2018-024454-IXunta de Galicia | Ref. ED431F 2020/01Universidade de Vigo/CISU

Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study

Biomarkers associated with dietary fibre intake, as complements to traditional dietary assessment tools, may improve the understanding of its role in human health. Our aim was to discover metabolite biomarkers related to dietary fibre intake and investigate their association with cardiometabolic risk factors. We used data and samples from the Danish Diet Cancer and Health Next Generation (DCH-NG) MAX-study, a one-year observational study with evaluations at baseline, six and 12 months (n = 624, 55% female, mean age: 43 years, 1353 observations). Direct associations between fibre intake and plasma concentrations of 2,6-dihydroxybenzoic acid (2,6-DHBA) and indolepropionic acid were observed at the three time-points. Both metabolites showed an intraclass-correlation coefficient (ICC) > 0.50 and were associated with the self-reported intake of wholegrain cereals, and of fruits and vegetables, respectively. Other metabolites associated with dietary fibre intake were linolenoyl carnitine, 2-aminophenol, 3,4-DHBA, and proline betaine. Based on the metabolites associated with dietary fibre intake we calculated predicted values of fibre intake using a multivariate, machine-learning algorithm. Metabolomics-based predicted fibre, but not self-reported fibre values, showed negative associations with cardiometabolic risk factors (i.e. high sensitivity C-reactive protein, systolic and diastolic blood pressure, all FDR-adjusted p-values <0.05). Furthermore, different correlations with gut microbiota composition were observed. In conclusion, 2,6-DHBA and indolepropionic acid in plasma may better link dietary fibre intake with its metabolic effects than self-reported values. These metabolites may represent a novel class of biomarkers reflecting both dietary exposure and host and/or gut microbiota characteristics providing a read-out that is differentially related to cardiometabolic risk

Hemorragia anteparto asociada a placenta succenturiata. Reporte de un caso.

Introduction: placenta succenturiata is a morphological abnormality of the placenta that can result in significant morbidity and mortality for both the fetus and the mother. Aim to describe a clinical case of antepartum hemorrhage associated with placenta succenturiata. Materials and methods: a retrospective descriptive study, clinical case presentation, informed consent of the patient to have access to the clinical history and use of images corresponding to the present investigation. Clinical case: the case of a pregnant woman of 33 weeks, who enters the emergency area, with hemorrhage of the third trimester, was observed in the ultrasound, presence of a lobe that reaches the level of the internal cervical orifice, being confused with placenta previa, patient was stable and under observation, with continuous fetal monitoring, until complete lung maturation was obtained, later I present pain and bleeding before delivery so it was operated surgically by cesarean operation where the presence of succenturiado lobe in the placenta is confirmed. Both developments were favourable. Discussion: The present article demonstrates, a rare variety of placental malformation that causes multiple complications and belongs to the differential of other pathologies that cause third trimester bleeding, being associated with placenta previa, so, we must keep in mind the placenta succenturiata as a cause of bleeding in the third trimester, also take into account that in the postpartum period is cause of retention of a placental portion and can cause bleeding or infection. Conclusions: The placenta succenturiata is an abnormality of rare presentation, which is part of the differential diagnosis of haemorrhages before delivery and must be diagnosed in the prenatal period, so that prenatal control and care of the birth can be performed properly, in addition to giving guidance to the patient and her family. Caesarean delivery is recommended in these cases, with surgical approach and type of incision of choice, according to comorbidities and clinical status of the patient.Introducción: La placenta succenturiata es una anomalía morfológica de la placenta que puede resultar en morbilidad y mortalidad significativas tanto para el feto como para la madre. Objetivo: describir un caso clínico de hemorragia anteparto asociado a placenta succenturiata. &nbsp; Materiales y métodos: se realizó un estudio descriptivo retrospectivo, presentación de caso clínico, se obtuvo consentimiento informado &nbsp;de &nbsp;paciente para tener acceso a la historia clínica y uso de imágenes correspondientes a la presente investigación. Caso clínico: &nbsp;se presenta el caso de una gestante de 33 semanas, que ingresa al area de emergencias, con hemorragia del tercer trimestre, en la ecografía se observó, &nbsp;presencia de un &nbsp;lóbulo que alcanza el &nbsp;nivel del orificio cervical interno, confundiéndose con placenta previa, &nbsp;paciente se encontraba &nbsp;estable y en observación, con monitorización fetal continua, &nbsp;hasta obtener maduración pulmonar completa, posteriormente presento dolor y sangrado ante parto por lo que fue intervenida quirúrgicamente mediante operación cesárea donde se constata la presencia de lóbulo succenturiado en placenta. La evolución de ambos fue favorable. Discusión: El presente artículo demuestra, &nbsp;una rara variedad de malformación placentaria que provoca múltiples complicaciones y pertenece al diferencial de otras patologías que provocan hemorragia del tercer trimestre, pudiendo estar asociadas con placenta previa, por lo que, &nbsp;hay que tener presente la placenta succenturiata como una causa de hemorragia del tercer trimestre, además tener en consideración que en el periodo postparto &nbsp;es causa de retención de una porción placentaria y&nbsp; puede ocasionar hemorragia o infección. Conclusiones: La placenta succenturiata es una anomalía de rara presentación, que forma parte del diagnóstico diferencial de las hemorragias ante parto y que debe ser diagnosticada en el periodo prenatal, para poder así, realizar un control prenatal y atención del parto de forma adecuada, además de dar una orientación a la paciente y su familia. Se recomienda en estos casos el parto por cesárea, con abordaje quirúrgico y tipo de incisión a elección, de acuerdo a comorbilidades y estado clínico de paciente

A longitudinal prospective study of active tuberculosis in a Western Europe setting : insights and findings

This study investigates the potential of inflammatory parameters (IP), symptoms, and patient-related outcome measurements as biomarkers of severity and their ability to predict tuberculosis (TB) evolution. People with TB were included prospectively in the Stage-TB study conducted at five clinical sites in Barcelona (Spain) between April 2018 and December 2021. Data on demographics, epidemiology, clinical features, microbiology, and Sanit George Respiratory Questionnaire (SGRQ) and Kessler-10 as Health-Related Quality of Life (HRQoL) were collected at three time points during treatment. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil/lymphocyte, and monocyte/lymphocyte ratios (NLR and MLR), complement factors C3, C4, and cH50, clinical and microbiological data, and HRQoL questionnaires were assessed at baseline, 2 months, and 6 months. Their ability to predict sputum culture conversion (SCC) and symptom presence after 2 months of treatment was also analysed. The study included 81 adults and 13 children with TB. The CRP, ESR, NLR, and MLR values, as well as the presence of symptoms, decreased significantly over time in both groups. Higher IP levels at baseline were associated with greater bacillary load and persistent symptoms. Clinical severity at baseline predicted a delayed SCC. Kessler-10 improved during follow-up, but self-reported lung impairment (SGRQ) persisted in all individuals after 6 months. IP levels may indicate disease severity, and sustained high levels are linked to lower treatment efficacy. Baseline clinical severity is the best predictor of SCC. Implementing health strategies to evaluate lung function and mental health throughout the disease process may be crucial for individuals with TB. The online version contains supplementary material available at 10.1007/s15010-024-02184-2