Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Laparoscopic gastrostomy under awake thoracic epidural anesthesia: A successful experience

General anesthesia is the first choice as an anesthesia method particularly for abdominal operations. However, because neuromuscular blockade induced during general anesthesia will increase atelectasis in a patient with pulmonary disease, it will also increase postoperative ventilator dependence, which will be even more apparent in cases of chronic obstructive pulmonary disease (COPD) that pose a risk, particularly for postoperative complications. Herein, thoracic epidural anesthesia (TEA) was found to be a better option for our patient with severe COPD and stage IV lung cancer, as it provided sufficient anesthesia and better postoperative care for laparoscopic gastrostomy

Effects of Addition of Preoperative Intravenous Ibuprofen to Pregabalin on Postoperative Pain in Posterior Lumbar Interbody Fusion Surgery

Objective. Ibuprofen and pregabalin both have independent positive effects on postoperative pain. The aim of the study is researching effect of 800 mg i.v. ibuprofen in addition to preoperative single dose pregabalin on postoperative analgesia and morphine consumption in posterior lumbar interbody fusion surgery. Materials and Methods. 42 adult ASA I-II physical status patients received 150 mg oral pregabalin 1 hour before surgery. Patients received either 250 ml saline with 800 mg i.v. ibuprofen or saline without ibuprofen 30 minutes prior to the surgery. Postoperative analgesia was obtained by morphine patient controlled analgesia (PCA) and 1 g i.v. paracetamol every six hours. PCA morphine consumption was recorded and postoperative pain was evaluated by Visual Analog Scale (VAS) in postoperative recovery room, at the 1st, 2nd, 4th, 8th, 12th, 24th, 36th, and 48th hours. Results. Postoperative pain was significantly lower in ibuprofen group in recovery room, at the 1st, 2nd, 36th, and 48th hours. Total morphine consumption was lower in ibuprofen group at the 2nd, 4th, 8th, 12th, and 48th hours. Conclusions. Multimodal analgesia with preoperative ibuprofen added to preoperative pregabalin safely decreases postoperative pain and total morphine consumption in patients having posterior lumbar interbody fusion surgery, without increasing incidences of bleeding or other side effects

Non-cardiogenic pleural effusion after amlodipine intoxication and hyperinsulinemic therapy

We report a patient with amlodipine intoxication who presented to hospital 30 hours after suicidal intake of the drug. Admitted to the intensive care unit, the patient had profound hypotension and need for fluid replacement and infusion of dopamine and noradrenaline. The patient was also administered insulin and calcium gluconate. In addition to profound hypotension, massive non-cardiogenic pleural effusion also complicated the clinical picture. Bilateral pleurocans were placed and non-invasive ventilation was administered in continuous positive airway pressure (CPAP) mode. Hyperinsulinemic euglycemic therapy was also applied. Following the onset of insulin therapy mean blood pressure increased and need for vasopressors was reduced. Possible positive inotropic action of insulin therapy in this patient suffering calcium channel blocker intoxication is in accordance with previous reports. It has been suggested that hyperinsulinemic euglycemic therapy may be considered as a first-line therapy in amlodipine intoxication. [Med-Science 2016; 5(4.000): 1024-6

Rett syndrome and anaesthetic management: a case report

Rett syndrome is a progressive neurological disorder that occurs only in females and it manifests with mental retardation, seizures, movement disorders, autistic behavior, and abnormal breathing. A 4.5-year-old female child with Rett syndome underwent dental restoration under sedoanalgesia. Her physical examination was normal except for sterotyped movements. We recommend that anesthesiologists should have knowledge about this disorders characteristics, complications, potential associated problems, and important aspects of anesthetic drug selection. [Med-Science 2017; 6(1.000): 122-4

The effect of intravenous administration of ondansetron on analgesia time of caudal block in circumcision cases: A randomized controlled trial

We investigate whether there was any effect of intravenous ondansetron administered for postoperative nausea vomiting prophylaxis on the duration of caudal block action in patients who undergo circumcision surgery. 66 ASA III patients aged 4 to 10 and scheduled for circumcision surgery were included in this prospective, randomized controlled study. We administered 0.1 mg/kg ondansetron IV to Group Ondansetron patients before caudal block and same amount of serum physiologic for Group Control patients. After anesthesia induction caudal block with 1 ml/kg 0.25% bupivacaine administered. We evaluated postoperative analgesia durations in each group. There were no difference between groups for number of patients which were painless for first 4 hours and 8 hours, total analgesic requirements for first 24 hours, total time for first analgesic requirements. We concluded that iv ondansetron given at 0.1 mg/kg dose before caudal block with bupivacaine can be used safely without a significant effect on the duration of block-induced analgesia. [Med-Science 2018; 7(2.000): 303-5

Acetamiprid Poisoning Followed By Prolonged Muscle Weakness

Neonicotinoids, a new insecticide group, are considered to possess a low toxicity profile for humans. In this paper, a 41-year-old female patient who was treated for prolonged muscle weakness at an intensive care unit for 22 days and discharged without any sequela following oral acetamiprid intake for suicidal purposes is reported. After developing a clinical picture similar to the intermediate syndrome seen in organophosphate poisoning, the patient recovered with the help of symptomatic and supportive treatment