Mortality and morbidity in newborns of insulin dependent diabetic mothers

A retrospective study has been done on records of 63 newborns, born of insulin dependent diabetic mothers between 1964 and 1974, when a team consisting of an obstetrician, a diabetologist and a paediatrician systematically controlled the maternal diabetes during pregnancy and also took care of the newborns. Perinatal mortality was 11.1%, foetal mortality was 7.9% and early neonatal mortality was 3.2%. The percentage of congenital malformations in our population of living newborns of insulin dependent diabetic mothers was 3.2%. Respiratory distress occurred in 17.4% of the children.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Colonic stenoses after necrotizing enterocolitis

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EVALUATION ECHOGRAPHIQUE DES ANASARQUES FOETO-PLACENTAIRES NON IMMUNITAIRES. UNE SERIE DE 24 CAS

24 cases of non-immune feto-placental hydrops which were diagnosed by ultrasonography are presented. The precise etiology was found in 21 of the cases using chromosome analyses, radiological assessments and carefully conducted post mortem examinations. The cause of maternal in 3 cases and due to fetal pathology in 18 cases, of which 5 were due to chromosome abnormalities. Three recessive autosomal syndromes, 9 malformations, in particular cardiac malformations, and one twin pregnancy with transfusion from one fetus to the other were diagnosed. These features, which can be compared with those already in the literature, show that most of these cases of hydrops are due to genetic fetal defects and demonstrate how important it is to carry out chromosome analyses and systematic anatomo-pathological investigations. The results of these tests will indicate the way doctors should look after the mother during pregnancy and how to deliver these mothers in subsequent pregnancies.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Evaluation of a prospective protocol for treatment of neonatal necrotizing enterocolitis

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DIAGNOSTIC ANTENATAL DES MALFORMATIONS DU SYSTEME NERVEUX CENTRAL

Since the very start of using ultrasound to monitor pregnancy the information that the obstetrician has obtained from it has been great. Measuring the fetus (biparietal diameters, rump-crown length, etc.) makes it possible to check development of the fetus in the uterus, as well as to see the various organs and their position and internal structure. Real time pictures make it possible to visualise the organs precisely from the point of view of their position and their internal structures. We report 12 cases of malformations of the central nervous system which were diagnosed in utero and we point out the value of early diagnosis in pregnancy. The 12 cases we found included four of hydrocephaly, one cyst of the choroid plexus, one hydrencephaly, two cases of holoprosencephaly and four cases of anencephaly. Since these malformations may be part of generalised malformations it is important to search for them by ultrasound as well as by caryotyping and estimation of alpha-fetoprotein levels.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Studies on hypoglycaemia in small-for-dates newborns

Fasting blood sugar, lactate/pyruvate ratio, blood FFA level, and response to intravenous glucagon (300 μg./kg.) were determined on the first, third, and fifth day of life in 34 children of low birthweight for gestational age (<expected weight minus 2 SD), and in 31 normal infants. There was considerable overlap of the average results of both groups for all these values, and no statistical differences were noted. Hypoglycaemia was found in 10 of 28 term children of low birthweights and occurred most often during the first 24 hours of life. Intravenous glucagon induced a satisfactory rise in blood glucose at all fasting blood glucose levels. It is concluded that depletion of hepatic glycogen stores plays no significant role in the genesis of hypoglycaemia in 'small-for-dates' infants.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Serum thyrotropin determination at the fifth day of life as a screening procedure for congenital hypothyroidism

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Adverse effect of amniofetography on fetal thyroid function

Amniofetography is a valuable tool for the diagnosis of fetal malformations. This technique is being used routinely in pregnancies carrying a high risk of external fetal malformations. There are very few published data concerning the effect of radiopaque dyes, containing large amounts of iodide, on fetal thyroid function. We have performed serial determinations of serum thyrotropin and thyroxine in seven newborn infants to assess the effect of amniofetography on fetal thyroid function. This work demonstrates that amniofetography induces a transient impairment of fetal thyroid function. © 1976.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Clinical aspects and systematic screening for congenital hypothyroidism in the newborn

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Transient hypothyroidism in premature infants in intensive care

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