Downsizing a Great Observatory: Reinventing Spitzer in the Warm Mission

The Spitzer Space Telescope transitioned from the cryogen mission to the IRAC warm mission during 2009. This transition involved changing several areas of operations in order to cut the mission annual operating costs to 1/3 of the cryogen mission amount. In spite of this substantial cut back, Spitzer continues to have one of the highest science return per dollar ratio of any of NASA's extended missions. This paper will describe the major operational changes made for the warm mission and how they affect the science return. The paper will give several measures showing that warm Spitzer continues as one of the most scientifically productive mission in NASA's portfolio. This work was performed at the California Institute of Technology under contract to the National Aeronautics and Space Administration

The Spitzer science operations system: how well are we really doing?

The Spitzer Space Telescope was successfully launched on August 25th, 2003. After a 90 day In Orbit Checkout and Science Verification period, Spitzer began its five and one half year mission of science observations at wavelengths ranging from 3.6 to 160 microns. Early results from Spitzer show the observatory performing exceptionally well, meeting performance requirements in all areas. The California Institute of Technology is the home for the Spitzer Science Center (SSC). The SSC is responsible for selecting observing proposals, providing technical support to the science community, performing mission planning and science observation scheduling, instrument calibration and performance monitoring during operations, and production of archival quality data products. This paper will address the performance of the Spitzer science operations for the first nine months of the mission, covering science efficiency, science planning and scheduling metrics, data through-put and processing durations, system improvements, and science community interest. This work was performed at the California Institute of Technology under contract to the National Aeronautics and Space Administration

Spitzer's model for dealing with the end of the cryogenic mission

The Spitzer Space Telescope is a cryogenically cooled telescope operating three instruments in wavelengths ranging from 3.6 microns to 160 microns. Spitzer, the last of NASA's Great Observatories, was launched in August 2003 and has been operating for 4.5 years of an expected 5.5 year cryogen mission. The highly efficient Observatory has provided NASA and the science community with unprecedented data on galaxies, star formation, interstellar medium, exoplanets, and other fundamental astronomical topics. Spitzer's helium lifetime is predicted to end on April 18, 2009, with an uncertainty of +/- 3 months. Planning for this cryogen end involves many diverse areas of the project and is complicated due to the uncertainty in the actual date of helium depletion. This paper will describe how the Spitzer team is accommodating the unknown end date in the areas of observation selection, planning and scheduling, spacecraft and instrument monitoring, data processing and archiving, and finally, budgeting and staffing. This work was performed at the California Institute of Technology under contract to the National Aeronautics and Space Administration

Ongoing evolution of proposal reviews in the Spitzer warm mission

The Spitzer Space Telescope is executing the seventh year of extended warm mission science. The cryogenic mission operated from 2003 to 2009. The observing proposal review process has evolved from large, week-long, in-person meetings during the cryogenic mission to the introduction of panel telecon reviews in the warm mission. Further compression of the schedule and budget for the proposal solicitation and selection process led to additional changes in 2014. Large proposals are still reviewed at an in-person meeting but smaller proposals are no longer discussed by a topical science panel. This hybrid process, involving an in-person committee for the larger proposals and strictly external reviewers for the smaller proposals, has been successfully implemented through two observing cycles. While people like the idea of not having to travel to a review it is still the consensus opinion, in our discussions with the community, that the in-person review panel discussions provide the most satisfying result. We continue to use in-person reviews for awarding greater than 90% of the observing time

Ongoing evolution of proposal reviews in the Spitzer warm mission

The Spitzer Space Telescope is executing the seventh year of extended warm mission science. The cryogenic mission operated from 2003 to 2009. The observing proposal review process has evolved from large, week-long, in-person meetings during the cryogenic mission to the introduction of panel telecon reviews in the warm mission. Further compression of the schedule and budget for the proposal solicitation and selection process led to additional changes in 2014. Large proposals are still reviewed at an in-person meeting but smaller proposals are no longer discussed by a topical science panel. This hybrid process, involving an in-person committee for the larger proposals and strictly external reviewers for the smaller proposals, has been successfully implemented through two observing cycles. While people like the idea of not having to travel to a review it is still the consensus opinion, in our discussions with the community, that the in-person review panel discussions provide the most satisfying result. We continue to use in-person reviews for awarding greater than 90% of the observing time

NuSTAR observatory science operations: on-orbit acclimation

The Nuclear Spectroscopic Telescope Array (NuSTAR) is the first focusing high energy (3-79 keV) X-ray observatory. The NuSTAR project is led by Caltech, which hosts the Science Operations Center (SOC), with mission operations managed by UCB Space Sciences Laboratory. We present an overview of NuSTAR science operations and describe the on-orbit performance of the observatory. The SOC is enhancing science operations to serve the community with a guest observing program beginning in 2015. We present some of the challenges and approaches taken by the SOC to operating a full service space observatory that maximizes the scientific return from the mission

Neutrophil GM-CSF receptor dynamics in acute lung injury.

GM-CSF is important in regulating acute, persistent neutrophilic inflammation in certain settings, including lung injury. Ligand binding induces rapid internalization of the GM-CSF receptor (GM-CSFRα) complex, a process essential for signaling. Whereas GM-CSF controls many aspects of neutrophil biology, regulation of GM-CSFRα expression is poorly understood, particularly the role of GM-CSFRα in ligand clearance and whether signaling is sustained despite major down-regulation of GM-CSFRα surface expression. We established a quantitative assay of GM-CSFRα surface expression and used this, together with selective anti-GM-CSFR antibodies, to define GM-CSFRα kinetics in human neutrophils, and in murine blood and alveolar neutrophils in a lung injury model. Despite rapid sustained ligand-induced GM-CSFRα loss from the neutrophil surface, which persisted even following ligand removal, pro-survival effects of GM-CSF required ongoing ligand-receptor interaction. Neutrophils recruited to the lungs following LPS challenge showed initially high mGM-CSFRα expression, which along with mGM-CSFRβ declined over 24 hr; this was associated with a transient increase in bronchoalveolar lavage fluid (BALF) mGM-CSF concentration. Treating mice in an LPS challenge model with CAM-3003, an anti-mGM-CSFRα mAb, inhibited inflammatory cell influx into the lung and maintained the level of BALF mGM-CSF. Consistent with neutrophil consumption of GM-CSF, human neutrophils depleted exogenous GM-CSF, independent of protease activity. These data show that loss of membrane GM-CSFRα following GM-CSF exposure does not preclude sustained GM-CSF/GM-CSFRα signaling and that this receptor plays a key role in ligand clearance. Hence neutrophilic activation via GM-CSFR may play an important role in neutrophilic lung inflammation even in the absence of high GM-CSF levels or GM-CSFRα expression