ANALYSIS OF THE RESULTS OF SURGICAL PROCEDURES ADVISABLE FOR CHRONIC PANCREATITIS WITH THE PREDOMINANT LESION OF THE PANCREATIC HEAD

Recently, studies comparing various variants of operations to establish the optimal method of surgical treatment for chronic pancreatitis with pancreatic head lesions from the point of view of evidence-based medicine have been carried out in the world. However, these comparative studies do not take into account differences in the clinical and morphological forms of the disease, in particular, chronic pancreatitis with a predominant and isolated lesion of the head. Subtotal resection of the pancreatic head with proximal pancreatojejunostomy, suitable for an isolated lesion of the head, does not solve all the problems of chronic pancreatitis with a predominant lesion of the head. In this case, the violation of the outflow of pancreatic juice along the pathologically changed main pancreatic duct from the left half of the gland is not eliminated. It is impossible to unambiguously support the hypothesis of the feasibility of performing subtotal resection of the pancreatic head with proximal pancreatojejunostomy in chronic pancreatitis with a predominant lesion of the head with a uniformly expanded main pancreatic duct. With this form of chronic pancreatitis, cicatricial strictures can form in the main pancreatic duct, which can lead to ductal hypertension and serve as an indication for reoperation. The feasibility of using Beger operation in chronic pancreatitis with a predominant lesion of the head is doubtful, since the intersection of the isthmus and the need for a T-shaped longitudinal pancreatojejunostomy makes this intervention technically difficult and unsafe. Based on the studies performed, it is impossible to say with certainty about the reliable advantages of one type of operations over another. To obtain reliable results, it’s necessary to conduct evidence-based studies comparing subtotal resection of the pancreatic head with longitudinal pancreatojejunostomy with other types of interventions only for chronic pancreatitis with a predominant head lesion, excluding from the study patients with chronic pancreatitis with isolated head lesion

ПРИМЕНЕНИЕ МНОГОКАНАЛЬНОГО ПНЕВМОМЕТРИЧЕСКОГО ЗОНДА ДЛЯ ИССЛЕДОВАНИЯ ПРОФИЛЯ СКОРОСТИ ТЕПЛОНОСИТЕЛЯ В МОДЕЛЯХ ТОПЛИВНЫХ КАССЕТ ЯДЕРНЫХ РЕАКТОРОВ

Development of heat and mass transfer intensifiers is a major engineering task in the design of new and modernization of existing fuel assemblies. These devices create lateral mass flow of coolant. Design of intensifiers affects both the coolant mixing and the hydraulic resistance. The aim of this work is to develop a methodology of measuring coolant local velocity in the fuel assembly models with different mixing grids. To solve the problems was manufactured and calibrated multihole pressure probe. The air flow velocity measuring method with multihole pressure probe was used in the experimental studies on the coolant local hydrodynamics in fuel assemblies with mixing grids. Analysis of the coolant lateral velocity vector fields allowed to study the formation of the secondary vortex flows behind the mixing grids, and to determine the basic laws of coolant flow in experimental models. Quantitative data on the coolant flow velocity distribution obtained with a multihole pressure probe make possible to determine the magnitude of the flow lateral velocities in fuel rod gaps, as well as to determine the distance at which damping occurs during mixing. Разработка интенсификаторов теплои массообмена является важной инженерной задачей при конструировании новых и модернизации существующих тепловыделяющих сборок (ТВС). Такие устройства создают направленный поперечный основному потоку перенос массы теплоносителя. В то же время конструкция интенсификаторов влияет как на перемешивание теплоносителя, так и на гидравлическое сопротивление. Целью работы являлась разработка методики измерения локальных векторов скорости теплоносителя в моделях ТВС с различными перемешивающими решетками. Для решения поставленных задач был изготовлен пневмометрический пятиканальный зонд, проведена его тарировка в однородном потоке воздуха с заданной скоростью при различных углах установки зонда. По результатам тарировки получены численные значения безразмерных комплексов давления в каналах зонда и определена их зависимость от углов набегания воздушного потока. Представленная в статье методика измерения вектора скорости потока воздуха многоканальным пневмометрическим зондом была применена в экспериментальных исследованиях по изучению локальной гидродинамики в тепловыделяющих сборках с перемешивающими решетками. Анализ полученных векторных полей поперечной скорости теплоносителя позволил изучить формирование вторичных вихревых течений за перемешивающими решетками моделей ТВС, а также определить основные закономерности движения теплоносителя. Количественные данные о распределении всех трех проекций вектора скорости потока теплоносителя, полученные с помощью пятиканального зонда, позволили определить величины поперечных скоростей потока в межтвэльных зазорах, а также определить расстояние, на котором происходит затухание процессов перемешивания.

Conjugation of Organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and Indolo[3,2-d]benzazepines to Recombinant Human Serum Albumin: a Strategy To Enhance Cytotoxicity in Cancer Cells

Five organoruthenium complexes [RuCl(η6-arene)(L)]Cl with a modified arene ligand, namely, 4-formylphenoxyacetyl-η6-benzylamide, and L = 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines or indolo[3,2-d]benzazepines were synthesized and conjugated to recombinant human serum albumin in order to improve their drug targeting and delivery to cancer cells, and a marked increase in cytotoxicity was observed

Исследование локальной гидродинамики теплоносителя в смешанной активной зоне реактора ВВЭР

The article presents the results of experimental studies of the local hydrodynamics of the coolant flow in the mixed core of the VVER reactor, consisting of the TVSA-T and TVSA-T mod.2 fuel assemblies. Modeling of the flow of the coolant flow in the fuel rod bundle was carried out on an aerodynamic test stand. The research was carried out on a model of a fragment of a mixed core of a VVER reactor consisting of one TVSA-T segment and two segments of the TVSA-T.mod2. The flow pressure fields were measured with a five-channel pneumometric probe. The flow pressure field was converted to the direction and value of the coolant velocity vector according to the dependencies obtained during calibration. To obtain a detailed data of the flow, a characteristic cross-section area of the model was selected, including the space cross flow between fuel assemblies and four rows of fuel rods of each of the TVSA fuel assemblies. In the framework of this study the analysis of the spatial distribution of the projections of the velocity of the coolant flow was fulfilled that has made it possible to pinpoint regularities that are intrinsic to the coolant flowing around spacing, mixing and combined spacing grates of the TVSA. Also, the values of the transverse flow of the coolant caused by the flow along hydraulically nonidentical grates were determined and their localization in the longitudinal and cross sections of the experimental model was revealed. Besides, the effect of accumulation of hydrodynamic flow disturbances in the longitudinal and cross sections of the model caused by the staggered arrangement of hydraulically non-identical grates was determined. The results of the study of the coolant cross flow between fuel assemblies interaction, i.e. between the adjacent TVSA-T and TVSA-T mod.2 fuel assemblies were adopted for practical use in the JSC of “Afrikantov OKB Mechanical Engineering” for assessing the heat engineering reliability of VVER reactor cores; also, they were included in the database for verification of computational hydrodynamics programs (CFD codes) and for detailed cell-based calculation of the reactor core.В статье представлены результаты экспериментальных исследований локальной гидродинамики потока теплоносителя в смешанной активной зоне реактора ВВЭР, состоящей из ТВСА-Т и ТВСА-Т.mod.2. Моделирование процессов течения потока теплоносителя в пучке твэлов проводилось на аэродинамическом стенде. Исследования осуществлялись на модели фрагмента смешанной активной зоны реактора ВВЭР, состоящей из одного сегмента ТВСА-Т и двух ТВСА-Т.mod.2. Поля давлений потока измеряли пятиканальным пневмометрическим зондом. Поле давлений потока согласно зависимостям, полученным при тарировке, пересчитывалось в направление и величину вектора скорости теплоносителя. Для создания детальной картины течения потока была выделена характерная область поперечного сечения модели, включающая межкассетное пространство и четыре ряда твэлов каждой из топливных сборок ТВСА. В рамках реализации данного исследования проведен анализ пространственного распределения проекций скорости потока теплоносителя, который позволил выявить закономерности обтекания теплоносителем дистанционирующих, перемешивающих и комбинированных дистанционирующих решеток ТВСА, определены величины поперечных потоков теплоносителя, вызванных обтеканием гидравлически неидентичных решеток, установлена их локализация в продольном и поперечном сечениях экспериментальной модели. Кроме того, выявлен эффект накопления гидродинамических возмущений потока в продольном и поперечном сечениях модели, вызванный шахматным расположением гидравлически неидентичных решеток. Результаты исследования межкассетного взаимодействия теплоносителя между соседними ТВСА-Т и ТВСА-Т.mod.2 приняты для практического использования в АО «ОКБМ Африкантов» при оценке теплотехнической надежности активных зон реакторов ВВЭР и включены в базу данных для верификации программ вычислительной гидродинамики (CFD-кодов) и детального поячеечного расчета активной зоны реакторов

APPLICATION OF MULTIHOLE PRESSURE PROBE FOR RESEARCH OF COOLANT VELOCITY PROFILE IN NUCLEAR REACTOR FUEL ASSEMBLIES

Development of heat and mass transfer intensifiers is a major engineering task in the design of new and modernization of existing fuel assemblies. These devices create lateral mass flow of coolant. Design of intensifiers affects both the coolant mixing and the hydraulic resistance. The aim of this work is to develop a methodology of measuring coolant local velocity in the fuel assembly models with different mixing grids. To solve the problems was manufactured and calibrated multihole pressure probe. The air flow velocity measuring method with multihole pressure probe was used in the experimental studies on the coolant local hydrodynamics in fuel assemblies with mixing grids. Analysis of the coolant lateral velocity vector fields allowed to study the formation of the secondary vortex flows behind the mixing grids, and to determine the basic laws of coolant flow in experimental models. Quantitative data on the coolant flow velocity distribution obtained with a multihole pressure probe make possible to determine the magnitude of the flow lateral velocities in fuel rod gaps, as well as to determine the distance at which damping occurs during mixing

Investigation of Coolant Local Hydrodynamics in the Mixed Core of the VVER Reactor

The article presents the results of experimental studies of the local hydrodynamics of the coolant flow in the mixed core of the VVER reactor, consisting of the TVSA-T and TVSA-T mod.2 fuel assemblies. Modeling of the flow of the coolant flow in the fuel rod bundle was carried out on an aerodynamic test stand. The research was carried out on a model of a fragment of a mixed core of a VVER reactor consisting of one TVSA-T segment and two segments of the TVSA-T.mod2. The flow pressure fields were measured with a five-channel pneumometric probe. The flow pressure field was converted to the direction and value of the coolant velocity vector according to the dependencies obtained during calibration. To obtain a detailed data of the flow, a characteristic cross-section area of the model was selected, including the space cross flow between fuel assemblies and four rows of fuel rods of each of the TVSA fuel assemblies. In the framework of this study the analysis of the spatial distribution of the projections of the velocity of the coolant flow was fulfilled that has made it possible to pinpoint regularities that are intrinsic to the coolant flowing around spacing, mixing and combined spacing grates of the TVSA. Also, the values of the transverse flow of the coolant caused by the flow along hydraulically nonidentical grates were determined and their localization in the longitudinal and cross sections of the experimental model was revealed. Besides, the effect of accumulation of hydrodynamic flow disturbances in the longitudinal and cross sections of the model caused by the staggered arrangement of hydraulically non-identical grates was determined. The results of the study of the coolant cross flow between fuel assemblies interaction, i.e. between the adjacent TVSA-T and TVSA-T mod.2 fuel assemblies were adopted for practical use in the JSC of “Afrikantov OKB Mechanical Engineering” for assessing the heat engineering reliability of VVER reactor cores; also, they were included in the database for verification of computational hydrodynamics programs (CFD codes) and for detailed cell-based calculation of the reactor core