1 research outputs found
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
- Abedalthagafi Malak
- Abul-Husn Noura S.
- Acquilini Donatella
- Adams Emma L.
- Adamsara Alireza
- Adeleye Olumide
- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- Agüero Daiana
- Ahmadi Saeideh
- Aksentijevich Alexandra
- Al Harthi Fawz
- Al Mutairi Amal
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
- Alahmadey Ziab Z.
- Alaverdian Diana
- Alavere Helene
- Albader Anoud
- Albaiceta Guillermo M.
- Albakri Jehad K.
- AlBardis Hadeel
- Albeladi Maha
- Albesher Nour
- Albrich Werner
- AlDhawi Nouf
- Aleagha Afshar Etemadi
- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
- AlMalik Abdulaziz
- Almalki Faisal
- Almohammed Iman
- Almutairi Mansour
- Alotaibi Sara
- Alowayn Albandary M.
- Alqahtani Saleh
- Alqubaishi Fatimah
- Alrashed May
- Alshareef Abdulraheem
- Alsolm Ebtehal
- Alswailm Moneera
- AlZahrani Deema
- Amirsavadkouhi Ali
- Amitrano Sara
- Andolfo Immacolata
- Andretta Francesca
- Andreucci Elena
- Andrews Shea J.
- Andrews Shea J.
- Andrews Shea J.
- Anedda Federico
- Anemoli Valentina
- Anne Feng Yen-Chen
- Annis Aubrey
- Antinori Andrea
- Antoni Melania Degli
- Aprile von Hohenstaufen Kathrin
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- Armstrong Jacob
- Arning Nicolas
- Arranz Maria J.
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- Arumugam Prabhu
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- Atkinson Elizabeth G.
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- Bryant Sam
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- Butler-Laporte Guillaume
- Butler-Laporte Guillaume
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- Hegazy Mohamed A. F.
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- Ho Yuk-Lam
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- Huffman Jennifer E.
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- Khafaga Walid T.
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- King Daniel
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- Koelling Nils
- Kogevinas Manolis
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- Léonard Philippe
- Li Binglan
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- Li Rui
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- Llucià-Carol Laia
- Lo Rizzo Caterina
- Loos Ruth J. F.
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- Nguyen Jennifer P.
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- Niemi Mari E. K.
- Niemi Mari E. K.
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- O’Connell Anne Marie
- O’Donnell Christopher J.
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- Shotelersuk Vorasuk
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- Von Frenckell Christian
- Vonk Judith. M.
- Wain Louise V.
- Walker Susan
- Walters Raymond K.
- Wang Jiongming
- Wang Xueyang
- Wanying Zhu
- Warmerdam Robert
- Weiss Scott T.
- Wicks Stephen J.
- Willer Cristen
- Williams Alexander T.
- Wilson Daniel J.
- Wilson James F.
- Wolford Brooke
- Wolford Brooke
- Woolley Ann E.
- Wright John
- Wyllie David H.
- Xue Xiaoqing
- Yadav Ashish
- Yassen Amr M.
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- Zeberg Hugo
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- Zhang Miao
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- Zhou Wei
- Zhou Wei
- Zlatopolsky Menachem
- Zucchi Patrizia
- Zyndorf Marissa
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types