Architectural and town-planning reconstruction problems of the city of Voronezh

The analysis of the state of the historically developed urban district of the city of Voronezh is made. The ways of solving the identified architectural and urban problems of reconstruction of historically developed buildings are proposed. The concept of reconstruction of a territory with historical buildings along Vaytsekhovsky Street is presented

Architectural and town-planning reconstruction problems of the city of Voronezh

The analysis of the state of the historically developed urban district of the city of Voronezh is made. The ways of solving the identified architectural and urban problems of reconstruction of historically developed buildings are proposed. The concept of reconstruction of a territory with historical buildings along Vaytsekhovsky Street is presented

SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case

The article highlights the course of long-term SARS-CoV-2 infection in a patient with a secondary immunodeficiency developed with B-cell-depleting therapy of the underlying disease. Analysis of the intrapatient virus evolution revealed an inpatient S:G75A mutation that alters the 72GTNGTKR78 motif of the S-protein, with a possible role in binding to alternative cellular receptors. Therapy with a ready-made COVID-19-globulin preparation (native human immunoglobulin G (IgG) derived from the plasma of convalescent COVID-19-patients) resulted in rapid improvement of the patient’s condition, fast, and stable elimination of the virus, and passive immunization of the patient for at least 30 days. The results suggest the use of products containing neutralizing antibodies opens new prospects for treatment algorithms for patients with persistent coronavirus infection, as well as for passive immunization schemes for patients with a presumably reduced specific response to vaccination

Resonator Method for Studying Dielectric Characteristics of Сaustobiolithes

Для суб-ТГц диапазона на основе резонаторного спектрометра развита методика исследования электродинамических характеристик органических материалов – каустобиолитов. В диапазоне частот 110 ÷ 260 ГГц проведены исследования диэлектрических параметров (показателя преломления n и tanδ) порошков торфа после его СВЧ‑переработки в процессе «мягкого» пиролиза, а также срезов керна нефтесодержащей породы. Рассмотрено влияние естественной влажности на диэлектрические параметры образцов. Обсуждаются причины разброса результатов измерений, который наблюдается в указанных материалах и является их специфической особенностьюFor the sub-THz range, a method for studying the electrodynamic characteristics of organic materials – caustobiolithes-is developed on the basis of a resonator spectrometer. In the frequency range 110 ÷ 260 GHz, the dielectric parameters (refractive index n and tanδ) of peat powders after its microwave processing in the process of «soft» pyrolysis, as well as core sections of oil-containing rock, were studied. The influence of natural humidity on the dielectric parameters of the samples is considered. The reasons for the spread of measurement results, which is observed in these materials and is their specific feature, are discusse

A defined road to tracheal reconstruction: laser structuring and cell support for rapid clinic translation

Abstract One of the severe complications occurring because of the patient’s intubation is tracheal stenosis. Its incidence has significantly risen because of the COVID-19 pandemic and tends only to increase. Here, we propose an alternative to the donor trachea and synthetic prostheses—the tracheal equivalent. To form it, we applied the donor trachea samples, which were decellularized, cross-linked, and treated with laser to make wells on their surface, and inoculated them with human gingiva-derived mesenchymal stromal cells. The fabricated construct was assessed in vivo using nude (immunodeficient), immunosuppressed, and normal mice and rabbits. In comparison with the matrix ones, the tracheal equivalent samples demonstrated the thinning of the capsule, the significant vessel ingrowth into surrounding tissues, and the increase in the submucosa resorption. The developed construct was shown to be highly biocompatible and efficient in trachea restoration. These results can facilitate its clinical translation and be a base to design clinical trials. Graphical Abstrac