Extracellular Nucleic Acids in Blood of Patients with Chronic Obstructive Pulmonary Disease

The concentrations of extracellular nucleic acids and acid-soluble precursors of nucleic acids in blood of patients with different forms and severity of chronic obstructive pulmonary disease (COPD) were evaluated. The significant increase of the content of extracellular RNA and acid-soluble precursors of nucleic acids in plasma of patients with COPD was detected. The decrease of extracellular RNA in plasma of patients with COPD worsening was diagnosed. Extracellular DNA in plasma and red blood cells of patients didn’t change significantly. The article examines the mechanisms of extracellular nucleic acids increase in blood of COPD patients, studies the possible role of extracellular RNA in development of coagulation disorders in COPD patients. The further research of the role of extracellular nucleic acids and their precursors in COPD progression is require

Comparative Characteristics of Erythrocytes Charge Balance in Patients with Chronic Obstructive Pulmonary Disease

The aim of the investigation is studying of erythrocytes charge balance in patients with chronic obstructive pulmonary disease (COPD) of bronchitic and mixed types. The similar trend of change Δ pH of erythrocytes in patients with COPD was observed during the incubation of red blood cells in the range of 37-58 ˚C. The thermograms represented decreasing curve, Δ pH ranged from -0.326 to -0.453 (the average value was -0.383). During subsequent 20- minute incubation of erythrocyte suspension at 58 ˚C, two main types of thermal images, depending on the degree of respiratory failure were recorded. Possible mechanisms of the erythrocytes charge balance alterations in patients with COPD are discussed