9 research outputs found
Measurement of Photon Statistics with Live Photoreceptor Cells
We analyzed the electrophysiological response of an isolated rod
photoreceptor of Xenopus laevis under stimulation by coherent and
pseudo-thermal light sources. Using the suction electrode technique for single
cell recordings and a fiber optics setup for light delivery allowed
measurements of the major statistical characteristics of the rod response. The
results indicate differences in average responses of rod cells to coherent and
pseudo-thermal light of the same intensity and also differences in
signal-to-noise ratios and second order intensity correlation functions. These
findings should be relevant for interdisciplinary studies seeking applications
of quantum optics in biology.Comment: 6 pages, 7 figure
Arbutin encapsulated micelles improved transdermal delivery and suppression of cellular melanin production
Background: Hyperpigmentation is a skin disorder characterized by elevated production of melanin. Current treatment approaches mainly rely on the application of skin lightening chemicals, most of which have safety issues. Efficacy of delivery of the active ingredients to the target organ has also been a challenge. Transdermal based drug delivery platform has been shown to improve drug bioavailability, avoiding the hepatic first pass metabolism, decrease gastrointestinal side effects, and eventually enhance patient compliance. Results: This article explores the utilization of micellar transdermal delivery technology to improve skin penetration and efficacy of arbutin, a hyperpigmentation agent. The suppression efficacy of cellular melanin production versus cell viability of four active ingredients commonly used in skin lightening products, namely allantoin, arbutin, glycolic acid, and hyaluronic acid were first compared. Arbutin was selected for the micellar delivery studies base on its comparatively low cytotoxicity and better performance in reducing melanin production. Micellar Arbutin cream was formulated using Urah® proprietary micellar technology and was assessed for its cellular melanin suppression efficacy and skin penetration capacity. Conclusion: The results show that micellar arbutin cream improved both the delivery and cellular melanin suppression, suggesting that micellar transdermal delivery may have potential application in addressing hyperpigmentation skin disorders.Published versio