Open Charm and Beauty at Ultrarelativistic Heavy Ion Colliders

Important goals of RHIC and LHC experiments with ion beams include the creation and study of new forms of matter, such as the Quark Gluon Plasma. Heavy quark production and attenuation will provide unique tomographic probes of that matter. We predict the suppression pattern of open charm and beauty in $Au+Au$ collisions at RHIC and LHC energies based on the DGLV formalism of radiative energy loss. A cancelation between effects due to the $\sqrt{s}$ energy dependence of the high $p_T$ slope and heavy quark energy loss is predicted to lead to surprising similarity of heavy quark suppression at RHIC and LHC.Comment: 4 pages, 6 *.eps files combined into 4 figure

MicroRNA-Regulated Signaling Pathways: Potential Biomarkers for Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and invasive type of pancreatic cancer (PCa) and is expected to be the second most common cause of cancer-associated deaths. The high mortality rate is due to the asymptomatic progression of the clinical features until the advanced stages of the disease and the limited effectiveness of the current therapeutics. Aberrant expression of several microRNAs (miRs/miRNAs) has been related to PDAC progression and thus they could be potential early diagnostic, prognostic, and/or therapeutic predictors for PDAC. miRs are small (18 to 24 nucleotides long) non-coding RNAs, which regulate the expression of key genes by targeting their 3′-untranslated mRNA region. Increased evidence has also suggested that the chemoresistance of PDAC cells is associated with metabolic alterations. Metabolic stress and the dysfunctionality of systems to compensate for the altered metabolic status of PDAC cells is the foundation for cellular damage. Current data have implicated multiple systems as hallmarks of PDAC development, such as glutamine redox imbalance, oxidative stress, and mitochondrial dysfunction. Hence, both the aberrant expression of miRs and dysregulation in metabolism can have unfavorable effects in several biological processes, such as apoptosis, cell proliferation, growth, survival, stress response, angiogenesis, chemoresistance, invasion, and migration. Therefore, due to these dismal statistics, it is crucial to develop beneficial therapeutic strategies based on an improved understanding of the biology of both miRs and metabolic mediators. This review focuses on miR-mediated pathways and therapeutic resistance mechanisms in PDAC and evaluates the impact of metabolic alterations in the progression of PDAC

Genomic analysis of multidrug-resistant Escherichia coli ST58 causing urosepsis

© 2018 Sequence type 58 (ST58) phylogroup B1 Escherichia coli have been isolated from a wide variety of mammalian and avian hosts but are not noted for their ability to cause serious disease in humans or animals. Here we determined the genome sequences of two multidrug-resistant E. coli ST58 strains from urine and blood of one patient using a combination of Illumina and Single Molecule, Real-Time (SMRT) sequencing. Both ST58 strains were clonal and were characterised as serotype O8:H25, phylogroup B1 and carried a complex resistance locus/loci (CRL) that featured an atypical class 1 integron with a dfrA5 (trimethoprim resistance) gene cassette followed by only 24 bp of the 3ʹ-CS. CRL that carry this particular integron have been described previously in E. coli from cattle, pigs and humans in Australia. The integron abuts a copy of Tn6029, an IS26-flanked composite transposon encoding blaTEM, sul2 and strAB genes that confer resistance to ampicillin, sulfathiazole and streptomycin, respectively. The CRL resides within a novel Tn2610-like hybrid Tn1721/Tn21 transposon on an IncF, ColV plasmid (pSDJ2009-52F) of 138 553 bp that encodes virulence associated genes implicated in life-threatening extraintestinal pathogenic E. coli (ExPEC) infections. Notably, pSDJ2009-52F shares high sequence identity with pSF-088-1, a plasmid reported in an E. coli ST95 strain from a patient with blood sepsis from a hospital in San Francisco. These data suggest that extraintestinal infections caused by E. coli carrying ColV-like plasmids, irrespective of their phylogroup or ST, may pose a potential threat to human health, particularly to the elderly and immunocompromised

Magnetic and electric contributions to the energy loss in a dynamical QCD medium

The computation of radiative energy loss in a finite size QCD medium with dynamical constituents is a key ingredient for obtaining reliable predictions for jet quenching in ultra-relativistic heavy ion collisions. It was previously shown that energy loss in dynamical QCD medium is significantly higher compared to static QCD medium. To understand this difference, we here analyze magnetic and electric contributions to energy loss in dynamical QCD medium. We find that the significantly higher energy loss in the dynamical case is entirely due to appearance of magnetic contribution in the dynamical medium. While for asymptotically high energies, the energy loss in static and dynamical medium approach the same value, we find that the physical origin of the energy loss in these two cases is different.Comment: 6 pages, 4 figure

Transition of collective land in modernistic residential settings in New Belgrade, Serbia

Turbulent periods of transition from socialism to neoliberal capitalism, which have a ected the relationships between holders of power and governing structures in Serbia, have left a lasting impact on the urban spaces of Belgrade’s cityscape. The typical assumption is that the transformation of the urban form in the post-socialist transition is induced by planning interventions which serve to legitimize these neoliberal aspirations. The methodological approach of this paper is broadly structured as a chronological case analysis at three levels: the identification of three basic periods of institutional change, historical analysis of the urban policies that permitted transformation of the subject area, and morphogenesis of the selected site alongside the Sava River in New Belgrade. Neoliberal aspirations are traced through the moments of destruction and moments of creation as locally specific manifestations of neoliberal mechanisms observable through the urban form. Comparison of all three levels of the study traces how planning and political decisions have a ected strategic directions of development and, consequently, the dynamics and spatial logic of how new structures have invaded the street frontage. The paper demonstrates that planning interventions in the post-socialist transition period, guided by the neoliberal mechanisms, has had a profound impact on the super-block morphology

Role of microRNAs in response to cadmium chloride in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal and aggressive malignancies with a 5-year survival rate less than 9%. Early detection is particularly difficult due to the lack of symptoms even in advanced stages. microRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are involved in the pathogenesis of several malignancies including PDAC. Alterations of miR expressions can lead to apoptosis, angiogenesis, and metastasis. The role of environmental pollutants such as cadmium (Cd) in PDAC has been suggested but not fully understood. This study underlines the role of miRs (miR-221, miR-155, miR-126) in response to cadmium chloride (CdCl2) in vitro. Lethal concentration (LC50) values for CdCl2 resulted in a toxicity series of AsPC-1>HPNE>BxPC3>Panc-1=Panc-10.5. Following the treatment with CdCl2, miR-221 and miR-155 were significantly overexpressed, whereas miR-126 was downregulated. An increase in epithelial–mesenchymal transition (EMT) via the dysregulation of mesenchymal markers such as Wnt-11,E-cadherin, Snail, and Zeb1 was also observed. Hence, this study has provided evidence to suggest that the environmental pollutant Cd can have a signifcant role in the development of PDAC, suggesting a signifcant correlation between miRs and Cd exposure during PDAC progression. Further studies are needed to investigate the precise role of miRs in PDAC progression as well as the role of Cd and other environmental pollutants

A hybrid metal/semiconductor electron pump for quantum metrology

Electron pumps capable of delivering a current higher than 100pA with sufficient accuracy are likely to become the direct mise en pratique of the possible new quantum definition of the ampere. Furthermore, they are essential for closing the quantum metrological triangle experiment which tests for possible corrections to the quantum relations linking e and h, the electron charge and the Planck constant, to voltage, resistance and current. We present here single-island hybrid metal/semiconductor transistor pumps which combine the simplicity and efficiency of Coulomb blockade in metals with the unsurpassed performances of silicon switches. Robust and simple pumping at 650MHz and 0.5K is demonstrated. The pumped current obtained over a voltage bias range of 1.4mV corresponds to a relative deviation of 5e-4 from the calculated value, well within the 1.5e-3 uncertainty of the measurement setup. Multi-charge pumping can be performed. The simple design fully integrated in an industrial CMOS process makes it an ideal candidate for national measurement institutes to realize and share a future quantum ampere

Paleolinguistics brings more light on the earliest history of the traditional Eurasian pulse crops

Traditional pulse crops such as pea, lentil, field bean, bitter vetch, chickpea and common vetch originate from Middle East, Mediterranean and Central Asia^1^. They were a part of human diets in hunter-gatherers communities^2^ and are one of the most ancient cultivated crops^3,4^. Europe has always been rich in languages^5^, with individual families still preserving common vocabularies related to agriculture^6,7^. The evidence on the early pulse history witnessed by the attested roots in diverse Eurasian proto-languages remains insufficiently clarified and its potential for supporting archaeobotanical findings is still non-assessed. Here we show that the paleolinguistic research may contribute to archaeobotany in understanding the role traditional Eurasian pulse crops had in the everyday life of ancient Europeans. It was found that the Proto-Indo-European language^8,9^ had the largest number of roots directly related to pulses, such as *arnk(')- (a leguminous plant), *bhabh- (field bean), *erəgw[h]- (a kernel of leguminous plant; pea), *ghArs- (a leguminous plant), *kek-, *k'ik'- (pea) and *lent- (lentil)^10,11,12^, numerous words subsequently related to pulses^13,14^ and borrowings from one branch to another^15^, confirming their essential place in the nutrition of Proto-Indo-Europeans^16,17,18^. It was also determined that pea was the most important among Proto-Uralic people^19,20,21^, while pea and lentil were the most significant in the agriculture of Proto-Altaic people^22,23,24^. Pea and bean were most common among Caucasians^25,26^, Basques^27,28^ and their hypothetical common forefathers^29^ and bean and lentil among the Afro-Asiatic ancestors of modern Maltese^30^. Our results demonstrate that pulses were common among the ancestors of present European nations and that paleolinguistics and its lexicological and etymological analysis may be useful in better understanding the earliest days of traditional Eurasian crops. We believe our results could be a basis for advanced multidisciplinary approach to the pulse crop domestication, involving plant scientists, archaeobotanists and linguists, and for reconstructing even earlier periods of pulse history