Demographic characteristics of HIV positive and HIV negative studied subjects

1<p>Age median (IR, interquantile range) in years.</p>2<p>Of these, n = 2 individuals were occupationally exposed to HIV; risk group is unknown for n = 14 individuals.</p

Kaplan Meier Analysis of 506 seroconverters showing a relation of CCR5Δ32 genotype with a CD4⁺ T-cell count <200 µl⁻¹.

<p>A CD4⁺ T-cell count <200 µl-1 was documented for n = 57 of 422 individuals homozygous for the wildtype CCR5 genotype, and for n = 9 out of 84 CCR5Δ32 heterozygotes. Data censoring was due to introduction of antiretroviral therapy before a CD4 cell count of 200 µl⁻¹ was reached. The difference between both groups implied by the Kaplan-Meier diagram is reflected in a statistical trend (p = 0.1 as calculated by the Log-Rank test).</p

Relation of CCR5Δ32 genotype with viral setpoints in 319 Caucasian seroconverters.

<p>Scattered dots represent individual viral setpoints (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002747#s4" target="_blank">Material and Methods</a> for a definition), whereas vertical lines demarcate the median in each genetic group.</p

Clinical, immunological and viral load characteristics in an HIV-infected patient homozygous for the CCR5Δ32 deletion (patient#12).

<p>Antiretroviral therapy was initiated twice, eight days after diagnosis with efavirenz (EFV), stavudine (d4T) and lopinavir-ritonavir (LPVr) and again, following rapid disease progression, 18 months after diagnosis with Efavirenz and Zidovudine (AZT) plus Lamivudine (3TC). Unbroken line with closed circles: CD4⁺ T-cell counts. Unbroken line with closed diamonds: Plasma viral loads. Broken line with closed circles: CD8⁺ T-cell counts. Blue arrow: negative HIV-1 antibody test. Red arrow: positive HIV-1 antibody test. Black arrows: Proctitis (1) / Shigellosis (2).</p

CCR5Δ32 genotype distribution in HIV-positive and HIV-negative study subjects

1<p>2×2 or 3×2 χ2 comparisons, depending on the presence or absence of heterozygous and mutant homozygotes in the respective subgroup. Comparisons were conducted separately according to ethnicity</p